Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.
Bottom Line: The three SK channel subunits display different developmental expression gradients in distinct CNS regions, with time points of expression and up- or downregulation that can be associated with a range of diverse developmental events.Their early expression in embryonic development suggests an involvement of SK channels in the regulation of developmental processes.Additionally, this study shows how the postnatal ontogenetic patterns lead to the adult expression map for each SK channel subunit and how their coexpression in the same regions or neurons varies throughout development.
Affiliation: Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075, Göttingen, Germany.Show MeSH
Mentions: In the cranial sensory ganglia, strong signals for SK1 and SK2 (Tables1, 2), but not for SK3 (Table3), were observed at E19 (Fig. 13A–C) and E21 (Fig. 13J,K left) in the inferior ganglion of the glossopharyngeal nerve, innervating the pharynx, tonsils, tongue, middle ear, auditory tube, and ear canal. In the trigeminal ganglion, all three SK subunits were observed at E15 (Fig. 12J–L) and E17 (Fig. 2M–O, Tables3). SK1 displayed strong expression (Fig. 2J,M). At E19 and E21, SK1 expression persists (Fig. 13A, Table1) and SK2 levels increase (Fig. 13B, Table2), but SK3 shows a pronounced decline in expression (Fig. 3C, Table1).
Affiliation: Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075, Göttingen, Germany.