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A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

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Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

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Measles Incidence and antibody positive rate in Beijing, 1973–2007.
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Figure 7: Measles Incidence and antibody positive rate in Beijing, 1973–2007.

Mentions: From 1973 to 1977, antibody positive rate of measles increased from 73.3% to 95.8%, while incidence decreased from 248.7/100,000 to 42.2/100,000. Antibody positive rate of children 1–4 years was relative low, 63.8%-87.5%, when the first dose of MV was administrated at 6 months. Antibody positive rate of children 5–9 years was increased to 84.3%-97.4%, when the second and third dose of MV was administrated at 4 and 8 years old. From 1978 to 1996, antibody positive rate increased from the lowest 75.7% to higher 93.6%, while incidence declined from highest 146.0/100,000 in 1978 to lowest 0.3/100,000 in 1995. Age-specific antibody positive rate of 1–4 years was increased greatly from 68.0% to 97.9% while the first and second dose of MV was administrated at 8 months and 1.5 years old. Antibody positive rate increased from 70.6% to 98.0% for 5–14 years old , while students in Grade 1 and 7 was administrated MV from 1982. From 1997 to 2004, measles antibody positive rate fall to 93.4% and 73.4%, while incidence appeared slight rebound. During this period, age-specific antibody positive rate of 1–14 years was between 85.7% and 100%, except 68.6%-80.0% in 2003. Range of antibody positive rate in infants <1 years was 30.0%-61.2% (Figure 7).


A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Measles Incidence and antibody positive rate in Beijing, 1973–2007.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016557&req=5

Figure 7: Measles Incidence and antibody positive rate in Beijing, 1973–2007.
Mentions: From 1973 to 1977, antibody positive rate of measles increased from 73.3% to 95.8%, while incidence decreased from 248.7/100,000 to 42.2/100,000. Antibody positive rate of children 1–4 years was relative low, 63.8%-87.5%, when the first dose of MV was administrated at 6 months. Antibody positive rate of children 5–9 years was increased to 84.3%-97.4%, when the second and third dose of MV was administrated at 4 and 8 years old. From 1978 to 1996, antibody positive rate increased from the lowest 75.7% to higher 93.6%, while incidence declined from highest 146.0/100,000 in 1978 to lowest 0.3/100,000 in 1995. Age-specific antibody positive rate of 1–4 years was increased greatly from 68.0% to 97.9% while the first and second dose of MV was administrated at 8 months and 1.5 years old. Antibody positive rate increased from 70.6% to 98.0% for 5–14 years old , while students in Grade 1 and 7 was administrated MV from 1982. From 1997 to 2004, measles antibody positive rate fall to 93.4% and 73.4%, while incidence appeared slight rebound. During this period, age-specific antibody positive rate of 1–14 years was between 85.7% and 100%, except 68.6%-80.0% in 2003. Range of antibody positive rate in infants <1 years was 30.0%-61.2% (Figure 7).

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

View Article: PubMed Central - HTML - PubMed

Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

Show MeSH
Related in: MedlinePlus