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Evaluation of nanodispersion of iron oxides using various polymers.

Tanaka Y, Ueyama H, Ogata M, Daikoku T, Morimoto M, Kitagawa A, Imajo Y, Tahara T, Inkyo M, Yamaguchi N, Nagata S - Indian J Pharm Sci (2014)

Bottom Line: In order to create Fe2O3 and Fe2O3·H2O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated.Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe2O3 nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill.The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.

ABSTRACT
In order to create Fe2O3 and Fe2O3·H2O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length of the polymers and the surface tension of the particles affected the dispersibility of Fe2O3 and Fe2O3·H2O particles. Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe2O3 nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill. Fe2O3·H2O nanoparticles could also be produced using 5.0% hydroxypropylcellulose-SSL and 4.0 and 7.0% Pharmacoat 904. The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill.

No MeSH data available.


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Mentions: In order to evaluate the effect of the molecular length of each polymer on the IFD values, the molecular lengths of HPC, HPMC and MC were calculated from each mean degree of polymerisation (DPw), using data provided by Nippon Soda Co., Ltd., and Shin-Etsu Chemical Co., Ltd., and the monomer molecular size of glucose by assuming that these polymers are straight chains (Table 1). The minimum energy of glucose was calculated by the molecular mechanics (MM2) program in Chem 3D® Pro ver. 8.0, and the glucose size from oxygen of 1C to 4C was estimated to be 0.42 nm. The relationships between the IFD values and the lengths are shown in figs. 2 and 3. The IFD values of Fe2O3 and Fe2O3·H2O evaluated from each polymer solution with almost the same viscosity (20.5-27.3 and 10.5-15.4 MPas for Fe2O3 and Fe2O3·H2O, respectively) were used to avoid the influence of viscosity on the relationships. In Fe2O3 (fig. 2a–c), the IFD in solution of HPC-SSL, Pharmacoat 645, Pharmacoat 606 and Pharmacoat 904, all of which have shorter lengths, showed high values ranging from 84.6 to 96.5. As the lengths increased, the IFD values tended to decrease, and the IFD value associated with 0.5% HPC-H with the longest length had the lowest IFD value (5.6). In case of Fe2O3·H2O (fig. 3a–c), the IFD values also decreased as the polymer lengths increased. The IFD values in solution of HPC-SSL and Pharmacoat 904 showed relatively high values of 78.9 and 75.5, respectively, whereas those of HPC-H, 60SH-4000, and 60SH-10000 were less than 1.


Evaluation of nanodispersion of iron oxides using various polymers.

Tanaka Y, Ueyama H, Ogata M, Daikoku T, Morimoto M, Kitagawa A, Imajo Y, Tahara T, Inkyo M, Yamaguchi N, Nagata S - Indian J Pharm Sci (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4007256&req=5

Mentions: In order to evaluate the effect of the molecular length of each polymer on the IFD values, the molecular lengths of HPC, HPMC and MC were calculated from each mean degree of polymerisation (DPw), using data provided by Nippon Soda Co., Ltd., and Shin-Etsu Chemical Co., Ltd., and the monomer molecular size of glucose by assuming that these polymers are straight chains (Table 1). The minimum energy of glucose was calculated by the molecular mechanics (MM2) program in Chem 3D® Pro ver. 8.0, and the glucose size from oxygen of 1C to 4C was estimated to be 0.42 nm. The relationships between the IFD values and the lengths are shown in figs. 2 and 3. The IFD values of Fe2O3 and Fe2O3·H2O evaluated from each polymer solution with almost the same viscosity (20.5-27.3 and 10.5-15.4 MPas for Fe2O3 and Fe2O3·H2O, respectively) were used to avoid the influence of viscosity on the relationships. In Fe2O3 (fig. 2a–c), the IFD in solution of HPC-SSL, Pharmacoat 645, Pharmacoat 606 and Pharmacoat 904, all of which have shorter lengths, showed high values ranging from 84.6 to 96.5. As the lengths increased, the IFD values tended to decrease, and the IFD value associated with 0.5% HPC-H with the longest length had the lowest IFD value (5.6). In case of Fe2O3·H2O (fig. 3a–c), the IFD values also decreased as the polymer lengths increased. The IFD values in solution of HPC-SSL and Pharmacoat 904 showed relatively high values of 78.9 and 75.5, respectively, whereas those of HPC-H, 60SH-4000, and 60SH-10000 were less than 1.

Bottom Line: In order to create Fe2O3 and Fe2O3·H2O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated.Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe2O3 nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill.The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 7370112, Japan.

ABSTRACT
In order to create Fe2O3 and Fe2O3·H2O nanoparticles, various polymers were used as dispersing agents, and the resulting effects on the dispersibility and nanoparticulation of the iron oxides were evaluated. It was revealed that not only the solution viscosity but also the molecular length of the polymers and the surface tension of the particles affected the dispersibility of Fe2O3 and Fe2O3·H2O particles. Using the dispersing agents 7.5% hydroxypropylcellulose-SSL, 6.0% Pharmacoat 603, 5.0% and 6.5% Pharmacoat 904 and 7.0% Metolose SM-4, Fe2O3 nanoparticles were successfully fabricated by wet milling using Ultra Apex Mill. Fe2O3·H2O nanoparticles could also be produced using 5.0% hydroxypropylcellulose-SSL and 4.0 and 7.0% Pharmacoat 904. The index for dispersibility developed in this study appears to be an effective indicator of success in fabricating nanoparticles of iron oxides by wet milling using Ultra Apex Mill.

No MeSH data available.


Related in: MedlinePlus