Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.
Bottom Line: The three SK channel subunits display different developmental expression gradients in distinct CNS regions, with time points of expression and up- or downregulation that can be associated with a range of diverse developmental events.Their early expression in embryonic development suggests an involvement of SK channels in the regulation of developmental processes.Additionally, this study shows how the postnatal ontogenetic patterns lead to the adult expression map for each SK channel subunit and how their coexpression in the same regions or neurons varies throughout development.
Affiliation: Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075, Göttingen, Germany.Show MeSH
Mentions: To analyze the distribution patterns of SK transcripts after birth, we extended our in situ hybridization analysis and mapped the distributions of SK1, SK2, and SK3 mRNAs in the rat postnatal nervous system between P1 and P24 by examination of X-ray film images (Figs. 7) and emulsion-coated sections (Figs. 10, 12, 14, 15). The results of the evaluation at the cellular level are summarized in Tables6.
Affiliation: Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075, Göttingen, Germany.