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Neuronal damage of the dorsal hippocampus induced by long-term right common carotid artery occlusion in rats.

Thong-Asa W, Tilokskulchai K - Iran J Basic Med Sci (2014)

Bottom Line: Pathological changes were observed in three regions (CA1, CA3 and DG) of the dorsal hippocampus.Significant increase of damaged neurons in CA1 region at 8, 16, 48, and 56 weeks were observed, whereas in CA3 and DG regions it was at 16, 48, and 56 weeks.Gradual increase of damaged neurons was found without significant change in hemodynamic parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Faculty of Science, ASESRU, Kasetsart University, 10900, Bangkok, Thailand.

ABSTRACT

Objective(s): The present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (UCO) on the dorsal hippocampal neurons in rats.

Materials and methods: Sixty four male Sprague-Dawley rats aged 4 months were divided into two groups of sham and UCO. These two groups were further divided into 4 sets of histopathological observation periods at 8, 16, 48 and 56 weeks after arterial occlusion. Pathological changes were observed in three regions (CA1, CA3 and DG) of the dorsal hippocampus.

Results: Significant increase of damaged neurons in CA1 region at 8, 16, 48, and 56 weeks were observed, whereas in CA3 and DG regions it was at 16, 48, and 56 weeks. Gradual increase of damaged neurons was found without significant change in hemodynamic parameters.

Conclusion: Long-term right common carotid artery occlusion in rats induced delay and progressive damage to the dorsal hippocampus with regional vulnerability from CA1 followed by CA3 and DG regions.

No MeSH data available.


Related in: MedlinePlus

Change in systolic blood pressure (SBP) after right common carotid artery occlusion in rats. SBP was measured in awake and restrained rats using tail cuff method. Abbreviations: Sham: sham-operated control; UCO: unilateral (right) common carotid artery occlusion; hrs: hr; *: P-value < 0.05 compared to baseline value
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Figure 1: Change in systolic blood pressure (SBP) after right common carotid artery occlusion in rats. SBP was measured in awake and restrained rats using tail cuff method. Abbreviations: Sham: sham-operated control; UCO: unilateral (right) common carotid artery occlusion; hrs: hr; *: P-value < 0.05 compared to baseline value

Mentions: Physiological parameters such as SBP, DBP, MAP, and HR were compared to the baseline value and significant falling was found only 3 – 8 hr after permanent right common carotid artery occlusion (within group). Twenty-four hr later, all physiological parameters returned to normal with no significant differences when compared to baseline value both within and between groups (Table 1 and Figure 1).


Neuronal damage of the dorsal hippocampus induced by long-term right common carotid artery occlusion in rats.

Thong-Asa W, Tilokskulchai K - Iran J Basic Med Sci (2014)

Change in systolic blood pressure (SBP) after right common carotid artery occlusion in rats. SBP was measured in awake and restrained rats using tail cuff method. Abbreviations: Sham: sham-operated control; UCO: unilateral (right) common carotid artery occlusion; hrs: hr; *: P-value < 0.05 compared to baseline value
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016694&req=5

Figure 1: Change in systolic blood pressure (SBP) after right common carotid artery occlusion in rats. SBP was measured in awake and restrained rats using tail cuff method. Abbreviations: Sham: sham-operated control; UCO: unilateral (right) common carotid artery occlusion; hrs: hr; *: P-value < 0.05 compared to baseline value
Mentions: Physiological parameters such as SBP, DBP, MAP, and HR were compared to the baseline value and significant falling was found only 3 – 8 hr after permanent right common carotid artery occlusion (within group). Twenty-four hr later, all physiological parameters returned to normal with no significant differences when compared to baseline value both within and between groups (Table 1 and Figure 1).

Bottom Line: Pathological changes were observed in three regions (CA1, CA3 and DG) of the dorsal hippocampus.Significant increase of damaged neurons in CA1 region at 8, 16, 48, and 56 weeks were observed, whereas in CA3 and DG regions it was at 16, 48, and 56 weeks.Gradual increase of damaged neurons was found without significant change in hemodynamic parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Faculty of Science, ASESRU, Kasetsart University, 10900, Bangkok, Thailand.

ABSTRACT

Objective(s): The present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (UCO) on the dorsal hippocampal neurons in rats.

Materials and methods: Sixty four male Sprague-Dawley rats aged 4 months were divided into two groups of sham and UCO. These two groups were further divided into 4 sets of histopathological observation periods at 8, 16, 48 and 56 weeks after arterial occlusion. Pathological changes were observed in three regions (CA1, CA3 and DG) of the dorsal hippocampus.

Results: Significant increase of damaged neurons in CA1 region at 8, 16, 48, and 56 weeks were observed, whereas in CA3 and DG regions it was at 16, 48, and 56 weeks. Gradual increase of damaged neurons was found without significant change in hemodynamic parameters.

Conclusion: Long-term right common carotid artery occlusion in rats induced delay and progressive damage to the dorsal hippocampus with regional vulnerability from CA1 followed by CA3 and DG regions.

No MeSH data available.


Related in: MedlinePlus