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Neurofibroma of the palate.

Bharath TS, Krishna YR, Nalabolu GR, Pasupuleti S, Surapaneni S, Ganta SB - Case Rep Dent (2014)

Bottom Line: There are two distinct variants of neurofibromatosis type I and type II.We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I.The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh 534 202, India.

ABSTRACT
Neurofibroma is a benign peripheral nerve sheath tumor comprising variable mixture of Schwann cells, perineurial-like cells, and fibroblasts. Neurofibroma may occur as solitary lesion or as part of a generalised syndrome of neurofibromatosis or very rarely as multiple neurofibromas without any associated syndrome. There are two distinct variants of neurofibromatosis type I and type II. We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I. The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry. Literature was reviewed and different types of neurofibroma, their incidence and frequency in the oral cavity, its association with neurofibromatosis, clinical manifestations, histopathologic characteristics, immunohistochemical analysis, behaviour, treatment, and recurrence are discussed.

No MeSH data available.


Related in: MedlinePlus

S-100 immunopositivity.
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fig5: S-100 immunopositivity.

Mentions: The lesional tissue section showed positive immunoreactivity to S-100 (Figure 5), neuron-specific enolase, and vimentin and negative immunoreactivity to desmin and pancytokeratin. Based on both histopathological and immunohistochemical analysis the final diagnosis was consistent with the clinical diagnosis of neurofibroma of the palate associated with neurofibromatosis type I. Patient was kept under observation for periodical review and there was no recurrence on examination after 3 months.


Neurofibroma of the palate.

Bharath TS, Krishna YR, Nalabolu GR, Pasupuleti S, Surapaneni S, Ganta SB - Case Rep Dent (2014)

S-100 immunopositivity.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016852&req=5

fig5: S-100 immunopositivity.
Mentions: The lesional tissue section showed positive immunoreactivity to S-100 (Figure 5), neuron-specific enolase, and vimentin and negative immunoreactivity to desmin and pancytokeratin. Based on both histopathological and immunohistochemical analysis the final diagnosis was consistent with the clinical diagnosis of neurofibroma of the palate associated with neurofibromatosis type I. Patient was kept under observation for periodical review and there was no recurrence on examination after 3 months.

Bottom Line: There are two distinct variants of neurofibromatosis type I and type II.We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I.The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh 534 202, India.

ABSTRACT
Neurofibroma is a benign peripheral nerve sheath tumor comprising variable mixture of Schwann cells, perineurial-like cells, and fibroblasts. Neurofibroma may occur as solitary lesion or as part of a generalised syndrome of neurofibromatosis or very rarely as multiple neurofibromas without any associated syndrome. There are two distinct variants of neurofibromatosis type I and type II. We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I. The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry. Literature was reviewed and different types of neurofibroma, their incidence and frequency in the oral cavity, its association with neurofibromatosis, clinical manifestations, histopathologic characteristics, immunohistochemical analysis, behaviour, treatment, and recurrence are discussed.

No MeSH data available.


Related in: MedlinePlus