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An experimental comparison of two different technetium source activities which can imitate thyroid scintigraphy in case of thyroid toxic nodule.

Miftari R, Fejza F, Bicaj X, Nura A, Topciu V, Bajrami I - Acta Inform Med (2014)

Bottom Line: In the second study were compared the sources with low activity in proportion 70:1(source A = 1.5 mCi and source B=0.021mCi).As clinical studies we preferred two different patents with different thyroid disorders.Also we found that covering of toxic nodules with lead cover (plaque), can allow visualization of activity in suppressed lobe.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, University Clinical Centre of Kosova, Prishtina, Kosova.

ABSTRACT

Purpose: In cases of thyroid toxic autonomous nodule, anterior projection of Tc-99m pertechnetate image shows a hot nodule that occupies most, or the entire thyroid lobe with near-total or total suppression of the contra lateral lobe. In this case is very difficult to distinguish toxic nodule from lobe agenesis. Our interest was to estimate and determinate the rate of radioactivity when the source with high activity can make total suppression of the second source with low activity in same conditions with thyroid scintigraphy procedures.

Material and methodology: Thyroid scintigraphy was performed with Technetium 99 meta stable pertechnetate. A parallel high resolution low energy collimator was used as an energy setting of 140 KeV photo peak for T-99m. Images are acquired at 200 Kilo Counts in the anterior projection with the collimator positioned as close as the patient's extended neck (approximately in distance of 18 cm). The scintigraphy of thyroid gland was performed 15 minutes after intravenous administration of 1.5 mCi Tc-99m pertechnetate. Technetium 99 meta stable radioactive sources with different activity were used for two scintigraphies studies, performed in same thyroid scintigraphy acquisition procedures. In the first study, were compared the standard source with high activity A=11.2 mCi with sources with variable activities B=1.33 mCi; 1.03 mCi; 0.7 mCi; 0.36 mCi; and 0.16mCi) in distance of 1.5cm from each other sources, which is approximately same with distance between two thyroid lobes. In the second study were compared the sources with low activity in proportion 70:1(source A = 1.5 mCi and source B=0.021mCi). As clinical studies we preferred two different patents with different thyroid disorders. There were one patient with thyroid toxic nodule in the right lobe, therefore the second patient was with left thyroid nodule agenesis.

Results: During our examination, we accurately determined that two radioactive sources in proportion 70:1 will be displayed as only one source with complete suppression of other source with low radioactivity. Also we found that covering of toxic nodules with lead cover (plaque), can allow visualization of activity in suppressed lobe.

Conclusion: Our study concluded that total lobe suppression, in cases of patients with thyroid toxic nodule, will happened for sure, if toxic nodule had accumulated seventy times more radioactivity than normal lobe. Also we concluded that covering of the toxic nodule with lead plaque, may permit the presentation of radioactivity in suppressed nodule.

No MeSH data available.


Related in: MedlinePlus

Coverage hot nodule
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Figure 4: Coverage hot nodule

Mentions: The scintigraphy of thyroid gland at first case showed a huge solitary toxic nodule in the right thyroid lobe at the lady patient 34 year old, while uptake in the normal left lobe was suppressed. In differential diagnosis were considered toxic adenoma or absence of the left lobule. As replacement test for the TSH test we have cover the right thyroid lobe with cover of lead and then on the display was registered accumulation on the left thyroid suppressed lobe (figure 3, 4)


An experimental comparison of two different technetium source activities which can imitate thyroid scintigraphy in case of thyroid toxic nodule.

Miftari R, Fejza F, Bicaj X, Nura A, Topciu V, Bajrami I - Acta Inform Med (2014)

Coverage hot nodule
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4008031&req=5

Figure 4: Coverage hot nodule
Mentions: The scintigraphy of thyroid gland at first case showed a huge solitary toxic nodule in the right thyroid lobe at the lady patient 34 year old, while uptake in the normal left lobe was suppressed. In differential diagnosis were considered toxic adenoma or absence of the left lobule. As replacement test for the TSH test we have cover the right thyroid lobe with cover of lead and then on the display was registered accumulation on the left thyroid suppressed lobe (figure 3, 4)

Bottom Line: In the second study were compared the sources with low activity in proportion 70:1(source A = 1.5 mCi and source B=0.021mCi).As clinical studies we preferred two different patents with different thyroid disorders.Also we found that covering of toxic nodules with lead cover (plaque), can allow visualization of activity in suppressed lobe.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, University Clinical Centre of Kosova, Prishtina, Kosova.

ABSTRACT

Purpose: In cases of thyroid toxic autonomous nodule, anterior projection of Tc-99m pertechnetate image shows a hot nodule that occupies most, or the entire thyroid lobe with near-total or total suppression of the contra lateral lobe. In this case is very difficult to distinguish toxic nodule from lobe agenesis. Our interest was to estimate and determinate the rate of radioactivity when the source with high activity can make total suppression of the second source with low activity in same conditions with thyroid scintigraphy procedures.

Material and methodology: Thyroid scintigraphy was performed with Technetium 99 meta stable pertechnetate. A parallel high resolution low energy collimator was used as an energy setting of 140 KeV photo peak for T-99m. Images are acquired at 200 Kilo Counts in the anterior projection with the collimator positioned as close as the patient's extended neck (approximately in distance of 18 cm). The scintigraphy of thyroid gland was performed 15 minutes after intravenous administration of 1.5 mCi Tc-99m pertechnetate. Technetium 99 meta stable radioactive sources with different activity were used for two scintigraphies studies, performed in same thyroid scintigraphy acquisition procedures. In the first study, were compared the standard source with high activity A=11.2 mCi with sources with variable activities B=1.33 mCi; 1.03 mCi; 0.7 mCi; 0.36 mCi; and 0.16mCi) in distance of 1.5cm from each other sources, which is approximately same with distance between two thyroid lobes. In the second study were compared the sources with low activity in proportion 70:1(source A = 1.5 mCi and source B=0.021mCi). As clinical studies we preferred two different patents with different thyroid disorders. There were one patient with thyroid toxic nodule in the right lobe, therefore the second patient was with left thyroid nodule agenesis.

Results: During our examination, we accurately determined that two radioactive sources in proportion 70:1 will be displayed as only one source with complete suppression of other source with low radioactivity. Also we found that covering of toxic nodules with lead cover (plaque), can allow visualization of activity in suppressed lobe.

Conclusion: Our study concluded that total lobe suppression, in cases of patients with thyroid toxic nodule, will happened for sure, if toxic nodule had accumulated seventy times more radioactivity than normal lobe. Also we concluded that covering of the toxic nodule with lead plaque, may permit the presentation of radioactivity in suppressed nodule.

No MeSH data available.


Related in: MedlinePlus