Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron.
Bottom Line: The nervous systems of poikilothermic animals must have evolved mechanisms enabling them to retain their functionality under varying temperatures.Auditory receptor neurons of grasshoppers respond to sound in a surprisingly temperature-compensated manner: firing rates depend moderately on temperature, with average Q10 values around 1.5.Remarkably, this type of temperature compensation need not come at an additional metabolic cost of spike generation.
Affiliation: Institute of Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.Show MeSH
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Mentions: To confirm that the results do not strongly depend on the specific choice of peak conductances in the Connor–Stevens model, we tested 24 alternative models with changes of ± 20% in the peak conductances of sodium, both potassium, and leak channels. The impact ranking across those models was highly similar to the ranking in the original Connor–Stevens model (Figure 2E) and we conclude that our results are robust. Moreover, we note that our results are not unique to the Connor–Stevens model. An analysis of a structurally different Traub–Miles model (Traub et al., 1991; Benda, 2002) showed that an equally low temperature dependence is possible (Figure 2—figure supplement 1).
Affiliation: Institute of Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.