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Sputum myeloperoxidase in chronic obstructive pulmonary disease.

Zhu A, Ge D, Zhang J, Teng Y, Yuan C, Huang M, Adcock IM, Barnes PJ, Yao X - Eur. J. Med. Res. (2014)

Bottom Line: Sputum myeloperoxidase (MPO) is recognized as a marker of neutrophil activity.A total of 24 studies were included in the meta-analysis.Theophylline treatment was able to reduce MPO levels in COPD patients, while glucocorticoid treatment failed to achieve the same result.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. xyao1998@126.com.

ABSTRACT

Background: Airway inflammation, especially neutrophilic airway inflammation, is a cardinal pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients. The ideal biomarkers characterizing the inflammation might have important potential clinical applications in disease assessment and therapeutic intervention. Sputum myeloperoxidase (MPO) is recognized as a marker of neutrophil activity. The purpose of this meta-analysis is to determine whether sputum MPO levels could reflect disease status or be regulated by regular medications for COPD.

Methods: Studies were identified by searching PubMed, Embase, the Cochrane Database, CINAHL and http://www.controlled-trials.com for relevant reports published before September 2012. Observational studies comparing sputum MPO in COPD patients and healthy subjects or asthmatics, or within the COPD group, and studies comparing sputum MPO before and after treatment were all included. Data were independently extracted by two investigators and analyzed using STATA 10.0 software.

Results: A total of 24 studies were included in the meta-analysis. Sputum MPO levels were increased in stable COPD patients when compared with normal controls, and this increase was especially pronounced during exacerbations as compared with MPO levels during the stable state. Theophylline treatment was able to reduce MPO levels in COPD patients, while glucocorticoid treatment failed to achieve the same result.

Conclusion: Sputum MPO might be a promising biomarker for guiding COPD management; however, further investigations are needed to confirm this.

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Related in: MedlinePlus

Results of the systematic literature search.
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Figure 1: Results of the systematic literature search.

Mentions: In the primary literature search, 405 records were identified, of which 262 were unique. After screening the titles and abstracts, 219 studies were excluded because they were either animal studies, review articles, or irrelevant to the current analysis, yielding 43 candidate studies. Of the 43 reports selected for detailed evaluation, 19 studies were further excluded for various reasons (FigureĀ 1). Finally, 24 articles were included in our meta-analysis.


Sputum myeloperoxidase in chronic obstructive pulmonary disease.

Zhu A, Ge D, Zhang J, Teng Y, Yuan C, Huang M, Adcock IM, Barnes PJ, Yao X - Eur. J. Med. Res. (2014)

Results of the systematic literature search.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016613&req=5

Figure 1: Results of the systematic literature search.
Mentions: In the primary literature search, 405 records were identified, of which 262 were unique. After screening the titles and abstracts, 219 studies were excluded because they were either animal studies, review articles, or irrelevant to the current analysis, yielding 43 candidate studies. Of the 43 reports selected for detailed evaluation, 19 studies were further excluded for various reasons (FigureĀ 1). Finally, 24 articles were included in our meta-analysis.

Bottom Line: Sputum myeloperoxidase (MPO) is recognized as a marker of neutrophil activity.A total of 24 studies were included in the meta-analysis.Theophylline treatment was able to reduce MPO levels in COPD patients, while glucocorticoid treatment failed to achieve the same result.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. xyao1998@126.com.

ABSTRACT

Background: Airway inflammation, especially neutrophilic airway inflammation, is a cardinal pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients. The ideal biomarkers characterizing the inflammation might have important potential clinical applications in disease assessment and therapeutic intervention. Sputum myeloperoxidase (MPO) is recognized as a marker of neutrophil activity. The purpose of this meta-analysis is to determine whether sputum MPO levels could reflect disease status or be regulated by regular medications for COPD.

Methods: Studies were identified by searching PubMed, Embase, the Cochrane Database, CINAHL and http://www.controlled-trials.com for relevant reports published before September 2012. Observational studies comparing sputum MPO in COPD patients and healthy subjects or asthmatics, or within the COPD group, and studies comparing sputum MPO before and after treatment were all included. Data were independently extracted by two investigators and analyzed using STATA 10.0 software.

Results: A total of 24 studies were included in the meta-analysis. Sputum MPO levels were increased in stable COPD patients when compared with normal controls, and this increase was especially pronounced during exacerbations as compared with MPO levels during the stable state. Theophylline treatment was able to reduce MPO levels in COPD patients, while glucocorticoid treatment failed to achieve the same result.

Conclusion: Sputum MPO might be a promising biomarker for guiding COPD management; however, further investigations are needed to confirm this.

Show MeSH
Related in: MedlinePlus