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A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

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Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

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Age-specific incidence and proportion of measles in Beijing, 1957–2011. The measles cases by age groups in 1963–1972, 1985–1986 and 1997–1999 and the age-specific incidence in 1963–1977, 1985–1986 and 1997–1999 were not recorded in detail.
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Figure 3: Age-specific incidence and proportion of measles in Beijing, 1957–2011. The measles cases by age groups in 1963–1972, 1985–1986 and 1997–1999 and the age-specific incidence in 1963–1977, 1985–1986 and 1997–1999 were not recorded in detail.

Mentions: Age-specific incidence of measles varied over time. In 1957–1962 prior to vaccination, high measles incidence, 685.5/100,000 to 14,743.2/100,000, was found in children aged ≤14 years, especially among children aged 1–2 years. Incidence decreased gradually by age. After the introduction of initial planned vaccination in 1978–1984, incidence decreased dramatically from 237.0/100,000 to 465.3/100,000 in children aged ≤14 years. In 1987–1996, incidence declined continually in all age groups, ranging from 0.1/100,000 to 6.4/100,000. Since this period, age-specific incidence showed a change, three peaks of higher incidence were found in infants of <1 years, children of 5–7 years and adults of 20–30 years. In 2000–2004, incidence increased in all age groups, ranging from 3.6/100,000 to 61.5/100,000 for children aged ≤14 years and 1.1/100,000 to 11.9/100,000 for adults aged ≥15 years, with two crest in infants of <1 years and adults of 20–30 years. In 2005–2010, age-specific incidence increased to 5.1/100,000-82.9/100,.000 for children aged ≤14 years and 2.3/100,000-28.0/100,000 for adults aged ≥15 years, with highest 373.0/100,000 in infants aged <1 years. After MV SIA in 2010, incidence declined greatly to 0–1.2/100,000 for ≥2 years age group, while incidence was 29.9/100,000 for <1 years age group and 5.8/100,000 for 1–2 years age group (Figure 3).


A 60-year review on the changing epidemiology of measles in capital Beijing, China, 1951-2011.

Li J, Lu L, Pang X, Sun M, Ma R, Liu D, Wu J - BMC Public Health (2013)

Age-specific incidence and proportion of measles in Beijing, 1957–2011. The measles cases by age groups in 1963–1972, 1985–1986 and 1997–1999 and the age-specific incidence in 1963–1977, 1985–1986 and 1997–1999 were not recorded in detail.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016557&req=5

Figure 3: Age-specific incidence and proportion of measles in Beijing, 1957–2011. The measles cases by age groups in 1963–1972, 1985–1986 and 1997–1999 and the age-specific incidence in 1963–1977, 1985–1986 and 1997–1999 were not recorded in detail.
Mentions: Age-specific incidence of measles varied over time. In 1957–1962 prior to vaccination, high measles incidence, 685.5/100,000 to 14,743.2/100,000, was found in children aged ≤14 years, especially among children aged 1–2 years. Incidence decreased gradually by age. After the introduction of initial planned vaccination in 1978–1984, incidence decreased dramatically from 237.0/100,000 to 465.3/100,000 in children aged ≤14 years. In 1987–1996, incidence declined continually in all age groups, ranging from 0.1/100,000 to 6.4/100,000. Since this period, age-specific incidence showed a change, three peaks of higher incidence were found in infants of <1 years, children of 5–7 years and adults of 20–30 years. In 2000–2004, incidence increased in all age groups, ranging from 3.6/100,000 to 61.5/100,000 for children aged ≤14 years and 1.1/100,000 to 11.9/100,000 for adults aged ≥15 years, with two crest in infants of <1 years and adults of 20–30 years. In 2005–2010, age-specific incidence increased to 5.1/100,000-82.9/100,.000 for children aged ≤14 years and 2.3/100,000-28.0/100,000 for adults aged ≥15 years, with highest 373.0/100,000 in infants aged <1 years. After MV SIA in 2010, incidence declined greatly to 0–1.2/100,000 for ≥2 years age group, while incidence was 29.9/100,000 for <1 years age group and 5.8/100,000 for 1–2 years age group (Figure 3).

Bottom Line: Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010.Measles antibody positive rate was 85%-95% in most of years since 1981.High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years.

View Article: PubMed Central - HTML - PubMed

Affiliation: Beijing Center for Disease Control and Prevention, 16 Hepingli Middle Road, Dongcheng District, Beijing 100013, China. wj81732@yahoo.com.cn.

ABSTRACT

Background: China pledged to join the global effort to eliminate measles by 2012. To improve measles control strategy, the epidemic trend and population immunity of measles were investigated in 1951-2011 in Beijing.

Methods: The changing trend of measles since 1951 was described based on measles surveillance data from Beijing Centre of Disease Control and Prevention (CDC). The measles vaccination coverage and antibody level were assessed by routinely reported measles vaccination data and twenty-one sero-epidemiological surveys.

Results: The incidence of measles has decreased significantly from 593.5/100,000 in 1951 (peaked at 2721.0/100,000 in 1955), to 0.5/100,000 in 2011 due to increasing vaccination coverage of 95%-99%. Incidence rebounded from 6.6/100,000 to 24.5/100,000 since 2005 and decreased after measles vaccine (MV) supplementary immunization activities (SIAs) in 2010. Measles antibody positive rate was 85%-95% in most of years since 1981. High-risk districts were spotted in Chaoyang, Fengtai and Changping districts in recent 15 years. Age-specific incidence and proportion of measles varied over time. The most affected population were younger children of 1-4 years before 1978, older children of 5-14 years in 1978-1996, infant of <1 years and adults of ≥15 years in period of aim to measles elimination.

Conclusion: Strategies at different stages had a prevailing effect on the epidemic dynamics of measles in recent 60 years in Beijing. It will be essential to validate reported vaccination coverage, improve vaccination coverage in adults and strengthen measles surveillance in the anticipated elimination campaign for measles.

Show MeSH
Related in: MedlinePlus