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Exercise Training and Grape Seed Extract Co-Administration Improves Lipid Profile, Weight Loss, Bradycardia, and Hypotension of STZ-Induced Diabetic Rats.

Badavi M, Abedi HA, Dianat M, Sarkaki AR - Int Cardiovasc Res J (2013)

Bottom Line: Co-administration of GSE and ET had more positive effects on lipid profile compared to each method alone.On the other hand, administration of ET or GSE alone did not affect systolic blood pressure and body weight, while their combination restored systolic blood pressure completely and improved body weight partially.This may constitute a convenient and inexpensive therapeutic approach to diabetic complications.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center, Physiology Department, Faculty of Medicine, Ahwaz Jundishapour University of Medical Sciences, Ahwaz, IR Iran.

ABSTRACT

Background: Exercise Training (ET) and Grape Seed Extract (GSE) as an antioxidant have many positive effects on controlling diabetes mellitus and its complications.

Objectives: This study aimed to determine the effects of GSE alone or combined with ET on body weight, plasma lipid profile, blood pressure, and heart rate in STZ-induced diabetic rats.

Methods: IN THIS STUDY, MALE WISTAR RATS WERE RANDOMLY ASSIGNED TO FIVE GROUPS: sedentary control, sedentary diabetic, trained diabetic, GSE treated sedentary diabetic, and GSE treated trained diabetic. ET was conducted on the treadmill daily for 8 weeks. One way ANOVA followed by LSD test was used for statistical analysis.

Results: Reduction of body weight, high density lipoproteins, heart rate, and systolic blood pressure and increment of total cholesterol, triglyceride, low density lipoprotein, and very low density lipoproteins were observed after STZ injection. Co-administration of GSE and ET had more positive effects on lipid profile compared to each method alone. In addition, GSE and ET modified heart rate partially, while their combination was more effective in improvement of heart rat in conscious rats. On the other hand, administration of ET or GSE alone did not affect systolic blood pressure and body weight, while their combination restored systolic blood pressure completely and improved body weight partially.

Conclusions: The study findings indicated that ET combined with GSE had more beneficial effects compared to each one alone on the complications of STZ induced diabetes. This may constitute a convenient and inexpensive therapeutic approach to diabetic complications.

No MeSH data available.


Related in: MedlinePlus

Weekly Body Weight Changes (Mean  ± SEM, n = 7 - 8) in Different Groups During 8 WeeksAbbreviations: SC, sedentary control; SD, sedentary diabetic; TrD, trained diabetic; ExD, GSE treated sedentary diabetic; TrExD, GSE treated trained diabetic*P < 0.05 significantly different from SC, † P < 0.05 significantly different from SD (repeated measurement ANOVA followed by LSD multiple comparison tests)
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fig8181: Weekly Body Weight Changes (Mean  ± SEM, n = 7 - 8) in Different Groups During 8 WeeksAbbreviations: SC, sedentary control; SD, sedentary diabetic; TrD, trained diabetic; ExD, GSE treated sedentary diabetic; TrExD, GSE treated trained diabetic*P < 0.05 significantly different from SC, † P < 0.05 significantly different from SD (repeated measurement ANOVA followed by LSD multiple comparison tests)

Mentions: At the beginning of the experiment, no significant difference was found among the study groups regarding their body weight (Figure 1). However, the control groups gained weight throughout 9 weeks. On the other hand, the body weight of the sedentary diabetic group reduced during the first 2 weeks after STZ injection. In trained diabetic and GSE treated sedentary diabetic groups also, this reduction continued for 3 weeks and then increased slightly to reach the pre-STZ values at week 8. Nevertheless, the body weight of the GSE + ET treated diabetic group reduced initially during the first 2 weeks after STZ injection, then began to increase throughout the next 7 weeks, and reached a value that was significantly different from the pre-STZ value (P < 0.001) as well as from the control group (Figure 1).


Exercise Training and Grape Seed Extract Co-Administration Improves Lipid Profile, Weight Loss, Bradycardia, and Hypotension of STZ-Induced Diabetic Rats.

Badavi M, Abedi HA, Dianat M, Sarkaki AR - Int Cardiovasc Res J (2013)

Weekly Body Weight Changes (Mean  ± SEM, n = 7 - 8) in Different Groups During 8 WeeksAbbreviations: SC, sedentary control; SD, sedentary diabetic; TrD, trained diabetic; ExD, GSE treated sedentary diabetic; TrExD, GSE treated trained diabetic*P < 0.05 significantly different from SC, † P < 0.05 significantly different from SD (repeated measurement ANOVA followed by LSD multiple comparison tests)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987445&req=5

fig8181: Weekly Body Weight Changes (Mean  ± SEM, n = 7 - 8) in Different Groups During 8 WeeksAbbreviations: SC, sedentary control; SD, sedentary diabetic; TrD, trained diabetic; ExD, GSE treated sedentary diabetic; TrExD, GSE treated trained diabetic*P < 0.05 significantly different from SC, † P < 0.05 significantly different from SD (repeated measurement ANOVA followed by LSD multiple comparison tests)
Mentions: At the beginning of the experiment, no significant difference was found among the study groups regarding their body weight (Figure 1). However, the control groups gained weight throughout 9 weeks. On the other hand, the body weight of the sedentary diabetic group reduced during the first 2 weeks after STZ injection. In trained diabetic and GSE treated sedentary diabetic groups also, this reduction continued for 3 weeks and then increased slightly to reach the pre-STZ values at week 8. Nevertheless, the body weight of the GSE + ET treated diabetic group reduced initially during the first 2 weeks after STZ injection, then began to increase throughout the next 7 weeks, and reached a value that was significantly different from the pre-STZ value (P < 0.001) as well as from the control group (Figure 1).

Bottom Line: Co-administration of GSE and ET had more positive effects on lipid profile compared to each method alone.On the other hand, administration of ET or GSE alone did not affect systolic blood pressure and body weight, while their combination restored systolic blood pressure completely and improved body weight partially.This may constitute a convenient and inexpensive therapeutic approach to diabetic complications.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center, Physiology Department, Faculty of Medicine, Ahwaz Jundishapour University of Medical Sciences, Ahwaz, IR Iran.

ABSTRACT

Background: Exercise Training (ET) and Grape Seed Extract (GSE) as an antioxidant have many positive effects on controlling diabetes mellitus and its complications.

Objectives: This study aimed to determine the effects of GSE alone or combined with ET on body weight, plasma lipid profile, blood pressure, and heart rate in STZ-induced diabetic rats.

Methods: IN THIS STUDY, MALE WISTAR RATS WERE RANDOMLY ASSIGNED TO FIVE GROUPS: sedentary control, sedentary diabetic, trained diabetic, GSE treated sedentary diabetic, and GSE treated trained diabetic. ET was conducted on the treadmill daily for 8 weeks. One way ANOVA followed by LSD test was used for statistical analysis.

Results: Reduction of body weight, high density lipoproteins, heart rate, and systolic blood pressure and increment of total cholesterol, triglyceride, low density lipoprotein, and very low density lipoproteins were observed after STZ injection. Co-administration of GSE and ET had more positive effects on lipid profile compared to each method alone. In addition, GSE and ET modified heart rate partially, while their combination was more effective in improvement of heart rat in conscious rats. On the other hand, administration of ET or GSE alone did not affect systolic blood pressure and body weight, while their combination restored systolic blood pressure completely and improved body weight partially.

Conclusions: The study findings indicated that ET combined with GSE had more beneficial effects compared to each one alone on the complications of STZ induced diabetes. This may constitute a convenient and inexpensive therapeutic approach to diabetic complications.

No MeSH data available.


Related in: MedlinePlus