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Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions.

Carneiro FR, Amaral GB, Mendes MD, Quaresma JA - An Bras Dermatol (2014 Mar-Apr)

Bottom Line: However, its etiology remains uncertain.The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis.The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them.

View Article: PubMed Central - PubMed

Affiliation: Universidade do Estado do Pará, Belém, PA, Brazil.

ABSTRACT

Background: Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain.

Objective: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba.

Method: Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis.

Results: The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity.

Conclusion: We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease.

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Mean and standard deviation cell count per field in patients with atopicdermatitis and pityriasis alba
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f02: Mean and standard deviation cell count per field in patients with atopicdermatitis and pityriasis alba

Mentions: In order to determine tissue immunostaining for factor XIIIa in dermal dendrocytes ofskin lesions of PA and AD we used descriptive and inferential statistics. Quantitativevariables were expressed as measures of central tendency and variation. The statisticalinference for the quantitative variables was performed using Student's t test (Ayres etal, 2007, p.126) because the assumptions of homoscedasticity and normality weresatisfied, according to the Shapiro-Wilk test (Ayres et al, 2007, p.206) (Figure 2). The cutoff point and the ROC curve(Receiver Operating Characteristic Curve) were calculated (Figure 3).18 Thealpha level to reject the hypothesis was set 0.05. The statistical analysis wasperformed using the computer program BioEstat version 5.2.


Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions.

Carneiro FR, Amaral GB, Mendes MD, Quaresma JA - An Bras Dermatol (2014 Mar-Apr)

Mean and standard deviation cell count per field in patients with atopicdermatitis and pityriasis alba
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008054&req=5

f02: Mean and standard deviation cell count per field in patients with atopicdermatitis and pityriasis alba
Mentions: In order to determine tissue immunostaining for factor XIIIa in dermal dendrocytes ofskin lesions of PA and AD we used descriptive and inferential statistics. Quantitativevariables were expressed as measures of central tendency and variation. The statisticalinference for the quantitative variables was performed using Student's t test (Ayres etal, 2007, p.126) because the assumptions of homoscedasticity and normality weresatisfied, according to the Shapiro-Wilk test (Ayres et al, 2007, p.206) (Figure 2). The cutoff point and the ROC curve(Receiver Operating Characteristic Curve) were calculated (Figure 3).18 Thealpha level to reject the hypothesis was set 0.05. The statistical analysis wasperformed using the computer program BioEstat version 5.2.

Bottom Line: However, its etiology remains uncertain.The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis.The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them.

View Article: PubMed Central - PubMed

Affiliation: Universidade do Estado do Pará, Belém, PA, Brazil.

ABSTRACT

Background: Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain.

Objective: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba.

Method: Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis.

Results: The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity.

Conclusion: We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease.

Show MeSH
Related in: MedlinePlus