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Cold Atmospheric Plasma: methods of production and application in dentistry and oncology.

Hoffmann C, Berganza C, Zhang J - Med Gas Res (2013)

Bottom Line: In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens.It has been shown that reactive oxidative species, charged particles, and UV photons play the main role.This unique finding opens up its potential therapy in oncology.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA 92354, USA. johnzhang3910@yahoo.com.

ABSTRACT
Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology.

No MeSH data available.


Related in: MedlinePlus

The different components of a tooth[153].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4016545&req=5

Figure 5: The different components of a tooth[153].

Mentions: The mouth is a microbial habitat with over 700 species that live in harmony with the human body [85]. However, periodontal disease and caries are the two most common diseases in dentistry. Every year, $60 Billion is spent in the United States to treat dental disease. Dental caries are defined as the localized destruction of tooth tissue by the acids produced by bacteria. [86]. Caries start with small demineralization areas under the enamel. The demineralization can progress through the dentine and to the pulp (Figure 5). S. mutans is one of the major causes of caries [87]. Before filling cavities, necrotic, infected, and demineralized tissue is removed by using ozone treatment, mechanical drilling, or laser techniques [88-95]. Unfortunately, these methods can be destructive as they might remove an excess of healthy tissue to make sure that the cavity is bacteria free. Periodontal disease is related to dental plaque, which is a complex oral biofilm with several microbial species organized in communities [96]. It leads to the detachment of the gum from the tooth as a result of inflammation, which is the body’s natural response to dental plaque. Several authors have been studying possible use of CAP on dental bleaching, dental disinfection, biofilm removal, instrument sterilization, and composite restoration (See list of different uses of CAP in dentistry section).


Cold Atmospheric Plasma: methods of production and application in dentistry and oncology.

Hoffmann C, Berganza C, Zhang J - Med Gas Res (2013)

The different components of a tooth[153].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016545&req=5

Figure 5: The different components of a tooth[153].
Mentions: The mouth is a microbial habitat with over 700 species that live in harmony with the human body [85]. However, periodontal disease and caries are the two most common diseases in dentistry. Every year, $60 Billion is spent in the United States to treat dental disease. Dental caries are defined as the localized destruction of tooth tissue by the acids produced by bacteria. [86]. Caries start with small demineralization areas under the enamel. The demineralization can progress through the dentine and to the pulp (Figure 5). S. mutans is one of the major causes of caries [87]. Before filling cavities, necrotic, infected, and demineralized tissue is removed by using ozone treatment, mechanical drilling, or laser techniques [88-95]. Unfortunately, these methods can be destructive as they might remove an excess of healthy tissue to make sure that the cavity is bacteria free. Periodontal disease is related to dental plaque, which is a complex oral biofilm with several microbial species organized in communities [96]. It leads to the detachment of the gum from the tooth as a result of inflammation, which is the body’s natural response to dental plaque. Several authors have been studying possible use of CAP on dental bleaching, dental disinfection, biofilm removal, instrument sterilization, and composite restoration (See list of different uses of CAP in dentistry section).

Bottom Line: In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens.It has been shown that reactive oxidative species, charged particles, and UV photons play the main role.This unique finding opens up its potential therapy in oncology.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA 92354, USA. johnzhang3910@yahoo.com.

ABSTRACT
Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology.

No MeSH data available.


Related in: MedlinePlus