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Comparative scanning electron microscopy of bullous diseases.

Almeida HL, Rossi G, Karam OR, Rocha NM, Silva RM - An Bras Dermatol (2014 Mar-Apr)

Bottom Line: The purpose of this study is to compare scanning electron microscopy findings of the blister roof in three distinct bullous diseases: one intraepidermal acantholytic (pemphigus foliaceus); one due to hemidesmosomal dysfunction (bullous pemphigoid); and one secondary to anchoring fibril dysfunction - type VII collagen (dystrophic epidermolysis bullosa).In bullous pemphigoid, the epidermis had a solid aspect.In dystrophic epidermolysis bullosa a net was seen in the blister roof.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal de Pelotas, Pelotas, RS, Brazil.

ABSTRACT
The purpose of this study is to compare scanning electron microscopy findings of the blister roof in three distinct bullous diseases: one intraepidermal acantholytic (pemphigus foliaceus); one due to hemidesmosomal dysfunction (bullous pemphigoid); and one secondary to anchoring fibril dysfunction - type VII collagen (dystrophic epidermolysis bullosa). In pemphigus foliaceus, acantholytic phenomena were readily demonstrated. In bullous pemphigoid, the epidermis had a solid aspect. In dystrophic epidermolysis bullosa a net was seen in the blister roof.

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SEM of a pemphigus foliaceus blister roof. a) acantholytickeratinocytes (original magnification x1,000) with irregular contour.b) detail of an acantholytic cell (original magnificationx3,000)
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f03: SEM of a pemphigus foliaceus blister roof. a) acantholytickeratinocytes (original magnification x1,000) with irregular contour.b) detail of an acantholytic cell (original magnificationx3,000)

Mentions: Pemphigus Foliaceus - under low magnification, in the inverted roof of thePF blister, it was observed that the keratinocytes lost intercellular contact, becomingpolygonal; demonstrating acantholytic phenomena, some keratinocytes became rounded,resembling the classic appearance of acantholytic cells under light microscopy (Figures 2 and 3).


Comparative scanning electron microscopy of bullous diseases.

Almeida HL, Rossi G, Karam OR, Rocha NM, Silva RM - An Bras Dermatol (2014 Mar-Apr)

SEM of a pemphigus foliaceus blister roof. a) acantholytickeratinocytes (original magnification x1,000) with irregular contour.b) detail of an acantholytic cell (original magnificationx3,000)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008074&req=5

f03: SEM of a pemphigus foliaceus blister roof. a) acantholytickeratinocytes (original magnification x1,000) with irregular contour.b) detail of an acantholytic cell (original magnificationx3,000)
Mentions: Pemphigus Foliaceus - under low magnification, in the inverted roof of thePF blister, it was observed that the keratinocytes lost intercellular contact, becomingpolygonal; demonstrating acantholytic phenomena, some keratinocytes became rounded,resembling the classic appearance of acantholytic cells under light microscopy (Figures 2 and 3).

Bottom Line: The purpose of this study is to compare scanning electron microscopy findings of the blister roof in three distinct bullous diseases: one intraepidermal acantholytic (pemphigus foliaceus); one due to hemidesmosomal dysfunction (bullous pemphigoid); and one secondary to anchoring fibril dysfunction - type VII collagen (dystrophic epidermolysis bullosa).In bullous pemphigoid, the epidermis had a solid aspect.In dystrophic epidermolysis bullosa a net was seen in the blister roof.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal de Pelotas, Pelotas, RS, Brazil.

ABSTRACT
The purpose of this study is to compare scanning electron microscopy findings of the blister roof in three distinct bullous diseases: one intraepidermal acantholytic (pemphigus foliaceus); one due to hemidesmosomal dysfunction (bullous pemphigoid); and one secondary to anchoring fibril dysfunction - type VII collagen (dystrophic epidermolysis bullosa). In pemphigus foliaceus, acantholytic phenomena were readily demonstrated. In bullous pemphigoid, the epidermis had a solid aspect. In dystrophic epidermolysis bullosa a net was seen in the blister roof.

Show MeSH
Related in: MedlinePlus