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A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

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Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

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Measles Incidence and immunization coverage rate in Beijing, 1971–2011.
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Figure 6: Measles Incidence and immunization coverage rate in Beijing, 1971–2011.

Mentions: From 1971 to 1977, the MV coverage rate of first dose increased from 71.2% to 88.6%, while measles incidence remained high level during this period. During period of planned vaccination in 1978–1996, the MV coverage rate of first and second doses increased gradually from 91.2% to 99.9%, and measles incidence in entire population decreased dramatically from 146.0/100,000 to 0.3/100,000 and incidence in children of 1–14 years also declined greatly from 616.7/100,00, to 0.1/100,000. During accelerated period of measles control from 1997–2004, the MV coverage rate of second dose appeared a decline around 88.4% -94.5% in 2002–2004, which was probably related to rebound of measles incidence of whole population and children of 1–14 years in 2005 (Figure 6).


A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Measles Incidence and immunization coverage rate in Beijing, 1971–2011.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016557&req=5

Figure 6: Measles Incidence and immunization coverage rate in Beijing, 1971–2011.
Mentions: From 1971 to 1977, the MV coverage rate of first dose increased from 71.2% to 88.6%, while measles incidence remained high level during this period. During period of planned vaccination in 1978–1996, the MV coverage rate of first and second doses increased gradually from 91.2% to 99.9%, and measles incidence in entire population decreased dramatically from 146.0/100,000 to 0.3/100,000 and incidence in children of 1–14 years also declined greatly from 616.7/100,00, to 0.1/100,000. During accelerated period of measles control from 1997–2004, the MV coverage rate of second dose appeared a decline around 88.4% -94.5% in 2002–2004, which was probably related to rebound of measles incidence of whole population and children of 1–14 years in 2005 (Figure 6).

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

View Article: PubMed Central - HTML - PubMed

Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

Show MeSH
Related in: MedlinePlus