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Delayed diagnosis of an Ewing sarcoma of the knee during pregnancy.

Verheecke M, Salembier C, Vanderlinden S - Facts Views Vis Obgyn (2013)

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Europe Hospitals Brussels, Ukkel, Belgium.

No MeSH data available.


Related in: MedlinePlus

Double colour interphase FISH analysis of tumour specimens using break-apart EWS (A) and WT1 (B) DNA probes. The present of split apart green and red hybridization signals (A) indicate EWS rearrangement (marked with arrows). Conversely, WT1 gene was not rearranged as judged by juxtaposed red/green hybridization signals (B).
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Figure 4: Double colour interphase FISH analysis of tumour specimens using break-apart EWS (A) and WT1 (B) DNA probes. The present of split apart green and red hybridization signals (A) indicate EWS rearrangement (marked with arrows). Conversely, WT1 gene was not rearranged as judged by juxtaposed red/green hybridization signals (B).

Mentions: In view of these findings the differential diagnosis of a metastatic breast cancer or metastases of a primary bone tumour was withheld. The microscopic examination of a biopsy of one of the large breast nodules revealed the presence of a small blue round cell tumour, suggesting a primary bone tumour, which was confirmed by immunohistochemistry (CD99 expression) (Figure 3). Additional FISH analysis revealed rearrangement of the EWS gene, and not of the WT1 gene, indicating the diagnosis of Ewing sarcoma (Figure 4). Four days postpartum, chemotherapy was initiated. A 3-week alternating treatment of vincristine/adriamycin/cyclophosphamide (VAC) and etoposide/iphosphamide (IFO-VP16) was given, which was well tolerated apart from slight anaemia and constipation. After one cycle of chemotherapy the patient reported less pain and a reduction of the volume, redness and inflammation around the knee was observed.


Delayed diagnosis of an Ewing sarcoma of the knee during pregnancy.

Verheecke M, Salembier C, Vanderlinden S - Facts Views Vis Obgyn (2013)

Double colour interphase FISH analysis of tumour specimens using break-apart EWS (A) and WT1 (B) DNA probes. The present of split apart green and red hybridization signals (A) indicate EWS rearrangement (marked with arrows). Conversely, WT1 gene was not rearranged as judged by juxtaposed red/green hybridization signals (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987357&req=5

Figure 4: Double colour interphase FISH analysis of tumour specimens using break-apart EWS (A) and WT1 (B) DNA probes. The present of split apart green and red hybridization signals (A) indicate EWS rearrangement (marked with arrows). Conversely, WT1 gene was not rearranged as judged by juxtaposed red/green hybridization signals (B).
Mentions: In view of these findings the differential diagnosis of a metastatic breast cancer or metastases of a primary bone tumour was withheld. The microscopic examination of a biopsy of one of the large breast nodules revealed the presence of a small blue round cell tumour, suggesting a primary bone tumour, which was confirmed by immunohistochemistry (CD99 expression) (Figure 3). Additional FISH analysis revealed rearrangement of the EWS gene, and not of the WT1 gene, indicating the diagnosis of Ewing sarcoma (Figure 4). Four days postpartum, chemotherapy was initiated. A 3-week alternating treatment of vincristine/adriamycin/cyclophosphamide (VAC) and etoposide/iphosphamide (IFO-VP16) was given, which was well tolerated apart from slight anaemia and constipation. After one cycle of chemotherapy the patient reported less pain and a reduction of the volume, redness and inflammation around the knee was observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Europe Hospitals Brussels, Ukkel, Belgium.

No MeSH data available.


Related in: MedlinePlus