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Babesia venatorum Infection in Child, China.

Sun Y, Li SG, Jiang JF, Wang X, Zhang Y, Wang H, Cao WC - Emerging Infect. Dis. (2014)

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Although >100 Babesia species infect animals, only a few species, mainly B. microti and B. divergens, infect humans... Human infections with B. microti have been reported from the United States and other countries, and most human infections with B. divergens have been reported from Europe... Another species, B. venatorum, was found to infect humans in some countries in Europe... DNA was extracted from a patient blood sample... PCR specific for a partial 18S rRNA gene sequence was performed with primers PIRO-A and PIRO-B and showed a positive result for a Babesia sp... His clinical manifestations improved 3 days after treatment, although parasites were still detectable in blood smears... On May 17, negative results for blood smears and PCR indicated that the parasite had been cleared... All 3 case-patients were men >50 years of age who had undergone splenectomies for severe Hodgkin disease before Babesia sp. infection... The patient had no history of transfusions with blood products and had never traveled outside his home town before disease onset... Although he and his parents did not recall any tick bites, he was at high risk for exposure to ticks because he often played with his dog, which frequently went outdoors in a tick-infested forested area... The dog may have transmitted a Babesia sp. –infected tick to the patient... The patient in our study was presumed to be healthy and immunocompetent, which indicates that Babesia species can cause infections even in healthy persons... Babesiosis should be considered in the differential diagnosis of patients with a history of tick exposure and prolonged and irregular fever... The patient was treated with azithromycin and atovaquone and the parasites were cleared within 1 month... This combined treatment was well tolerated and effective, and it can be recommended as an alternative treatment to the commonly used therapy of quinine and clindamycin.

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A) Giemsa-stained thin blood smear for an 8-year-old boy from China showing erythrocytes with typical ring forms, paired pyriforms, and tetrads of a Babesia sp. (arrows). B) Giemsa-stained thin blood smear for a mouse with severely combined immunodeficiency, which had been injected with blood from the patient, showing Babesia sp.–infected erythrocytes (arrows). Original magnifications ×1,000.
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Figure 1: A) Giemsa-stained thin blood smear for an 8-year-old boy from China showing erythrocytes with typical ring forms, paired pyriforms, and tetrads of a Babesia sp. (arrows). B) Giemsa-stained thin blood smear for a mouse with severely combined immunodeficiency, which had been injected with blood from the patient, showing Babesia sp.–infected erythrocytes (arrows). Original magnifications ×1,000.

Mentions: A 0.5-mL blood sample obtained from the patient before treatment was injected intraperitoneally into 3 severely combined immunodeficient mice. Mice were monitored for parasitemia every 3 days. When tested 6–9 days postinjection, all 3 mice were positive for a Babesia sp. (Figure, panel B). We tested for IgG against B. venatorum and B. microti by using an indirect immunofluorescence assay (9). Seroconversion against B. venatorum was evident; reciprocal antibody titers of 16 in an acute-phase sample (admission) and 128 in a convalescent-phase (discharge) sample. Results for B. microti were negative.


Babesia venatorum Infection in Child, China.

Sun Y, Li SG, Jiang JF, Wang X, Zhang Y, Wang H, Cao WC - Emerging Infect. Dis. (2014)

A) Giemsa-stained thin blood smear for an 8-year-old boy from China showing erythrocytes with typical ring forms, paired pyriforms, and tetrads of a Babesia sp. (arrows). B) Giemsa-stained thin blood smear for a mouse with severely combined immunodeficiency, which had been injected with blood from the patient, showing Babesia sp.–infected erythrocytes (arrows). Original magnifications ×1,000.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4012784&req=5

Figure 1: A) Giemsa-stained thin blood smear for an 8-year-old boy from China showing erythrocytes with typical ring forms, paired pyriforms, and tetrads of a Babesia sp. (arrows). B) Giemsa-stained thin blood smear for a mouse with severely combined immunodeficiency, which had been injected with blood from the patient, showing Babesia sp.–infected erythrocytes (arrows). Original magnifications ×1,000.
Mentions: A 0.5-mL blood sample obtained from the patient before treatment was injected intraperitoneally into 3 severely combined immunodeficient mice. Mice were monitored for parasitemia every 3 days. When tested 6–9 days postinjection, all 3 mice were positive for a Babesia sp. (Figure, panel B). We tested for IgG against B. venatorum and B. microti by using an indirect immunofluorescence assay (9). Seroconversion against B. venatorum was evident; reciprocal antibody titers of 16 in an acute-phase sample (admission) and 128 in a convalescent-phase (discharge) sample. Results for B. microti were negative.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Although >100 Babesia species infect animals, only a few species, mainly B. microti and B. divergens, infect humans... Human infections with B. microti have been reported from the United States and other countries, and most human infections with B. divergens have been reported from Europe... Another species, B. venatorum, was found to infect humans in some countries in Europe... DNA was extracted from a patient blood sample... PCR specific for a partial 18S rRNA gene sequence was performed with primers PIRO-A and PIRO-B and showed a positive result for a Babesia sp... His clinical manifestations improved 3 days after treatment, although parasites were still detectable in blood smears... On May 17, negative results for blood smears and PCR indicated that the parasite had been cleared... All 3 case-patients were men >50 years of age who had undergone splenectomies for severe Hodgkin disease before Babesia sp. infection... The patient had no history of transfusions with blood products and had never traveled outside his home town before disease onset... Although he and his parents did not recall any tick bites, he was at high risk for exposure to ticks because he often played with his dog, which frequently went outdoors in a tick-infested forested area... The dog may have transmitted a Babesia sp. –infected tick to the patient... The patient in our study was presumed to be healthy and immunocompetent, which indicates that Babesia species can cause infections even in healthy persons... Babesiosis should be considered in the differential diagnosis of patients with a history of tick exposure and prolonged and irregular fever... The patient was treated with azithromycin and atovaquone and the parasites were cleared within 1 month... This combined treatment was well tolerated and effective, and it can be recommended as an alternative treatment to the commonly used therapy of quinine and clindamycin.

Show MeSH
Related in: MedlinePlus