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Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma.

Su ZX, Zhao J, Rong ZH, Geng WM, Wu YG, Qin CK - Diagn Pathol (2014)

Bottom Line: The expression of miR-25 was significantly upregulated in HCC tissues when compared with adjacent normal tissues (p<0.0001).The multivariate Cox regression analysis indicated that miR-25 expression (HR=2.179; p=0.001), TNM stage (HR=1.782; p=0.014), and vein invasion (HR=1.624; p=0.020) were independent prognostic factors for overall survival.Our data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Hepatobiliary Surgery, ShanDong Provincial Hospital affiliated to ShanDong University, 324 JingWu Road, Jinan, ShanDong Province 250021, China. dr_suzhongxue@126.com.

ABSTRACT

Background: Accumulating evidence has shown that up-regulation of microRNA-25(miR-25) is associated with the prognosis of several types of human malignant solid tumors. However, whether miR-25 expression has influence on the prognosis of hepatocellular carcinoma (HCC) is still unknown.

Methods: The differentially expressed amount of the miR-25 was validated in triplicate by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Survival rate was analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier. Multivariate analysis of the prognostic factors was performed with Cox regression model.

Results: The expression of miR-25 was significantly upregulated in HCC tissues when compared with adjacent normal tissues (p<0.0001). Patients who had high miR-25 expression had a shorter overall survival than patients who had low miR-25 expression (median overall survival, 31.0 months versus 42.9 months, p=0.0192). The multivariate Cox regression analysis indicated that miR-25 expression (HR=2.179; p=0.001), TNM stage (HR=1.782; p=0.014), and vein invasion (HR=1.624; p=0.020) were independent prognostic factors for overall survival.

Conclusion: Our data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis.

Virtual slide: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1989618421114309.

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Comparison of miR-25 expression levels between hepatocellular carcinoma tissues and adjacent normal tissues. Analysis using the two sample Student’ s t test showed that the relative expression levels of miR-25 in the hepatocellular carcinoma tissues were significantly higher than those in adjacent normal tissues (p<0.0001) SE, Standard Error.
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Figure 1: Comparison of miR-25 expression levels between hepatocellular carcinoma tissues and adjacent normal tissues. Analysis using the two sample Student’ s t test showed that the relative expression levels of miR-25 in the hepatocellular carcinoma tissues were significantly higher than those in adjacent normal tissues (p<0.0001) SE, Standard Error.

Mentions: The expression of miR-25 was significantly upregulated in HCC tissues (mean relative expression level: 8.287, SD=4.711) when compared with adjacent normal tissues(mean relative expression level: 4.177, SD=2.386, P<0.0001, Figure 1). The relationship between miR-25 expression level with clinicopathological variables of HCC patients was shown in Table 1. The relative miR-25 expression levels were significantly positively correlated with serum AFP (p=0.02) and TNM stage (p=0.01).


Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma.

Su ZX, Zhao J, Rong ZH, Geng WM, Wu YG, Qin CK - Diagn Pathol (2014)

Comparison of miR-25 expression levels between hepatocellular carcinoma tissues and adjacent normal tissues. Analysis using the two sample Student’ s t test showed that the relative expression levels of miR-25 in the hepatocellular carcinoma tissues were significantly higher than those in adjacent normal tissues (p<0.0001) SE, Standard Error.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4016611&req=5

Figure 1: Comparison of miR-25 expression levels between hepatocellular carcinoma tissues and adjacent normal tissues. Analysis using the two sample Student’ s t test showed that the relative expression levels of miR-25 in the hepatocellular carcinoma tissues were significantly higher than those in adjacent normal tissues (p<0.0001) SE, Standard Error.
Mentions: The expression of miR-25 was significantly upregulated in HCC tissues (mean relative expression level: 8.287, SD=4.711) when compared with adjacent normal tissues(mean relative expression level: 4.177, SD=2.386, P<0.0001, Figure 1). The relationship between miR-25 expression level with clinicopathological variables of HCC patients was shown in Table 1. The relative miR-25 expression levels were significantly positively correlated with serum AFP (p=0.02) and TNM stage (p=0.01).

Bottom Line: The expression of miR-25 was significantly upregulated in HCC tissues when compared with adjacent normal tissues (p<0.0001).The multivariate Cox regression analysis indicated that miR-25 expression (HR=2.179; p=0.001), TNM stage (HR=1.782; p=0.014), and vein invasion (HR=1.624; p=0.020) were independent prognostic factors for overall survival.Our data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Hepatobiliary Surgery, ShanDong Provincial Hospital affiliated to ShanDong University, 324 JingWu Road, Jinan, ShanDong Province 250021, China. dr_suzhongxue@126.com.

ABSTRACT

Background: Accumulating evidence has shown that up-regulation of microRNA-25(miR-25) is associated with the prognosis of several types of human malignant solid tumors. However, whether miR-25 expression has influence on the prognosis of hepatocellular carcinoma (HCC) is still unknown.

Methods: The differentially expressed amount of the miR-25 was validated in triplicate by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Survival rate was analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier. Multivariate analysis of the prognostic factors was performed with Cox regression model.

Results: The expression of miR-25 was significantly upregulated in HCC tissues when compared with adjacent normal tissues (p<0.0001). Patients who had high miR-25 expression had a shorter overall survival than patients who had low miR-25 expression (median overall survival, 31.0 months versus 42.9 months, p=0.0192). The multivariate Cox regression analysis indicated that miR-25 expression (HR=2.179; p=0.001), TNM stage (HR=1.782; p=0.014), and vein invasion (HR=1.624; p=0.020) were independent prognostic factors for overall survival.

Conclusion: Our data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis.

Virtual slide: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1989618421114309.

Show MeSH
Related in: MedlinePlus