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Validation of a French version of the quality of life "Celiac Disease Questionnaire".

Pouchot J, Despujol C, Malamut G, Ecosse E, Coste J, Cellier C - PLoS ONE (2014)

Bottom Line: Both the manifestations of the disease and the burden of the compulsory life-long gluten-free diet (GFD) have been shown to be associated with impairment of health-related quality of life.Reliability (intraclass correlation coefficients (ICC), Cronbach's alpha and Bland and Altman graphical analysis), validity (factorial structure and Rasch analysis, convergent validity), and responsiveness (effect size) of the F-CDQ were studied.Responsiveness was studied and effect sizes ≥ 0.20 were demonstrated for most of the subscales for patients who reported improvement or deterioration after 6 months.

View Article: PubMed Central - PubMed

Affiliation: Service de médecine interne, hôpital européen Georges Pompidou, Assistance Publiques - Hôpitaux de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; APEMAC, EA 4360, Université de Lorraine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

ABSTRACT

Background and objective: Celiac disease (CD) is a common chronic autoimmune disorder. Both the manifestations of the disease and the burden of the compulsory life-long gluten-free diet (GFD) have been shown to be associated with impairment of health-related quality of life. The objectives of this study were to provide a cross-cultural adaptation of the specific quality of life "Celiac Disease Questionnaire" (CDQ) and to analyze its psychometric properties.

Materials and methods: A cross-cultural French adaptation of the CDQ (F-CDQ) was obtained according to the revised international guidelines. The questionnaire was administered at baseline to 211 patients with biopsy proven CD followed-up in a single tertiary referral centre. The questionnaire was also administered after 7 days and 6 months. Reliability (intraclass correlation coefficients (ICC), Cronbach's alpha and Bland and Altman graphical analysis), validity (factorial structure and Rasch analysis, convergent validity), and responsiveness (effect size) of the F-CDQ were studied.

Results: The reliability of the F-CDQ was excellent with ICC and Cronbach's alpha coefficients being between 0.79 and 0.94 for the four subscales and the total score. The factorial structure and the Rasch analysis showed that the four dimensions of the original instrument were retained. Correlations with external measures (a generic measure of quality of life, an anxiety and depression instrument, a self-assessed disease severity, and clinical manifestations) were all in the expected direction confirming the validity of the instrument. Responsiveness was studied and effect sizes ≥ 0.20 were demonstrated for most of the subscales for patients who reported improvement or deterioration after 6 months.

Conclusion: The F-CDQ retains the psychometric properties of the original instrument and should be useful in cross-national surveys and to assess outcome in clinical trials involving patients with CD.

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Related in: MedlinePlus

Bland and Altman graphical analysis of the reproducibility of the total score of the French version of the “Celiac Disease Questionnaire” (F-CDQ).Mean total score of the two F-CDQ assessments (baseline and retest 7 days later for patients who stated that their health status was unchanged) plotted against the difference of these two measures. The horizontal dotted lines indicate the mean difference ± 1 SD.
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pone-0096346-g001: Bland and Altman graphical analysis of the reproducibility of the total score of the French version of the “Celiac Disease Questionnaire” (F-CDQ).Mean total score of the two F-CDQ assessments (baseline and retest 7 days later for patients who stated that their health status was unchanged) plotted against the difference of these two measures. The horizontal dotted lines indicate the mean difference ± 1 SD.

Mentions: Of the 211 patients who completed the initial assessment, 144 completed the 7-day assessment, and of these, 112 stated that their CD-related health status had not changed significantly. The intraclass correlation coefficients for the 4 subscales were 0.88 to 0.94 (Table 2), indicating excellent reproducibility. The graphical method of Bland and Altman also revealed an excellent reproducibility throughout the range the F-CDQ total score (Figure 1) and the four subscales (not shown).


Validation of a French version of the quality of life "Celiac Disease Questionnaire".

Pouchot J, Despujol C, Malamut G, Ecosse E, Coste J, Cellier C - PLoS ONE (2014)

Bland and Altman graphical analysis of the reproducibility of the total score of the French version of the “Celiac Disease Questionnaire” (F-CDQ).Mean total score of the two F-CDQ assessments (baseline and retest 7 days later for patients who stated that their health status was unchanged) plotted against the difference of these two measures. The horizontal dotted lines indicate the mean difference ± 1 SD.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008531&req=5

pone-0096346-g001: Bland and Altman graphical analysis of the reproducibility of the total score of the French version of the “Celiac Disease Questionnaire” (F-CDQ).Mean total score of the two F-CDQ assessments (baseline and retest 7 days later for patients who stated that their health status was unchanged) plotted against the difference of these two measures. The horizontal dotted lines indicate the mean difference ± 1 SD.
Mentions: Of the 211 patients who completed the initial assessment, 144 completed the 7-day assessment, and of these, 112 stated that their CD-related health status had not changed significantly. The intraclass correlation coefficients for the 4 subscales were 0.88 to 0.94 (Table 2), indicating excellent reproducibility. The graphical method of Bland and Altman also revealed an excellent reproducibility throughout the range the F-CDQ total score (Figure 1) and the four subscales (not shown).

Bottom Line: Both the manifestations of the disease and the burden of the compulsory life-long gluten-free diet (GFD) have been shown to be associated with impairment of health-related quality of life.Reliability (intraclass correlation coefficients (ICC), Cronbach's alpha and Bland and Altman graphical analysis), validity (factorial structure and Rasch analysis, convergent validity), and responsiveness (effect size) of the F-CDQ were studied.Responsiveness was studied and effect sizes ≥ 0.20 were demonstrated for most of the subscales for patients who reported improvement or deterioration after 6 months.

View Article: PubMed Central - PubMed

Affiliation: Service de médecine interne, hôpital européen Georges Pompidou, Assistance Publiques - Hôpitaux de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; APEMAC, EA 4360, Université de Lorraine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

ABSTRACT

Background and objective: Celiac disease (CD) is a common chronic autoimmune disorder. Both the manifestations of the disease and the burden of the compulsory life-long gluten-free diet (GFD) have been shown to be associated with impairment of health-related quality of life. The objectives of this study were to provide a cross-cultural adaptation of the specific quality of life "Celiac Disease Questionnaire" (CDQ) and to analyze its psychometric properties.

Materials and methods: A cross-cultural French adaptation of the CDQ (F-CDQ) was obtained according to the revised international guidelines. The questionnaire was administered at baseline to 211 patients with biopsy proven CD followed-up in a single tertiary referral centre. The questionnaire was also administered after 7 days and 6 months. Reliability (intraclass correlation coefficients (ICC), Cronbach's alpha and Bland and Altman graphical analysis), validity (factorial structure and Rasch analysis, convergent validity), and responsiveness (effect size) of the F-CDQ were studied.

Results: The reliability of the F-CDQ was excellent with ICC and Cronbach's alpha coefficients being between 0.79 and 0.94 for the four subscales and the total score. The factorial structure and the Rasch analysis showed that the four dimensions of the original instrument were retained. Correlations with external measures (a generic measure of quality of life, an anxiety and depression instrument, a self-assessed disease severity, and clinical manifestations) were all in the expected direction confirming the validity of the instrument. Responsiveness was studied and effect sizes ≥ 0.20 were demonstrated for most of the subscales for patients who reported improvement or deterioration after 6 months.

Conclusion: The F-CDQ retains the psychometric properties of the original instrument and should be useful in cross-national surveys and to assess outcome in clinical trials involving patients with CD.

Show MeSH
Related in: MedlinePlus