Limits...
Alopecia universalis during treatment with leflunomide and adalimumab - case report.

Lazzarini R, Capareli GC, Buense R, Lellis RF - An Bras Dermatol (2014 Mar-Apr)

Bottom Line: Its etiology is unknown, but immunological factors are implicated in its pathogenesis.With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described.We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

View Article: PubMed Central - PubMed

Affiliation: Santa Casa de São Paulo, São Paulo, SP, Brazil.

ABSTRACT
Alopecia areata is a non-scarring form of alopecia that can be localized or widespread. Its etiology is unknown, but immunological factors are implicated in its pathogenesis. With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described. We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

Show MeSH

Related in: MedlinePlus

Dermoscopy of scalp: black dots (yellow arrow) characterizing dystrophic hair andyellow dots (red rectangle), demonstrating activity of the disease
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4008065&req=5

f03: Dermoscopy of scalp: black dots (yellow arrow) characterizing dystrophic hair andyellow dots (red rectangle), demonstrating activity of the disease

Mentions: Dermoscopy of the scalp demonstrated presence of dystrophic hair and black dots, withsome yellowish spots (Figure 3). A diagnostichypothesis of AU triggered by usage of anti-TNF drug (adalimumab) and/or leflunomide wasmade and a biopsy of scalp was performed. The latest revealed presence of follicles withsuperficial, miniaturized hairs involved by a peribulbar perifollicular lymphocyticinflammatory infiltrate (Figure 4).


Alopecia universalis during treatment with leflunomide and adalimumab - case report.

Lazzarini R, Capareli GC, Buense R, Lellis RF - An Bras Dermatol (2014 Mar-Apr)

Dermoscopy of scalp: black dots (yellow arrow) characterizing dystrophic hair andyellow dots (red rectangle), demonstrating activity of the disease
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008065&req=5

f03: Dermoscopy of scalp: black dots (yellow arrow) characterizing dystrophic hair andyellow dots (red rectangle), demonstrating activity of the disease
Mentions: Dermoscopy of the scalp demonstrated presence of dystrophic hair and black dots, withsome yellowish spots (Figure 3). A diagnostichypothesis of AU triggered by usage of anti-TNF drug (adalimumab) and/or leflunomide wasmade and a biopsy of scalp was performed. The latest revealed presence of follicles withsuperficial, miniaturized hairs involved by a peribulbar perifollicular lymphocyticinflammatory infiltrate (Figure 4).

Bottom Line: Its etiology is unknown, but immunological factors are implicated in its pathogenesis.With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described.We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

View Article: PubMed Central - PubMed

Affiliation: Santa Casa de São Paulo, São Paulo, SP, Brazil.

ABSTRACT
Alopecia areata is a non-scarring form of alopecia that can be localized or widespread. Its etiology is unknown, but immunological factors are implicated in its pathogenesis. With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described. We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

Show MeSH
Related in: MedlinePlus