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Assessment of the relationship between non-alcoholic fatty liver disease and CAD using MSCT.

Efe D, Aygün F - Arq. Bras. Cardiol. (2013)

Bottom Line: The patients were divided into two groups according to the presence of NAFLD.NAFLD was determined according to the MSCT protocol, using the liver density.There were 50 (24.5%) non-obsCAD and 57 (27.9%) obsCAD cases in Group 1, and 39 (23.2%) non-obsCAD and 23 (13.7%) obsCAD cases in Group 2.

View Article: PubMed Central - PubMed

Affiliation: Mevlana University, Faculdade de Medicina, Departamento de Radiologia, Konya, Turquia.

ABSTRACT

Background: Some risk factors for atherosclerosis are followed by non-alcoholic fatty liver disease (NAFLD). We wanted to use Multislice computed tomography (MSCT) as technique for searching relationship between NAFLD and coronary artery disease (CAD).

Objective: The relationship between NAFLD and CAD was investigated using MSCT.

Methods: A total of 372 individuals with or without cardiac symptoms who had undergone MSCT angiography were included in the study. The patients were divided into two groups according to the presence of NAFLD. Coronary artery segments were visually evaluated via MSCT angiography. Based on the coronary artery stenosis degree, those with no or minimal plaques were considered normal, whereas those who had stenosis of less than 50% and at least one plaque were considered to have non-obstructive coronary artery disease (non-obsCAD). The patients who had at least one plaque and coronary artery stenosis of 50% or more were considered to have obstructive coronary artery disease (obsCAD). NAFLD was determined according to the MSCT protocol, using the liver density.

Results: According to the liver density, the number of patients with non-alcoholic fatty liver disease (group 1) was 204 (149 males, 54.8%) and with normal liver (group 2) was 168 (95 males, 45.2%). There were 50 (24.5%) non-obsCAD and 57 (27.9%) obsCAD cases in Group 1, and 39 (23.2%) non-obsCAD and 23 (13.7%) obsCAD cases in Group 2.

Conclusions: The present study using MSCT demonstrated that the frequency of coronary artery disease in patients with NAFDL was significantly higher than that of patients without NAFDL.

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Mean hepatic density according to ages
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f05: Mean hepatic density according to ages

Mentions: The mean liver density was 43 ± 9.1 HU (range 14-56) in males, and 45.5 ± 8.4 HU (range31-58) in females of Group 1. The corresponding figures were 61.8 ± 4.7 HU (range,56-75), and 62.6 ± 5.7 HU (range, 54-74) in the males and females of Group 2,respectively. Mean liver densities of the groups according to their ages aredemonstrated in Figure 5.


Assessment of the relationship between non-alcoholic fatty liver disease and CAD using MSCT.

Efe D, Aygün F - Arq. Bras. Cardiol. (2013)

Mean hepatic density according to ages
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987385&req=5

f05: Mean hepatic density according to ages
Mentions: The mean liver density was 43 ± 9.1 HU (range 14-56) in males, and 45.5 ± 8.4 HU (range31-58) in females of Group 1. The corresponding figures were 61.8 ± 4.7 HU (range,56-75), and 62.6 ± 5.7 HU (range, 54-74) in the males and females of Group 2,respectively. Mean liver densities of the groups according to their ages aredemonstrated in Figure 5.

Bottom Line: The patients were divided into two groups according to the presence of NAFLD.NAFLD was determined according to the MSCT protocol, using the liver density.There were 50 (24.5%) non-obsCAD and 57 (27.9%) obsCAD cases in Group 1, and 39 (23.2%) non-obsCAD and 23 (13.7%) obsCAD cases in Group 2.

View Article: PubMed Central - PubMed

Affiliation: Mevlana University, Faculdade de Medicina, Departamento de Radiologia, Konya, Turquia.

ABSTRACT

Background: Some risk factors for atherosclerosis are followed by non-alcoholic fatty liver disease (NAFLD). We wanted to use Multislice computed tomography (MSCT) as technique for searching relationship between NAFLD and coronary artery disease (CAD).

Objective: The relationship between NAFLD and CAD was investigated using MSCT.

Methods: A total of 372 individuals with or without cardiac symptoms who had undergone MSCT angiography were included in the study. The patients were divided into two groups according to the presence of NAFLD. Coronary artery segments were visually evaluated via MSCT angiography. Based on the coronary artery stenosis degree, those with no or minimal plaques were considered normal, whereas those who had stenosis of less than 50% and at least one plaque were considered to have non-obstructive coronary artery disease (non-obsCAD). The patients who had at least one plaque and coronary artery stenosis of 50% or more were considered to have obstructive coronary artery disease (obsCAD). NAFLD was determined according to the MSCT protocol, using the liver density.

Results: According to the liver density, the number of patients with non-alcoholic fatty liver disease (group 1) was 204 (149 males, 54.8%) and with normal liver (group 2) was 168 (95 males, 45.2%). There were 50 (24.5%) non-obsCAD and 57 (27.9%) obsCAD cases in Group 1, and 39 (23.2%) non-obsCAD and 23 (13.7%) obsCAD cases in Group 2.

Conclusions: The present study using MSCT demonstrated that the frequency of coronary artery disease in patients with NAFDL was significantly higher than that of patients without NAFDL.

Show MeSH
Related in: MedlinePlus