Limits...
A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

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Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

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Spatiotemporal distribution of measles incidence in different stages, 1982–2011.
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Figure 4: Spatiotemporal distribution of measles incidence in different stages, 1982–2011.

Mentions: Measles was observed in all districts in Beijing, while the spatial distribution varied from 1982 to 2011 (Figure 4). In 1982–1985, measles broke out in all districts and the incidence range from 38.3/100,000 to 160.2/100,000. In 1986–1996, measles incidence decreased dramatically in all districts, ranging from 0.2/100,000 to 3.6/100,000. In 1997–2004, incidence of all districts remained lower level at 0.1/100,000 to 10.5/100,000. In 2005–2010, incidence in all districts increased slightly from 2.1/100,000 to 27.3/100,000. The main high risk districts were Chaoyang, Fengtai and Changping. After MV SIAs in 2010, incidence in all districts declined dramatically to lowest level, which was 0 in three districts.


A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Spatiotemporal distribution of measles incidence in different stages, 1982–2011.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016557&req=5

Figure 4: Spatiotemporal distribution of measles incidence in different stages, 1982–2011.
Mentions: Measles was observed in all districts in Beijing, while the spatial distribution varied from 1982 to 2011 (Figure 4). In 1982–1985, measles broke out in all districts and the incidence range from 38.3/100,000 to 160.2/100,000. In 1986–1996, measles incidence decreased dramatically in all districts, ranging from 0.2/100,000 to 3.6/100,000. In 1997–2004, incidence of all districts remained lower level at 0.1/100,000 to 10.5/100,000. In 2005–2010, incidence in all districts increased slightly from 2.1/100,000 to 27.3/100,000. The main high risk districts were Chaoyang, Fengtai and Changping. After MV SIAs in 2010, incidence in all districts declined dramatically to lowest level, which was 0 in three districts.

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

View Article: PubMed Central - HTML - PubMed

Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

Show MeSH
Related in: MedlinePlus