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Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study.

Momma H, Niu K, Kobayashi Y, Huang C, Chujo M, Otomo A, Tadaura H, Miyata T, Nagatomi R - Diabetol Metab Syndr (2014)

Bottom Line: Serum soluble RAGE (sRAGE) were measured in 712 men and 176 women aged 30-83 years with serum C-reactive protein (hsCRP) concentration below 3 mg/L.Moreover, participants were categorized according to their median hsCRP and sRAGE values.Higher circulating RAGE concentrations were associated with lower prevalence of MetS and its components among Japanese men.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, 2-1 Seiryo-machi, Aoba-ku 980-8575 Sendai, Japan. nagatomi@med.tohoku.ac.jp.

ABSTRACT

Background: Although several studies showed that decreased soluble receptor for advanced glycation end products (sRAGE) is associated with metabolic syndrome (MetS), inflammation level has not been considered, even though ligand-RAGE interaction induces inflammation. The objective of the study was to determine the association between sRAGE and MetS among Japanese adult in a cross-sectional survey, taking the level of low grade inflammation into consideration.

Methods: Serum soluble RAGE (sRAGE) were measured in 712 men and 176 women aged 30-83 years with serum C-reactive protein (hsCRP) concentration below 3 mg/L. MetS was defined using the criteria of the American Heart Association Scientific Statements of 2009.

Results: After multivariable adjustment, among men, higher sRAGE levels were associated with lower odds of MetS as well as central obesity and elevated blood pressure. Comparing the extreme tertiles of sRAGE, odds ratios (95% confidence interval) were 0.58 (0.36-0.95; P for trend = 0.001) for MetS; 0.41 (0.25-0.52; P for trend < 0.001) for central obesity; and 0.45 (0.29-0.70; P for trend < 0.001) for elevated blood pressure. Moreover, participants were categorized according to their median hsCRP and sRAGE values. Men in the higher hsCRP/higher sRAGE category had a 40% lower odds ratio for MetS than those in the higher hsCRP/lower sRAGE category (P = 0.031). Among women, there was no association between sRAGE levels and the prevalence of MetS.

Conclusions: Higher circulating RAGE concentrations were associated with lower prevalence of MetS and its components among Japanese men.

No MeSH data available.


Related in: MedlinePlus

Relationship between serum sRAGE and esRAGE in men (A) and women (B). sRAGE, soluble receptor for advanced glycation end products. esRAGE, endogenous secretory RAGE. rs, Spearman rank-correlation coefficient.
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Figure 2: Relationship between serum sRAGE and esRAGE in men (A) and women (B). sRAGE, soluble receptor for advanced glycation end products. esRAGE, endogenous secretory RAGE. rs, Spearman rank-correlation coefficient.

Mentions: Of the 712 men, 179 (25.1%) had ≥3 MetS components. The median (interquartile range) values were 1259.0 (946.4–1609.1) pg/mL for serum sRAGE, 319.0 (235.7–432.2) pg/mL for serum esRAGE, and 0.38 (0.22–0.77) mg/L for hsCRP. Among women, 24 (13.6%) had ≥3 MetS components. The median (interquartile range) values were 1547.9 (1139.6–1922.0) pg/mL for serum sRAGE, 358.1 (259.3–461.5) pg/mL for serum esRAGE, and 0.23 (0.12–0.46) mg/L for hsCRP. The concentration of serum sRAGE was strongly correlated with the concentration of serum esRAGE (Figure 2).


Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study.

Momma H, Niu K, Kobayashi Y, Huang C, Chujo M, Otomo A, Tadaura H, Miyata T, Nagatomi R - Diabetol Metab Syndr (2014)

Relationship between serum sRAGE and esRAGE in men (A) and women (B). sRAGE, soluble receptor for advanced glycation end products. esRAGE, endogenous secretory RAGE. rs, Spearman rank-correlation coefficient.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016590&req=5

Figure 2: Relationship between serum sRAGE and esRAGE in men (A) and women (B). sRAGE, soluble receptor for advanced glycation end products. esRAGE, endogenous secretory RAGE. rs, Spearman rank-correlation coefficient.
Mentions: Of the 712 men, 179 (25.1%) had ≥3 MetS components. The median (interquartile range) values were 1259.0 (946.4–1609.1) pg/mL for serum sRAGE, 319.0 (235.7–432.2) pg/mL for serum esRAGE, and 0.38 (0.22–0.77) mg/L for hsCRP. Among women, 24 (13.6%) had ≥3 MetS components. The median (interquartile range) values were 1547.9 (1139.6–1922.0) pg/mL for serum sRAGE, 358.1 (259.3–461.5) pg/mL for serum esRAGE, and 0.23 (0.12–0.46) mg/L for hsCRP. The concentration of serum sRAGE was strongly correlated with the concentration of serum esRAGE (Figure 2).

Bottom Line: Serum soluble RAGE (sRAGE) were measured in 712 men and 176 women aged 30-83 years with serum C-reactive protein (hsCRP) concentration below 3 mg/L.Moreover, participants were categorized according to their median hsCRP and sRAGE values.Higher circulating RAGE concentrations were associated with lower prevalence of MetS and its components among Japanese men.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, 2-1 Seiryo-machi, Aoba-ku 980-8575 Sendai, Japan. nagatomi@med.tohoku.ac.jp.

ABSTRACT

Background: Although several studies showed that decreased soluble receptor for advanced glycation end products (sRAGE) is associated with metabolic syndrome (MetS), inflammation level has not been considered, even though ligand-RAGE interaction induces inflammation. The objective of the study was to determine the association between sRAGE and MetS among Japanese adult in a cross-sectional survey, taking the level of low grade inflammation into consideration.

Methods: Serum soluble RAGE (sRAGE) were measured in 712 men and 176 women aged 30-83 years with serum C-reactive protein (hsCRP) concentration below 3 mg/L. MetS was defined using the criteria of the American Heart Association Scientific Statements of 2009.

Results: After multivariable adjustment, among men, higher sRAGE levels were associated with lower odds of MetS as well as central obesity and elevated blood pressure. Comparing the extreme tertiles of sRAGE, odds ratios (95% confidence interval) were 0.58 (0.36-0.95; P for trend = 0.001) for MetS; 0.41 (0.25-0.52; P for trend < 0.001) for central obesity; and 0.45 (0.29-0.70; P for trend < 0.001) for elevated blood pressure. Moreover, participants were categorized according to their median hsCRP and sRAGE values. Men in the higher hsCRP/higher sRAGE category had a 40% lower odds ratio for MetS than those in the higher hsCRP/lower sRAGE category (P = 0.031). Among women, there was no association between sRAGE levels and the prevalence of MetS.

Conclusions: Higher circulating RAGE concentrations were associated with lower prevalence of MetS and its components among Japanese men.

No MeSH data available.


Related in: MedlinePlus