Limits...
Alopecia universalis during treatment with leflunomide and adalimumab - case report.

Lazzarini R, Capareli GC, Buense R, Lellis RF - An Bras Dermatol (2014 Mar-Apr)

Bottom Line: Its etiology is unknown, but immunological factors are implicated in its pathogenesis.With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described.We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

View Article: PubMed Central - PubMed

Affiliation: Santa Casa de São Paulo, São Paulo, SP, Brazil.

ABSTRACT
Alopecia areata is a non-scarring form of alopecia that can be localized or widespread. Its etiology is unknown, but immunological factors are implicated in its pathogenesis. With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described. We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

Show MeSH

Related in: MedlinePlus

Cupuliform depressions on fingernails and some linear hemorrhages
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4008065&req=5

f02: Cupuliform depressions on fingernails and some linear hemorrhages

Mentions: Female patient, 66 years old, with a history of rheumatoid arthritis and hypothyroidism,was referred to our clinic by the rheumatologist, with complaint of loss of all bodyhair and alterations in her fingernails for the past six months. She denied havingsimilar symptoms before. She had been using Adalimumab and Leflunomide for one year dueto rheumatoid arthritis (RA), but as a result of alterations in hair and nails, herrheumatologist modified the therapeutic scheme, replacing adalimumab by etanercept andsuspending leflunomide, with no clinical picture alteration, and then referred her toour clinic. During the dermatological exam she presented nonscarring alopecia ofuniversal distribution, with presence of few hairs, thin and pigmented, around 3 cmlong, on the scalp (Figure 1). All hand nailspresented dystrophy with presence of cupuliform depressions (pitting) (Figure 2).


Alopecia universalis during treatment with leflunomide and adalimumab - case report.

Lazzarini R, Capareli GC, Buense R, Lellis RF - An Bras Dermatol (2014 Mar-Apr)

Cupuliform depressions on fingernails and some linear hemorrhages
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008065&req=5

f02: Cupuliform depressions on fingernails and some linear hemorrhages
Mentions: Female patient, 66 years old, with a history of rheumatoid arthritis and hypothyroidism,was referred to our clinic by the rheumatologist, with complaint of loss of all bodyhair and alterations in her fingernails for the past six months. She denied havingsimilar symptoms before. She had been using Adalimumab and Leflunomide for one year dueto rheumatoid arthritis (RA), but as a result of alterations in hair and nails, herrheumatologist modified the therapeutic scheme, replacing adalimumab by etanercept andsuspending leflunomide, with no clinical picture alteration, and then referred her toour clinic. During the dermatological exam she presented nonscarring alopecia ofuniversal distribution, with presence of few hairs, thin and pigmented, around 3 cmlong, on the scalp (Figure 1). All hand nailspresented dystrophy with presence of cupuliform depressions (pitting) (Figure 2).

Bottom Line: Its etiology is unknown, but immunological factors are implicated in its pathogenesis.With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described.We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

View Article: PubMed Central - PubMed

Affiliation: Santa Casa de São Paulo, São Paulo, SP, Brazil.

ABSTRACT
Alopecia areata is a non-scarring form of alopecia that can be localized or widespread. Its etiology is unknown, but immunological factors are implicated in its pathogenesis. With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described. We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.

Show MeSH
Related in: MedlinePlus