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The impact of depression and ghrelin on body weight in migraineurs.

Turan B, Siva ZO, Uluduz D, Konukoglu D, Erenler F, Saip S, Goksan B, Siva A - J Headache Pain (2014)

Bottom Line: Comorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity.Participants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers.Body mass index (BMI) was calculated by measuring height and weight.

View Article: PubMed Central - HTML - PubMed

Affiliation: Neurology Department, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey. deryaulu@yahoo.com.

ABSTRACT

Background: Comorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity. We examined the moderating and mediating roles of ghrelin in the relationship between depression (and anxiety) and body weight in newly diagnosed migraineurs.

Methods: Participants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers. Body mass index (BMI) was calculated by measuring height and weight. Ghrelin was assessed at fasting. Depression was assessed with the Hamilton Depression scale, and anxiety with the Hamilton Anxiety scale.

Results: The data did not support the mediating role of ghrelin in the relationship between depression (or anxiety) and BMI for either the migraine or the control group. The interaction between ghrelin and depression as well as anxiety was significant for the migraine group, but not for the control group. Depressed (or anxious) migraineurs had a positive association between ghrelin and BMI, whereas for the non-depressed (or non-anxious) migraineurs this association was negative.

Conclusions: Depression and anxiety moderated the effect of ghrelin on BMI for migraineurs. Management of anxiety and depression might be regarded as part of migraine treatment.

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Anxiety status moderates the effect of ghrelin on BMI.
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Figure 2: Anxiety status moderates the effect of ghrelin on BMI.

Mentions: Similar analyses using anxiety instead of depression yielded parallel results (Figure 2). The interaction between anxiety status and baseline ghrelin was significant for the migraine group (B = .04, t = 2.59, p = .01), but not for the control group, (B = .00 t = -.05, p = .96). Follow-up simple slope analyses for the migraine group revealed that for migraineurs with anxiety ghrelin had a positive association with BMI (B = .02, t = 1.83, p = .07), whereas for migraineurs without anxiety the association between ghrelin and BMI was negative (B = -.02, t = -1.86, p = .07).


The impact of depression and ghrelin on body weight in migraineurs.

Turan B, Siva ZO, Uluduz D, Konukoglu D, Erenler F, Saip S, Goksan B, Siva A - J Headache Pain (2014)

Anxiety status moderates the effect of ghrelin on BMI.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016645&req=5

Figure 2: Anxiety status moderates the effect of ghrelin on BMI.
Mentions: Similar analyses using anxiety instead of depression yielded parallel results (Figure 2). The interaction between anxiety status and baseline ghrelin was significant for the migraine group (B = .04, t = 2.59, p = .01), but not for the control group, (B = .00 t = -.05, p = .96). Follow-up simple slope analyses for the migraine group revealed that for migraineurs with anxiety ghrelin had a positive association with BMI (B = .02, t = 1.83, p = .07), whereas for migraineurs without anxiety the association between ghrelin and BMI was negative (B = -.02, t = -1.86, p = .07).

Bottom Line: Comorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity.Participants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers.Body mass index (BMI) was calculated by measuring height and weight.

View Article: PubMed Central - HTML - PubMed

Affiliation: Neurology Department, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey. deryaulu@yahoo.com.

ABSTRACT

Background: Comorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity. We examined the moderating and mediating roles of ghrelin in the relationship between depression (and anxiety) and body weight in newly diagnosed migraineurs.

Methods: Participants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers. Body mass index (BMI) was calculated by measuring height and weight. Ghrelin was assessed at fasting. Depression was assessed with the Hamilton Depression scale, and anxiety with the Hamilton Anxiety scale.

Results: The data did not support the mediating role of ghrelin in the relationship between depression (or anxiety) and BMI for either the migraine or the control group. The interaction between ghrelin and depression as well as anxiety was significant for the migraine group, but not for the control group. Depressed (or anxious) migraineurs had a positive association between ghrelin and BMI, whereas for the non-depressed (or non-anxious) migraineurs this association was negative.

Conclusions: Depression and anxiety moderated the effect of ghrelin on BMI for migraineurs. Management of anxiety and depression might be regarded as part of migraine treatment.

Show MeSH
Related in: MedlinePlus