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Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae clone.

Ben-David D, Schwaber MJ, Adler A, Masarwa S, Edgar R, Navon-Venezia S, Schwartz D, Porat N, Kotlovsky T, Polivkin N, Weinberg I, Lazary A, Ohana N, Dagan R - Emerging Infect. Dis. (2014)

Bottom Line: We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction.Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone.The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

View Article: PubMed Central - PubMed

ABSTRACT
Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

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Serotyping and clonal analysis of the first point-prevalence survey of Streptococcus pneumoniae infection in a post–acute care facility, Israel, 2006–2011. FQ fluoroquinolone; ST, sequence type; FQISP, fluoroquinolone-intermediate S. pneumoniae; FQRSP fluoroquinolone-resistant S. pneumoniae.
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Figure 1: Serotyping and clonal analysis of the first point-prevalence survey of Streptococcus pneumoniae infection in a post–acute care facility, Israel, 2006–2011. FQ fluoroquinolone; ST, sequence type; FQISP, fluoroquinolone-intermediate S. pneumoniae; FQRSP fluoroquinolone-resistant S. pneumoniae.

Mentions: The FQRSP isolates belonged to 2 different serotypes and 3 different PFGE types (Figure 1). All belonged to a single ST (ST156). The 3 FQISP isolates from children belonged to serotype 19F. All belonged to a single clone that was different from the adult clone.


Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae clone.

Ben-David D, Schwaber MJ, Adler A, Masarwa S, Edgar R, Navon-Venezia S, Schwartz D, Porat N, Kotlovsky T, Polivkin N, Weinberg I, Lazary A, Ohana N, Dagan R - Emerging Infect. Dis. (2014)

Serotyping and clonal analysis of the first point-prevalence survey of Streptococcus pneumoniae infection in a post–acute care facility, Israel, 2006–2011. FQ fluoroquinolone; ST, sequence type; FQISP, fluoroquinolone-intermediate S. pneumoniae; FQRSP fluoroquinolone-resistant S. pneumoniae.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4012785&req=5

Figure 1: Serotyping and clonal analysis of the first point-prevalence survey of Streptococcus pneumoniae infection in a post–acute care facility, Israel, 2006–2011. FQ fluoroquinolone; ST, sequence type; FQISP, fluoroquinolone-intermediate S. pneumoniae; FQRSP fluoroquinolone-resistant S. pneumoniae.
Mentions: The FQRSP isolates belonged to 2 different serotypes and 3 different PFGE types (Figure 1). All belonged to a single ST (ST156). The 3 FQISP isolates from children belonged to serotype 19F. All belonged to a single clone that was different from the adult clone.

Bottom Line: We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction.Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone.The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

View Article: PubMed Central - PubMed

ABSTRACT
Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

Show MeSH
Related in: MedlinePlus