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Diagnosis of Kikuchi-Fujimoto disease: a comparison between open biopsy and minimally invasive ultrasound-guided core biopsy.

Yu SC, Chen CN, Huang HI, Chen TC, Wang CP, Lou PJ, Ko JY, Hsiao TY, Yang TL - PLoS ONE (2014)

Bottom Line: Similar pathological presentations were found both in the specimens of USCB and OB.Sampling errors were found both in USCB and OB.OB can be applied only in the failed cases of USCB.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, National Taiwan University Hospital, Taiwan.

ABSTRACT
Kikuchi-Fujimoto disease (KFD) is a self-limited disease without any need of surgical treatments. Sampling of tissue is the only invasive procedure during the clinical course. However, the standard sampling procedure with accuracy, minimal invasiveness, and esthetic maintenance has not been established yet. In this study, a retrospective review of clinical utility and pathological presentations of the ultrasound-guided core biopsy (USCB) and the open biopsy (OB) in consecutive KFD patients. From 2010 to 2012, 34 consecutive patients were enrolled. USCB was performed in 11 patients, and OB was done in 26 patients. KFD was confirmed in 82% cases by USCB. Similar pathological presentations were found both in the specimens of USCB and OB. In the three patients who had received both USCB and OB, KFD was confirmed by USCB in one case, while two by OB. Sampling errors were found both in USCB and OB. For diagnosing KFD, USCB can serve as the first-line diagnostic tool. OB can be applied only in the failed cases of USCB.

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Related in: MedlinePlus

Variable pathological presentations of KFD were shown within one lymph node.The left panel is the scanning view of a bisected lymph node. (Scale bar: 1 mm). The high power view of areas b, c, and d were shown in the right panels (Scale bar: 200 µm). Area b showed nonspecific reactive lymphoid hyperplasia. Area c showed necrosis with karyorrhexis. Area d showed. histiocytic infiltration with karyorrhexis. It demonstrated the possibility of sampling bias if distinct sites of the lesion were harvested.
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pone-0095886-g003: Variable pathological presentations of KFD were shown within one lymph node.The left panel is the scanning view of a bisected lymph node. (Scale bar: 1 mm). The high power view of areas b, c, and d were shown in the right panels (Scale bar: 200 µm). Area b showed nonspecific reactive lymphoid hyperplasia. Area c showed necrosis with karyorrhexis. Area d showed. histiocytic infiltration with karyorrhexis. It demonstrated the possibility of sampling bias if distinct sites of the lesion were harvested.

Mentions: The heterogeneous presentations of specific KFD pathological characterization were noted either within the same lymph nodes or among different lymph nodes. These typical pathological finding of KFD was either widespread (9 cases, 35%), or limited in focal area (17 cases, 65%) (Fig 3). Among 11 patients with multiple lymph nodes, the morphological variation among lymph nodes was evident in 9 cases (82%) (Fig 4).


Diagnosis of Kikuchi-Fujimoto disease: a comparison between open biopsy and minimally invasive ultrasound-guided core biopsy.

Yu SC, Chen CN, Huang HI, Chen TC, Wang CP, Lou PJ, Ko JY, Hsiao TY, Yang TL - PLoS ONE (2014)

Variable pathological presentations of KFD were shown within one lymph node.The left panel is the scanning view of a bisected lymph node. (Scale bar: 1 mm). The high power view of areas b, c, and d were shown in the right panels (Scale bar: 200 µm). Area b showed nonspecific reactive lymphoid hyperplasia. Area c showed necrosis with karyorrhexis. Area d showed. histiocytic infiltration with karyorrhexis. It demonstrated the possibility of sampling bias if distinct sites of the lesion were harvested.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008434&req=5

pone-0095886-g003: Variable pathological presentations of KFD were shown within one lymph node.The left panel is the scanning view of a bisected lymph node. (Scale bar: 1 mm). The high power view of areas b, c, and d were shown in the right panels (Scale bar: 200 µm). Area b showed nonspecific reactive lymphoid hyperplasia. Area c showed necrosis with karyorrhexis. Area d showed. histiocytic infiltration with karyorrhexis. It demonstrated the possibility of sampling bias if distinct sites of the lesion were harvested.
Mentions: The heterogeneous presentations of specific KFD pathological characterization were noted either within the same lymph nodes or among different lymph nodes. These typical pathological finding of KFD was either widespread (9 cases, 35%), or limited in focal area (17 cases, 65%) (Fig 3). Among 11 patients with multiple lymph nodes, the morphological variation among lymph nodes was evident in 9 cases (82%) (Fig 4).

Bottom Line: Similar pathological presentations were found both in the specimens of USCB and OB.Sampling errors were found both in USCB and OB.OB can be applied only in the failed cases of USCB.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, National Taiwan University Hospital, Taiwan.

ABSTRACT
Kikuchi-Fujimoto disease (KFD) is a self-limited disease without any need of surgical treatments. Sampling of tissue is the only invasive procedure during the clinical course. However, the standard sampling procedure with accuracy, minimal invasiveness, and esthetic maintenance has not been established yet. In this study, a retrospective review of clinical utility and pathological presentations of the ultrasound-guided core biopsy (USCB) and the open biopsy (OB) in consecutive KFD patients. From 2010 to 2012, 34 consecutive patients were enrolled. USCB was performed in 11 patients, and OB was done in 26 patients. KFD was confirmed in 82% cases by USCB. Similar pathological presentations were found both in the specimens of USCB and OB. In the three patients who had received both USCB and OB, KFD was confirmed by USCB in one case, while two by OB. Sampling errors were found both in USCB and OB. For diagnosing KFD, USCB can serve as the first-line diagnostic tool. OB can be applied only in the failed cases of USCB.

Show MeSH
Related in: MedlinePlus