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Cold Atmospheric Plasma: methods of production and application in dentistry and oncology.

Hoffmann C, Berganza C, Zhang J - Med Gas Res (2013)

Bottom Line: In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens.It has been shown that reactive oxidative species, charged particles, and UV photons play the main role.This unique finding opens up its potential therapy in oncology.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA 92354, USA. johnzhang3910@yahoo.com.

ABSTRACT
Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology.

No MeSH data available.


Related in: MedlinePlus

A schematic of the plasma pencil created by Laroussi et al.
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Figure 4: A schematic of the plasma pencil created by Laroussi et al.

Mentions: Laroussi et al. developed a miniature jet that they called plasma pencil [54]. It consists of a dielectric cylindrical tube of 2.5 cm in diameter where two disk electrodes of the same diameter as the tube are inserted. The two electrodes are separated by a gap (the distance can vary from 0.3 to 1 cm) and consist of a thin copper ring attached to a dielectric disk. To create the plasma, sub-microsecond high voltage pulses are applied between the two electrodes while a gas is injected through the holes of the electrodes. When the discharge is created, a plasma plume is launched through the hole of the outer electrode into the air. Because the plasma plume (up to 5cm in length) remains at low temperature (290K), it can be touched safely. The electrical power is supplied to the electrodes by a high voltage pulse generator. The high voltage is supplied to the pulse generator by a DC voltage supply with variable output. The plasma pencil has been used in the treatment of E. coli, Leukemia cells, and P. Gingivalis[55-57]. Forster et al., Zhang et al., and Wash et al. developed a plasma jet using a DBD configuration (Figure 4) [58-60].


Cold Atmospheric Plasma: methods of production and application in dentistry and oncology.

Hoffmann C, Berganza C, Zhang J - Med Gas Res (2013)

A schematic of the plasma pencil created by Laroussi et al.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016545&req=5

Figure 4: A schematic of the plasma pencil created by Laroussi et al.
Mentions: Laroussi et al. developed a miniature jet that they called plasma pencil [54]. It consists of a dielectric cylindrical tube of 2.5 cm in diameter where two disk electrodes of the same diameter as the tube are inserted. The two electrodes are separated by a gap (the distance can vary from 0.3 to 1 cm) and consist of a thin copper ring attached to a dielectric disk. To create the plasma, sub-microsecond high voltage pulses are applied between the two electrodes while a gas is injected through the holes of the electrodes. When the discharge is created, a plasma plume is launched through the hole of the outer electrode into the air. Because the plasma plume (up to 5cm in length) remains at low temperature (290K), it can be touched safely. The electrical power is supplied to the electrodes by a high voltage pulse generator. The high voltage is supplied to the pulse generator by a DC voltage supply with variable output. The plasma pencil has been used in the treatment of E. coli, Leukemia cells, and P. Gingivalis[55-57]. Forster et al., Zhang et al., and Wash et al. developed a plasma jet using a DBD configuration (Figure 4) [58-60].

Bottom Line: In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens.It has been shown that reactive oxidative species, charged particles, and UV photons play the main role.This unique finding opens up its potential therapy in oncology.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA 92354, USA. johnzhang3910@yahoo.com.

ABSTRACT
Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology.

No MeSH data available.


Related in: MedlinePlus