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Association between urinary albumin excretion and intraocular pressure in type 2 diabetic patients without renal impairment.

Choi JA, Han K, Kwon HS - PLoS ONE (2014)

Bottom Line: Subjects with a high IOP ≥ 18 mmHg were more likely to be current smokers (P = 0.038), heavy drinkers (P = 0.006), and to have high systolic blood pressure (P = 0.016), triglycerides (P = 0.008), and a higher log-transformed ACR (P = 0.022).In multivariate regression analysis, ACR tertile was associated with the prevalence of high IOP significantly (P = 0.022).The associations between ACR tertiles and high IOP were significant in overweight patients and those with abdominal obesity (P = 0.003 and 0.003, respectively).The effect of the albuminuria on IOP was evident in a subgroup of patients with components of metabolic syndrome.

View Article: PubMed Central - PubMed

Affiliation: St. Vincent Hospital, Department of Ophthalmology, Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

ABSTRACT

Background: To assess the relationship between urinary albumin excretion and intraocular pressure (IOP) in type 2 diabetes patients without renal impairment.

Methods: We explored the effects of albuminuria on high IOP in 402 non-glaucomatous type 2 diabetes without renal impairment who participated in the 2011 Korean National Health and Nutrition Examination Survey (KNHANES). Multiple logistic regression analysis was used to assess the relationship between log-transformed albumin/creatinine ratio (ACR) tertiles and an IOP of ≥ 18 mmHg after adjusting for age, gender, hypertension, body mass index, triglycerides, area of residence, and education level.

Results: Subjects with a high IOP ≥ 18 mmHg were more likely to be current smokers (P = 0.038), heavy drinkers (P = 0.006), and to have high systolic blood pressure (P = 0.016), triglycerides (P = 0.008), and a higher log-transformed ACR (P = 0.022).In multivariate regression analysis, ACR tertile was associated with the prevalence of high IOP significantly (P = 0.022). The associations between ACR tertiles and high IOP were significant in overweight patients and those with abdominal obesity (P = 0.003 and 0.003, respectively). In contrast, there were no associations in the subgroup of patients who were not overweight and those without abdominal obesity (P = 0.291 and 0.561, respectively).

Conclusions: Urinary albumin excretion is associated with high IOP in the type 2 diabetes population without renal insufficiency. The effect of the albuminuria on IOP was evident in a subgroup of patients with components of metabolic syndrome.

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Prevalence of subjects (%) with high intraocular pressure (IOP; ≥18 mmHg) separated by albumin/creatinine ratio (ACR) tertiles (P for trend  = 0.020).
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pone-0096335-g001: Prevalence of subjects (%) with high intraocular pressure (IOP; ≥18 mmHg) separated by albumin/creatinine ratio (ACR) tertiles (P for trend  = 0.020).

Mentions: The study group consisted of 402 non-glaucomatous participants with type 2 DM, but without renal impairment. The mean age of the subjects was 55.43±0.86 years, and the mean BMI was 24.96±0.23 kg/m2. The mean hemoglobin A1c was 7.37±0.11%, and the mean duration of DM was 5.04±0.37 years. A comparison of the clinical and biochemical parameters of subjects with high (≥18 mmHg) and low IOP (<18 mmHg) is shown in Table 1. Subjects with high IOP were more likely to be current smokers (P = 0.038), current heavy drinkers (P = 0.006), have high systolic BP (P = 0.016), elevated TG (P = 0.008), and marginally high fasting serum glucose (P = 0.098). There was a significant difference in the log-transformed ACR (P = 0.022). The tertile cutoff values of ACR were as follows: T1 <3.38, 3.38≤T2<12.60, and T3 ≥12.60. The prevalence of subjects with high IOP was increased significantly in higher ACR tertiles (P = 0.020) (Figure 1). The results of multiple logistic regression analyses are shown in Table 2. ACR tertile was associated with the prevalence of high IOP significantly after adjusting for age and gender (P = 0.024); this was maintained after adjusting for the presence of hypertension, BMI, triglycerides, area of residence, and education level (P = 0.022). Additional adjustment for blood glucose level reduced the magnitude of the odds ratio for ocular hypertension, but did not affect their statistical significance (P = 0.043).


Association between urinary albumin excretion and intraocular pressure in type 2 diabetic patients without renal impairment.

Choi JA, Han K, Kwon HS - PLoS ONE (2014)

Prevalence of subjects (%) with high intraocular pressure (IOP; ≥18 mmHg) separated by albumin/creatinine ratio (ACR) tertiles (P for trend  = 0.020).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008590&req=5

pone-0096335-g001: Prevalence of subjects (%) with high intraocular pressure (IOP; ≥18 mmHg) separated by albumin/creatinine ratio (ACR) tertiles (P for trend  = 0.020).
Mentions: The study group consisted of 402 non-glaucomatous participants with type 2 DM, but without renal impairment. The mean age of the subjects was 55.43±0.86 years, and the mean BMI was 24.96±0.23 kg/m2. The mean hemoglobin A1c was 7.37±0.11%, and the mean duration of DM was 5.04±0.37 years. A comparison of the clinical and biochemical parameters of subjects with high (≥18 mmHg) and low IOP (<18 mmHg) is shown in Table 1. Subjects with high IOP were more likely to be current smokers (P = 0.038), current heavy drinkers (P = 0.006), have high systolic BP (P = 0.016), elevated TG (P = 0.008), and marginally high fasting serum glucose (P = 0.098). There was a significant difference in the log-transformed ACR (P = 0.022). The tertile cutoff values of ACR were as follows: T1 <3.38, 3.38≤T2<12.60, and T3 ≥12.60. The prevalence of subjects with high IOP was increased significantly in higher ACR tertiles (P = 0.020) (Figure 1). The results of multiple logistic regression analyses are shown in Table 2. ACR tertile was associated with the prevalence of high IOP significantly after adjusting for age and gender (P = 0.024); this was maintained after adjusting for the presence of hypertension, BMI, triglycerides, area of residence, and education level (P = 0.022). Additional adjustment for blood glucose level reduced the magnitude of the odds ratio for ocular hypertension, but did not affect their statistical significance (P = 0.043).

Bottom Line: Subjects with a high IOP ≥ 18 mmHg were more likely to be current smokers (P = 0.038), heavy drinkers (P = 0.006), and to have high systolic blood pressure (P = 0.016), triglycerides (P = 0.008), and a higher log-transformed ACR (P = 0.022).In multivariate regression analysis, ACR tertile was associated with the prevalence of high IOP significantly (P = 0.022).The associations between ACR tertiles and high IOP were significant in overweight patients and those with abdominal obesity (P = 0.003 and 0.003, respectively).The effect of the albuminuria on IOP was evident in a subgroup of patients with components of metabolic syndrome.

View Article: PubMed Central - PubMed

Affiliation: St. Vincent Hospital, Department of Ophthalmology, Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

ABSTRACT

Background: To assess the relationship between urinary albumin excretion and intraocular pressure (IOP) in type 2 diabetes patients without renal impairment.

Methods: We explored the effects of albuminuria on high IOP in 402 non-glaucomatous type 2 diabetes without renal impairment who participated in the 2011 Korean National Health and Nutrition Examination Survey (KNHANES). Multiple logistic regression analysis was used to assess the relationship between log-transformed albumin/creatinine ratio (ACR) tertiles and an IOP of ≥ 18 mmHg after adjusting for age, gender, hypertension, body mass index, triglycerides, area of residence, and education level.

Results: Subjects with a high IOP ≥ 18 mmHg were more likely to be current smokers (P = 0.038), heavy drinkers (P = 0.006), and to have high systolic blood pressure (P = 0.016), triglycerides (P = 0.008), and a higher log-transformed ACR (P = 0.022).In multivariate regression analysis, ACR tertile was associated with the prevalence of high IOP significantly (P = 0.022). The associations between ACR tertiles and high IOP were significant in overweight patients and those with abdominal obesity (P = 0.003 and 0.003, respectively). In contrast, there were no associations in the subgroup of patients who were not overweight and those without abdominal obesity (P = 0.291 and 0.561, respectively).

Conclusions: Urinary albumin excretion is associated with high IOP in the type 2 diabetes population without renal insufficiency. The effect of the albuminuria on IOP was evident in a subgroup of patients with components of metabolic syndrome.

Show MeSH
Related in: MedlinePlus