A conserved sequence in calmodulin regulated spectrin-associated protein 1 links its interaction with spectrin and calmodulin to neurite outgrowth.
Bottom Line: Calmodulin regulated spectrin-associated protein 1 (CAMSAP1) is a vertebrate microtubule-binding protein, and a representative of a family of cytoskeletal proteins that arose with animals.Biol.We conclude that CC1 represents a functional region of CAMSAP1, which links spectrin-binding to neurite outgrowth.
Affiliation: Department of Biosciences, University of Kent, Kent, UK.Show MeSH
Related in: MedlinePlus
Mentions: Figure 2a, summarizes the structure of αII/βII-spectrin tetramers: note that there are two C-terminal splice variants of βII-spectrin. A long C-terminal variant (βIIΣ1) contains a pleckstrin homology domain joined to the last of the helical repeats (the partial repeat 17) via a linker region. A short splice (βIIΣ2) variant arises from differential mRNA splicing that eliminates the PH domain and part of the linker region.
Affiliation: Department of Biosciences, University of Kent, Kent, UK.