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Association of mTOR polymorphisms with cancer risk and clinical outcomes: a meta-analysis.

Shao J, Li Y, Zhao P, Yue X, Jiang J, Liang X, He X - PLoS ONE (2014)

Bottom Line: However, inconsistent results have been reported.In conclusion, this meta-analysis indicated the common polymorphisms in mTOR gene might be genetic risk factors for the carcinogenesis and clinical outcomes of cancer patients.However, further investigation on large population and different ethnicities are warranted.

View Article: PubMed Central - PubMed

Affiliation: Department of CT/MRI, Wuhan Children's Hospital, Hubei, China.

ABSTRACT
Genetic polymorphisms in mTOR gene may be associated with cancer risk and clinical outcomes of cancer patients by affecting mTOR gene expression or its activation. However, inconsistent results have been reported. The aim of this study is to systematically evaluate the association between mTOR polymorphisms (rs2295080, rs2536 and rs11121704) and cancer risk as well as clinical outcome by a meta-analysis. We identified 10 eligible studies and extracted data by two investigators. Based on dominant and recessive models, odds ratio (ORs) and 95% confidence intervals (CIs) were calculated by using Stata, version 11 to evaluate the association strength. Our meta-analysis results showed that the wild genotype TT of rs2295080 polymorphism was associated with increased cancer risk under dominant model (OR = 1.24, 95%CI: 1.12-1.36, p<0.0005) in Chinese but not with clinical outcome parameters, while the TT genotype of rs11121704 was associated with poor clinical outcome parameters (OR = 1.53, 95%CI: 1.01-2.32, p = 0.044), such as death, metastasis and resistance to chemotherapy. However, rs2536 may not influence cancer susceptibility. In conclusion, this meta-analysis indicated the common polymorphisms in mTOR gene might be genetic risk factors for the carcinogenesis and clinical outcomes of cancer patients. However, further investigation on large population and different ethnicities are warranted.

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Related in: MedlinePlus

Funnel plots to detect publication bias.Each point represents an independent study for the indicated association.
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pone-0097085-g004: Funnel plots to detect publication bias.Each point represents an independent study for the indicated association.

Mentions: Begg's funnel plot and Egger's test were performed to evaluate the publication bias of literatures. The shapes of the funnel plots did not reveal any evidence of obvious asymmetry except for the association of rs2295080 and rs2536 with cancer risk under the recessive model, and the Egger's test also suggested that there was slight publication bias for the latter (p = 0.045) (Fig. 4). In addition, although symmetrical funnel plots were obtained under the recessive model for the association of mTOR polymorphisms with clinical outcomes, the Egger's test indicated publication bias was present for rs2295080 polymorphism (p = 0.041) (Fig. 4). After adjusted by “trim and fill” method did not significantly influence the results from our meta-analysis (OR = 0.99, 95%CI: 0.52–1.47).


Association of mTOR polymorphisms with cancer risk and clinical outcomes: a meta-analysis.

Shao J, Li Y, Zhao P, Yue X, Jiang J, Liang X, He X - PLoS ONE (2014)

Funnel plots to detect publication bias.Each point represents an independent study for the indicated association.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016248&req=5

pone-0097085-g004: Funnel plots to detect publication bias.Each point represents an independent study for the indicated association.
Mentions: Begg's funnel plot and Egger's test were performed to evaluate the publication bias of literatures. The shapes of the funnel plots did not reveal any evidence of obvious asymmetry except for the association of rs2295080 and rs2536 with cancer risk under the recessive model, and the Egger's test also suggested that there was slight publication bias for the latter (p = 0.045) (Fig. 4). In addition, although symmetrical funnel plots were obtained under the recessive model for the association of mTOR polymorphisms with clinical outcomes, the Egger's test indicated publication bias was present for rs2295080 polymorphism (p = 0.041) (Fig. 4). After adjusted by “trim and fill” method did not significantly influence the results from our meta-analysis (OR = 0.99, 95%CI: 0.52–1.47).

Bottom Line: However, inconsistent results have been reported.In conclusion, this meta-analysis indicated the common polymorphisms in mTOR gene might be genetic risk factors for the carcinogenesis and clinical outcomes of cancer patients.However, further investigation on large population and different ethnicities are warranted.

View Article: PubMed Central - PubMed

Affiliation: Department of CT/MRI, Wuhan Children's Hospital, Hubei, China.

ABSTRACT
Genetic polymorphisms in mTOR gene may be associated with cancer risk and clinical outcomes of cancer patients by affecting mTOR gene expression or its activation. However, inconsistent results have been reported. The aim of this study is to systematically evaluate the association between mTOR polymorphisms (rs2295080, rs2536 and rs11121704) and cancer risk as well as clinical outcome by a meta-analysis. We identified 10 eligible studies and extracted data by two investigators. Based on dominant and recessive models, odds ratio (ORs) and 95% confidence intervals (CIs) were calculated by using Stata, version 11 to evaluate the association strength. Our meta-analysis results showed that the wild genotype TT of rs2295080 polymorphism was associated with increased cancer risk under dominant model (OR = 1.24, 95%CI: 1.12-1.36, p<0.0005) in Chinese but not with clinical outcome parameters, while the TT genotype of rs11121704 was associated with poor clinical outcome parameters (OR = 1.53, 95%CI: 1.01-2.32, p = 0.044), such as death, metastasis and resistance to chemotherapy. However, rs2536 may not influence cancer susceptibility. In conclusion, this meta-analysis indicated the common polymorphisms in mTOR gene might be genetic risk factors for the carcinogenesis and clinical outcomes of cancer patients. However, further investigation on large population and different ethnicities are warranted.

Show MeSH
Related in: MedlinePlus