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Response of the adrenergic system after provoked bronchoconstriction in patients with bronchial asthma.

Islami H, Ilazi A, Gashi N, Mustafa L, Maloku H, Jashanica A - Acta Inform Med (2014)

Bottom Line: Two hours after the inhalation of Propranolol, in experimental group, it was applied the blocker of alpha-2 adrenergic receptors (Tolazoline 20 mg / ml with inhalator ways), which did not cause changes in bronchomotor tonus of tracheobronchial system (p > 1.0).Meanwhile, at the same patient, stimulation of beta-2 adrenergic receptor with Hexoprenaline (2 inh x 0.2 mg) is associated with a significant decrease of the specific resistance of airways (SRaw, p < 0.01).Furthermore, two hours after acetylcholine-aerosol (1 mg /ml) was applied, inhaled Ipratropium (2 inh x 1 mg) has fully blocked the action of chemical bronchoconstrictor mediators, causing a decline of specific resistance in the airways (SRaw; p < 0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.

ABSTRACT

Objective: In this paper, effect of the Tolazoline as antagonist of the alpha-2 adrenergic receptors in patients with bronchial asthma and chronic obstructive bronchitis was studied, and also the effect of stimulation with Hexoprenaline of beta-2 adrenergic receptor after bronchi-constriction caused with Propranolol, and Acetylcholine.

Methods: Lung function parameters are determined with Body plethysmography. In patients with bronchial asthma and chronic obstructive bronchitis was registered resistance (Raw), was determined the amount of intrathoracic gas volume (ITGV), and specific resistance was calculated as well (SRaw). Aerosolization was done with standard aerosolizing machine-Asema.

Results: The study included a total of 21 patients. Two hours after the inhalation of Propranolol, in experimental group, it was applied the blocker of alpha-2 adrenergic receptors (Tolazoline 20 mg / ml with inhalator ways), which did not cause changes in bronchomotor tonus of tracheobronchial system (p > 1.0). Meanwhile, at the same patient, stimulation of beta-2 adrenergic receptor with Hexoprenaline (2 inh x 0.2 mg) is associated with a significant decrease of the specific resistance of airways (SRaw, p < 0.01). Control group results show that after bronchi-constriction caused by Propranolol-aerosol (20 mg / ml) in patients with bronchial asthma and chronic obstructive bronchitis, an increase of specific resistance in airways was caused (SRaw, p < 0.01), which confirms the presence of hyper-reactive bronco-constrictor effects intermediated by vagal ways. Two hours after Propranolol, inhaled Hexorenaline has blocked the action of Propranolol, but not entirely. Furthermore, two hours after acetylcholine-aerosol (1 mg /ml) was applied, inhaled Ipratropium (2 inh x 1 mg) has fully blocked the action of chemical bronchoconstrictor mediators, causing a decline of specific resistance in the airways (SRaw; p < 0.01).

Conclusion: This suggests that primary mechanism, which would cause reaction in patients with increased bronchial reactibility, is prevalence of the cholinergic system over adrenergic one, and not the relationship in between alpha-2 and beta-2 adrenergic receptors.

No MeSH data available.


Related in: MedlinePlus

Protective action of Hexoprenaline (2 inh. x 0.2 mg) in the bronchoconstriction caused by Propranolol – aerosol (20 mg/ml). (X±SEM).
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Figure 3: Protective action of Hexoprenaline (2 inh. x 0.2 mg) in the bronchoconstriction caused by Propranolol – aerosol (20 mg/ml). (X±SEM).

Mentions: Results of this research, in diseased with bronchial asthma and with chronic obstructive bronchitis, shows that blockage of alpha-2 adrenergic receptor with Tolazoline (20 mg with inhalator ways) does not change in a significant manner (p > 0.1) the bronchomotor tonus of the tracheobronchial system, in comparison to Hexoprenaline (beta-2 adrenergic agonist) and Ipratropium bromide (anticholinergic), which are very effective in the removal of the increased bronchomotor tonus, by causing decrease of the resistance (Raw), respectively specific resistance (SRaw), after provocation with Propranolol and Acetylcholine. Gained data with this research shows a statistical significance (p < 0.01). See fig. 2, 3 and 4.


Response of the adrenergic system after provoked bronchoconstriction in patients with bronchial asthma.

Islami H, Ilazi A, Gashi N, Mustafa L, Maloku H, Jashanica A - Acta Inform Med (2014)

Protective action of Hexoprenaline (2 inh. x 0.2 mg) in the bronchoconstriction caused by Propranolol – aerosol (20 mg/ml). (X±SEM).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008033&req=5

Figure 3: Protective action of Hexoprenaline (2 inh. x 0.2 mg) in the bronchoconstriction caused by Propranolol – aerosol (20 mg/ml). (X±SEM).
Mentions: Results of this research, in diseased with bronchial asthma and with chronic obstructive bronchitis, shows that blockage of alpha-2 adrenergic receptor with Tolazoline (20 mg with inhalator ways) does not change in a significant manner (p > 0.1) the bronchomotor tonus of the tracheobronchial system, in comparison to Hexoprenaline (beta-2 adrenergic agonist) and Ipratropium bromide (anticholinergic), which are very effective in the removal of the increased bronchomotor tonus, by causing decrease of the resistance (Raw), respectively specific resistance (SRaw), after provocation with Propranolol and Acetylcholine. Gained data with this research shows a statistical significance (p < 0.01). See fig. 2, 3 and 4.

Bottom Line: Two hours after the inhalation of Propranolol, in experimental group, it was applied the blocker of alpha-2 adrenergic receptors (Tolazoline 20 mg / ml with inhalator ways), which did not cause changes in bronchomotor tonus of tracheobronchial system (p > 1.0).Meanwhile, at the same patient, stimulation of beta-2 adrenergic receptor with Hexoprenaline (2 inh x 0.2 mg) is associated with a significant decrease of the specific resistance of airways (SRaw, p < 0.01).Furthermore, two hours after acetylcholine-aerosol (1 mg /ml) was applied, inhaled Ipratropium (2 inh x 1 mg) has fully blocked the action of chemical bronchoconstrictor mediators, causing a decline of specific resistance in the airways (SRaw; p < 0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.

ABSTRACT

Objective: In this paper, effect of the Tolazoline as antagonist of the alpha-2 adrenergic receptors in patients with bronchial asthma and chronic obstructive bronchitis was studied, and also the effect of stimulation with Hexoprenaline of beta-2 adrenergic receptor after bronchi-constriction caused with Propranolol, and Acetylcholine.

Methods: Lung function parameters are determined with Body plethysmography. In patients with bronchial asthma and chronic obstructive bronchitis was registered resistance (Raw), was determined the amount of intrathoracic gas volume (ITGV), and specific resistance was calculated as well (SRaw). Aerosolization was done with standard aerosolizing machine-Asema.

Results: The study included a total of 21 patients. Two hours after the inhalation of Propranolol, in experimental group, it was applied the blocker of alpha-2 adrenergic receptors (Tolazoline 20 mg / ml with inhalator ways), which did not cause changes in bronchomotor tonus of tracheobronchial system (p > 1.0). Meanwhile, at the same patient, stimulation of beta-2 adrenergic receptor with Hexoprenaline (2 inh x 0.2 mg) is associated with a significant decrease of the specific resistance of airways (SRaw, p < 0.01). Control group results show that after bronchi-constriction caused by Propranolol-aerosol (20 mg / ml) in patients with bronchial asthma and chronic obstructive bronchitis, an increase of specific resistance in airways was caused (SRaw, p < 0.01), which confirms the presence of hyper-reactive bronco-constrictor effects intermediated by vagal ways. Two hours after Propranolol, inhaled Hexorenaline has blocked the action of Propranolol, but not entirely. Furthermore, two hours after acetylcholine-aerosol (1 mg /ml) was applied, inhaled Ipratropium (2 inh x 1 mg) has fully blocked the action of chemical bronchoconstrictor mediators, causing a decline of specific resistance in the airways (SRaw; p < 0.01).

Conclusion: This suggests that primary mechanism, which would cause reaction in patients with increased bronchial reactibility, is prevalence of the cholinergic system over adrenergic one, and not the relationship in between alpha-2 and beta-2 adrenergic receptors.

No MeSH data available.


Related in: MedlinePlus