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Neurofibroma of the palate.

Bharath TS, Krishna YR, Nalabolu GR, Pasupuleti S, Surapaneni S, Ganta SB - Case Rep Dent (2014)

Bottom Line: There are two distinct variants of neurofibromatosis type I and type II.We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I.The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh 534 202, India.

ABSTRACT
Neurofibroma is a benign peripheral nerve sheath tumor comprising variable mixture of Schwann cells, perineurial-like cells, and fibroblasts. Neurofibroma may occur as solitary lesion or as part of a generalised syndrome of neurofibromatosis or very rarely as multiple neurofibromas without any associated syndrome. There are two distinct variants of neurofibromatosis type I and type II. We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I. The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry. Literature was reviewed and different types of neurofibroma, their incidence and frequency in the oral cavity, its association with neurofibromatosis, clinical manifestations, histopathologic characteristics, immunohistochemical analysis, behaviour, treatment, and recurrence are discussed.

No MeSH data available.


Related in: MedlinePlus

Peripheral nerve tissue within the perineural sheath and dilated blood capillaries.
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fig4: Peripheral nerve tissue within the perineural sheath and dilated blood capillaries.

Mentions: Hematoxylin and eosin stained soft tissue section showed a benign neoplasm of the fibrous connective tissue exhibiting partial encapsulation. The connective tissue is highly cellular, interspersed with areas of nerve bundles. The cells are elongated spindle shaped with wavy and bent nuclei (Figure 3). They are separated by fine and wavy collagen fibers. Myxomatous areas are also seen. Peripheral nerve tissues within the perineural sheath are evident within the fibrous connective tissue (Figure 4). Few mast cells, dilated blood vessels, entrapped adipocytes, and mucous acini are evident all over the lesional area.


Neurofibroma of the palate.

Bharath TS, Krishna YR, Nalabolu GR, Pasupuleti S, Surapaneni S, Ganta SB - Case Rep Dent (2014)

Peripheral nerve tissue within the perineural sheath and dilated blood capillaries.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016852&req=5

fig4: Peripheral nerve tissue within the perineural sheath and dilated blood capillaries.
Mentions: Hematoxylin and eosin stained soft tissue section showed a benign neoplasm of the fibrous connective tissue exhibiting partial encapsulation. The connective tissue is highly cellular, interspersed with areas of nerve bundles. The cells are elongated spindle shaped with wavy and bent nuclei (Figure 3). They are separated by fine and wavy collagen fibers. Myxomatous areas are also seen. Peripheral nerve tissues within the perineural sheath are evident within the fibrous connective tissue (Figure 4). Few mast cells, dilated blood vessels, entrapped adipocytes, and mucous acini are evident all over the lesional area.

Bottom Line: There are two distinct variants of neurofibromatosis type I and type II.We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I.The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Vishnu Dental College, Bhimavaram, Andhra Pradesh 534 202, India.

ABSTRACT
Neurofibroma is a benign peripheral nerve sheath tumor comprising variable mixture of Schwann cells, perineurial-like cells, and fibroblasts. Neurofibroma may occur as solitary lesion or as part of a generalised syndrome of neurofibromatosis or very rarely as multiple neurofibromas without any associated syndrome. There are two distinct variants of neurofibromatosis type I and type II. We present a case of neurofibroma of the hard palate associated with neurofibromatosis type I. The diagnosis of the lesion was made based on the clinical findings, family history, histopathology, and immunohistochemistry. Literature was reviewed and different types of neurofibroma, their incidence and frequency in the oral cavity, its association with neurofibromatosis, clinical manifestations, histopathologic characteristics, immunohistochemical analysis, behaviour, treatment, and recurrence are discussed.

No MeSH data available.


Related in: MedlinePlus