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Association between erythrocyte parameters and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.

Wu S, Lin H, Zhang C, Zhang Q, Zhang D, Zhang Y, Meng W, Zhu Z, Tang F, Xue F, Liu Y - BMC Public Health (2013)

Bottom Line: Both RBC and Hb were strongly associated with MetS (RR/95% CI, P value; 3.016/1.525-5.967, 0.002 for RBC; 3.008/1.481-6.109, 0.002 for Hb), with their dose-response trends detected.All three erythrocyte parameters (RBC, Hb and HCT) were found to be associated with obesity, hypertension and dyslipidemia with similar dose-response trends respectively, while only Hb showed a significant association with hyperglycemia.Elevated erythrocyte parameters were confirmed to be associated with MetS/its components in urban Chinese population, suggesting that erythrocyte parameters might be served as a potential predictor for risk of MetS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. liu-yx@sdu.edu.cn.

ABSTRACT

Background: Although various cross-sectional studies have shown that erythrocyte parameters, including red blood cell (RBC), hemoglobin (Hb) and hematocrit (HCT), were linked with metabolic syndrome (MetS), few longitudinal studies have been used to confirm their relationship. The study, therefore, constructed a large-scale longitudinal cohort in urban Chinese population to highlight and confirm the association between erythrocyte parameters and MetS/its components.

Methods: A longitudinal cohort with 6,453 participants was established based on the routine health check-up systems to follow up MetS, and Generalized Estimating Equation (GEE) model was used to detect the association between erythrocyte parameters and MetS/its components (obesity, hyperglycemia, dyslipidemia, and hypertension).

Results: 287 MetS occurred over the four-year follow-up, leading to a total incidence density of 14.19 per 1,000 person-years (287/20218 person-years). Both RBC and Hb were strongly associated with MetS (RR/95% CI, P value; 3.016/1.525-5.967, 0.002 for RBC; 3.008/1.481-6.109, 0.002 for Hb), with their dose-response trends detected. All three erythrocyte parameters (RBC, Hb and HCT) were found to be associated with obesity, hypertension and dyslipidemia with similar dose-response trends respectively, while only Hb showed a significant association with hyperglycemia.

Conclusions: Elevated erythrocyte parameters were confirmed to be associated with MetS/its components in urban Chinese population, suggesting that erythrocyte parameters might be served as a potential predictor for risk of MetS.

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Related in: MedlinePlus

The samples of repeated surveys at each year.
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Figure 1: The samples of repeated surveys at each year.

Mentions: A large scale longitudinal cohort was set up in 2005 on middle-to-upper class urban Han Chinese who attended routine health check-up at the Centers for Health Management of Shandong Provincial Hospital and Shandong Provincial Qianfoshan Hospital. Four groups of participants without cerebral infarction, cardiovascular disease, coronary artery bypass surgery, MetS and its single component in their first check-up at the year of 2005, 2006, 2007 and 2008 were included in the baseline of our longitudinal cohort study respectively. FigureĀ 1 showed the total of 6453 participants having at least three repeated health check-up within five years (January 2005 to January 2010), and the samples of repeated surveys each year.


Association between erythrocyte parameters and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.

Wu S, Lin H, Zhang C, Zhang Q, Zhang D, Zhang Y, Meng W, Zhu Z, Tang F, Xue F, Liu Y - BMC Public Health (2013)

The samples of repeated surveys at each year.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016498&req=5

Figure 1: The samples of repeated surveys at each year.
Mentions: A large scale longitudinal cohort was set up in 2005 on middle-to-upper class urban Han Chinese who attended routine health check-up at the Centers for Health Management of Shandong Provincial Hospital and Shandong Provincial Qianfoshan Hospital. Four groups of participants without cerebral infarction, cardiovascular disease, coronary artery bypass surgery, MetS and its single component in their first check-up at the year of 2005, 2006, 2007 and 2008 were included in the baseline of our longitudinal cohort study respectively. FigureĀ 1 showed the total of 6453 participants having at least three repeated health check-up within five years (January 2005 to January 2010), and the samples of repeated surveys each year.

Bottom Line: Both RBC and Hb were strongly associated with MetS (RR/95% CI, P value; 3.016/1.525-5.967, 0.002 for RBC; 3.008/1.481-6.109, 0.002 for Hb), with their dose-response trends detected.All three erythrocyte parameters (RBC, Hb and HCT) were found to be associated with obesity, hypertension and dyslipidemia with similar dose-response trends respectively, while only Hb showed a significant association with hyperglycemia.Elevated erythrocyte parameters were confirmed to be associated with MetS/its components in urban Chinese population, suggesting that erythrocyte parameters might be served as a potential predictor for risk of MetS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. liu-yx@sdu.edu.cn.

ABSTRACT

Background: Although various cross-sectional studies have shown that erythrocyte parameters, including red blood cell (RBC), hemoglobin (Hb) and hematocrit (HCT), were linked with metabolic syndrome (MetS), few longitudinal studies have been used to confirm their relationship. The study, therefore, constructed a large-scale longitudinal cohort in urban Chinese population to highlight and confirm the association between erythrocyte parameters and MetS/its components.

Methods: A longitudinal cohort with 6,453 participants was established based on the routine health check-up systems to follow up MetS, and Generalized Estimating Equation (GEE) model was used to detect the association between erythrocyte parameters and MetS/its components (obesity, hyperglycemia, dyslipidemia, and hypertension).

Results: 287 MetS occurred over the four-year follow-up, leading to a total incidence density of 14.19 per 1,000 person-years (287/20218 person-years). Both RBC and Hb were strongly associated with MetS (RR/95% CI, P value; 3.016/1.525-5.967, 0.002 for RBC; 3.008/1.481-6.109, 0.002 for Hb), with their dose-response trends detected. All three erythrocyte parameters (RBC, Hb and HCT) were found to be associated with obesity, hypertension and dyslipidemia with similar dose-response trends respectively, while only Hb showed a significant association with hyperglycemia.

Conclusions: Elevated erythrocyte parameters were confirmed to be associated with MetS/its components in urban Chinese population, suggesting that erythrocyte parameters might be served as a potential predictor for risk of MetS.

Show MeSH
Related in: MedlinePlus