Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron.
Bottom Line: The nervous systems of poikilothermic animals must have evolved mechanisms enabling them to retain their functionality under varying temperatures.Auditory receptor neurons of grasshoppers respond to sound in a surprisingly temperature-compensated manner: firing rates depend moderately on temperature, with average Q10 values around 1.5.Remarkably, this type of temperature compensation need not come at an additional metabolic cost of spike generation.
Affiliation: Institute of Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.Show MeSH
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Mentions: The sodium-current based resting cost was qualitatively influenced in a similar way as temperature dependence of firing rate (Figure 3E): for all four relevant parameters a reduction of resting cost co-occurred with a reduction in temperature dependence of firing rate (same sign of corresponding impacts, Figure 2C). For a potassium-current based resting cost the temperature dependence of leak channels had the dominant impact (Figure 3—figure supplement 2). In contrast to the sodium-current based resting cost, the potassium-current-based cost was larger at higher temperatures. For the majority of models, inactivation of A-type potassium channels was lower at the higher temperature (due to a more negative resting potential) and hence increased the A-type current.
Affiliation: Institute of Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.