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A Study on the Relationship between Serum Beta 2-Microglobulin Levels, Underlying Chronic Kidney Disease, and Peripheral Arterial Disease in High-Vascular-Risk Patients.

Real de Asúa D, Puchades R, García-Polo I, Suárez C - Int Cardiovasc Res J (2012)

Bottom Line: We found no correlation between B2M and ABI in our total population (r = -0.12) or in patients with PAD (r = -0.09; NS for both comparisons).We found no correlation between B2M levels and ABI values in high-vascular-risk patients that could usefully help in the subsequent diagnosis of PAD.However, we observed a significant correlation between B2M and eGFR, even when renal function was only slightly impaired.

View Article: PubMed Central - PubMed

Affiliation: Vascular Risk Unit, Internal Medicine Department, Fundación de Investigación Biomédica, Hospital Universitario La Princesa, Madrid, Spain.

ABSTRACT

Background: Serum beta 2-microglobulin (B2M) levels have been found to be increased in patients with peripheral arterial disease (PAD), yet it is still unknown whether B2M correlates with PAD intensity.

Objectives: We aim to evaluate the correlation between B2M and the ankle-brachial index (ABI) values in high-vascular-risk patients.

Methods: This is a cross-sectional study of 63 high-vascular-risk patients admitted to the Cardiology Department or evaluated as outpatients in the Internal Medicine Department of our institution. Patients were classified into two groups according to their ABI: patients without PAD (n = 44, ABI values between 0.9 and 1.4) and patients with PAD (n = 19, ABI values lower than 0.9 or higher than 1.4). We performed univariate and multivariate analysis based on a multiple linear regression model.

Results: Serum B2M levels were higher in patients with pathological ABI values than in those without PAD (2.36 ± 1.13 vs. 1.80 ± 0.65 mg/L; P<0.05). We found no correlation between B2M and ABI in our total population (r = -0.12) or in patients with PAD (r = -0.09; NS for both comparisons). Age, gender, arterial hypertension, estimated glomerular filtration rate (eGFR), uric acid, total cholesterol, and LDL-cholesterol correlated with B2M in the univariate analysis. In the final linear regression model, eGFR, uric acid and total cholesterol correlated independently with B2M (P<0.01).

Conclusion: We found no correlation between B2M levels and ABI values in high-vascular-risk patients that could usefully help in the subsequent diagnosis of PAD. However, we observed a significant correlation between B2M and eGFR, even when renal function was only slightly impaired.

No MeSH data available.


Related in: MedlinePlus

Correlation between Serum Beta 2-Microglobulin Levels and Ankle-Brachial Index in High-Vascular-Risk PatientsB2M, beta 2-microglobulin; ABI, ankle-brachial index.
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Related In: Results  -  Collection

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fig1379: Correlation between Serum Beta 2-Microglobulin Levels and Ankle-Brachial Index in High-Vascular-Risk PatientsB2M, beta 2-microglobulin; ABI, ankle-brachial index.

Mentions: The correlation between B2M and ABI was assessed in 55 patients. Eight subjects with outlying values of B2M were excluded from the analysis. No significant correlation between B2M and ABI values was found in our total population (Figure 1, r = –0.12; not significant), nor in patients with PAD (r = –0.09; not significant).


A Study on the Relationship between Serum Beta 2-Microglobulin Levels, Underlying Chronic Kidney Disease, and Peripheral Arterial Disease in High-Vascular-Risk Patients.

Real de Asúa D, Puchades R, García-Polo I, Suárez C - Int Cardiovasc Res J (2012)

Correlation between Serum Beta 2-Microglobulin Levels and Ankle-Brachial Index in High-Vascular-Risk PatientsB2M, beta 2-microglobulin; ABI, ankle-brachial index.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987415&req=5

fig1379: Correlation between Serum Beta 2-Microglobulin Levels and Ankle-Brachial Index in High-Vascular-Risk PatientsB2M, beta 2-microglobulin; ABI, ankle-brachial index.
Mentions: The correlation between B2M and ABI was assessed in 55 patients. Eight subjects with outlying values of B2M were excluded from the analysis. No significant correlation between B2M and ABI values was found in our total population (Figure 1, r = –0.12; not significant), nor in patients with PAD (r = –0.09; not significant).

Bottom Line: We found no correlation between B2M and ABI in our total population (r = -0.12) or in patients with PAD (r = -0.09; NS for both comparisons).We found no correlation between B2M levels and ABI values in high-vascular-risk patients that could usefully help in the subsequent diagnosis of PAD.However, we observed a significant correlation between B2M and eGFR, even when renal function was only slightly impaired.

View Article: PubMed Central - PubMed

Affiliation: Vascular Risk Unit, Internal Medicine Department, Fundación de Investigación Biomédica, Hospital Universitario La Princesa, Madrid, Spain.

ABSTRACT

Background: Serum beta 2-microglobulin (B2M) levels have been found to be increased in patients with peripheral arterial disease (PAD), yet it is still unknown whether B2M correlates with PAD intensity.

Objectives: We aim to evaluate the correlation between B2M and the ankle-brachial index (ABI) values in high-vascular-risk patients.

Methods: This is a cross-sectional study of 63 high-vascular-risk patients admitted to the Cardiology Department or evaluated as outpatients in the Internal Medicine Department of our institution. Patients were classified into two groups according to their ABI: patients without PAD (n = 44, ABI values between 0.9 and 1.4) and patients with PAD (n = 19, ABI values lower than 0.9 or higher than 1.4). We performed univariate and multivariate analysis based on a multiple linear regression model.

Results: Serum B2M levels were higher in patients with pathological ABI values than in those without PAD (2.36 ± 1.13 vs. 1.80 ± 0.65 mg/L; P<0.05). We found no correlation between B2M and ABI in our total population (r = -0.12) or in patients with PAD (r = -0.09; NS for both comparisons). Age, gender, arterial hypertension, estimated glomerular filtration rate (eGFR), uric acid, total cholesterol, and LDL-cholesterol correlated with B2M in the univariate analysis. In the final linear regression model, eGFR, uric acid and total cholesterol correlated independently with B2M (P<0.01).

Conclusion: We found no correlation between B2M levels and ABI values in high-vascular-risk patients that could usefully help in the subsequent diagnosis of PAD. However, we observed a significant correlation between B2M and eGFR, even when renal function was only slightly impaired.

No MeSH data available.


Related in: MedlinePlus