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Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron.

Roemschied FA, Eberhard MJ, Schleimer JH, Ronacher B, Schreiber S - Elife (2014)

Bottom Line: The nervous systems of poikilothermic animals must have evolved mechanisms enabling them to retain their functionality under varying temperatures.Auditory receptor neurons of grasshoppers respond to sound in a surprisingly temperature-compensated manner: firing rates depend moderately on temperature, with average Q10 values around 1.5.Remarkably, this type of temperature compensation need not come at an additional metabolic cost of spike generation.

View Article: PubMed Central - PubMed

Affiliation: Institute of Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.

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Potassium-current based resting cost.(A) The distribution of the temperature dependence ( values) of the resting cost based on potassium-current across all spike generation models as well as models with particularly high and low RMSD (subgroup of models within the bottom and top 25 percentile of RMSDs). Overall, this type of resting cost increased with larger temperatures because A-type potassium currents were larger. (B) The temperature dependence of the leak conductance influenced this type of resting cost most.DOI:http://dx.doi.org/10.7554/eLife.02078.011
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fig3s2: Potassium-current based resting cost.(A) The distribution of the temperature dependence ( values) of the resting cost based on potassium-current across all spike generation models as well as models with particularly high and low RMSD (subgroup of models within the bottom and top 25 percentile of RMSDs). Overall, this type of resting cost increased with larger temperatures because A-type potassium currents were larger. (B) The temperature dependence of the leak conductance influenced this type of resting cost most.DOI:http://dx.doi.org/10.7554/eLife.02078.011

Mentions: The sodium-current based resting cost was qualitatively influenced in a similar way as temperature dependence of firing rate (Figure 3E): for all four relevant parameters a reduction of resting cost co-occurred with a reduction in temperature dependence of firing rate (same sign of corresponding impacts, Figure 2C). For a potassium-current based resting cost the temperature dependence of leak channels had the dominant impact (Figure 3—figure supplement 2). In contrast to the sodium-current based resting cost, the potassium-current-based cost was larger at higher temperatures. For the majority of models, inactivation of A-type potassium channels was lower at the higher temperature (due to a more negative resting potential) and hence increased the A-type current.


Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron.

Roemschied FA, Eberhard MJ, Schleimer JH, Ronacher B, Schreiber S - Elife (2014)

Potassium-current based resting cost.(A) The distribution of the temperature dependence ( values) of the resting cost based on potassium-current across all spike generation models as well as models with particularly high and low RMSD (subgroup of models within the bottom and top 25 percentile of RMSDs). Overall, this type of resting cost increased with larger temperatures because A-type potassium currents were larger. (B) The temperature dependence of the leak conductance influenced this type of resting cost most.DOI:http://dx.doi.org/10.7554/eLife.02078.011
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4012639&req=5

fig3s2: Potassium-current based resting cost.(A) The distribution of the temperature dependence ( values) of the resting cost based on potassium-current across all spike generation models as well as models with particularly high and low RMSD (subgroup of models within the bottom and top 25 percentile of RMSDs). Overall, this type of resting cost increased with larger temperatures because A-type potassium currents were larger. (B) The temperature dependence of the leak conductance influenced this type of resting cost most.DOI:http://dx.doi.org/10.7554/eLife.02078.011
Mentions: The sodium-current based resting cost was qualitatively influenced in a similar way as temperature dependence of firing rate (Figure 3E): for all four relevant parameters a reduction of resting cost co-occurred with a reduction in temperature dependence of firing rate (same sign of corresponding impacts, Figure 2C). For a potassium-current based resting cost the temperature dependence of leak channels had the dominant impact (Figure 3—figure supplement 2). In contrast to the sodium-current based resting cost, the potassium-current-based cost was larger at higher temperatures. For the majority of models, inactivation of A-type potassium channels was lower at the higher temperature (due to a more negative resting potential) and hence increased the A-type current.

Bottom Line: The nervous systems of poikilothermic animals must have evolved mechanisms enabling them to retain their functionality under varying temperatures.Auditory receptor neurons of grasshoppers respond to sound in a surprisingly temperature-compensated manner: firing rates depend moderately on temperature, with average Q10 values around 1.5.Remarkably, this type of temperature compensation need not come at an additional metabolic cost of spike generation.

View Article: PubMed Central - PubMed

Affiliation: Institute of Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.

Show MeSH
Related in: MedlinePlus