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Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: a case report with immunohistochemical and molecular study.

Tatangelo F, Cantile M, Pelella A, Losito NS, Scognamiglio G, Bianco F, Belli A, Botti G - Diagn Pathol (2014)

Bottom Line: Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors.Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern.In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pathology Division, Istituto Nazionale Tumori "Fondazione G Pascale"-IRCCS, Naples, Italy. monicantile@libero.it.

ABSTRACT

Unlabelled: Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.

Virtual slides: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3720959161096807.

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Real time PCR expression of NeuroD1: 1) pancreatic normal sample; 2) pancreatic tumor sample; 3) prostatic tumor sample; 4) GP sample. All reactions were performed in triplicate and data are expressed as mean of relative amount of mRNAs levels.
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Figure 4: Real time PCR expression of NeuroD1: 1) pancreatic normal sample; 2) pancreatic tumor sample; 3) prostatic tumor sample; 4) GP sample. All reactions were performed in triplicate and data are expressed as mean of relative amount of mRNAs levels.

Mentions: qRT PCR analysis showed NeuroD1 over-expression compared to other cancer samples used as controls (FigureĀ 4).


Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: a case report with immunohistochemical and molecular study.

Tatangelo F, Cantile M, Pelella A, Losito NS, Scognamiglio G, Bianco F, Belli A, Botti G - Diagn Pathol (2014)

Real time PCR expression of NeuroD1: 1) pancreatic normal sample; 2) pancreatic tumor sample; 3) prostatic tumor sample; 4) GP sample. All reactions were performed in triplicate and data are expressed as mean of relative amount of mRNAs levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4008328&req=5

Figure 4: Real time PCR expression of NeuroD1: 1) pancreatic normal sample; 2) pancreatic tumor sample; 3) prostatic tumor sample; 4) GP sample. All reactions were performed in triplicate and data are expressed as mean of relative amount of mRNAs levels.
Mentions: qRT PCR analysis showed NeuroD1 over-expression compared to other cancer samples used as controls (FigureĀ 4).

Bottom Line: Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors.Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern.In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pathology Division, Istituto Nazionale Tumori "Fondazione G Pascale"-IRCCS, Naples, Italy. monicantile@libero.it.

ABSTRACT

Unlabelled: Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.

Virtual slides: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3720959161096807.

Show MeSH
Related in: MedlinePlus