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Influence of term of exposure to high-fat diet-induced obesity on myocardial collagen type I and III.

Silva DC, Lima-Leopoldo AP, Leopoldo AS, Campos DH, Nascimento AF, Oliveira Junior SA, Padovani CR, Cicogna AC - Arq. Bras. Cardiol. (2013)

Bottom Line: The time of exposure to obesity was associated with a reduction in collagen type I in Ob30 when compared with Ob15.Obesity did not affect collagen type III expression.However, no effect was seen on myocardial collagen type III expression.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Clinica Medica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil.

ABSTRACT

Background: Obesity is a risk factor for many medical complications; medical research has shown that hemodynamic, morphological and functional abnormalities are correlated with the duration and severity of obesity.

Objective: Present study determined the influence of term of exposure to high-fat diet-induced obesity on myocardial collagen type I and III.

Methods: Thirty-day-old male Wistar rats were randomly distributed into two groups: a control (C) group fed a standard rat chow and an obese (Ob) group alternately fed one of four palatable high-fat diets. Each diet was changed daily, and the rats were maintained on their respective diets for 15 (C15 and Ob15) and 30 (C30 and Ob30) consecutive weeks. Obesity was determined by adiposity index.

Results: The Ob15 group was similar to the C15 group regarding the expression of myocardial collagen type I; however, expression in the Ob30 group was less than C30 group. The time of exposure to obesity was associated with a reduction in collagen type I in Ob30 when compared with Ob15. Obesity did not affect collagen type III expression.

Conclusion: This study showed that the time of exposure to obesity for 30 weeks induced by unsaturated high-fat diet caused a reduction in myocardial collagen type I expression in the obese rats. However, no effect was seen on myocardial collagen type III expression.

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Related in: MedlinePlus

Left ventricle dimensions. Left ventricle (LV) weight (A), and left ventricleweight/tíbia ratio (B) in control (white bars) and obese rats (black bars) after15 and 30 weeks of treatment. Data are mean ± SD; two-way ANOVA and Bonferronipost hoc test. *p < 0.05 vs control group.
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f02: Left ventricle dimensions. Left ventricle (LV) weight (A), and left ventricleweight/tíbia ratio (B) in control (white bars) and obese rats (black bars) after15 and 30 weeks of treatment. Data are mean ± SD; two-way ANOVA and Bonferronipost hoc test. *p < 0.05 vs control group.

Mentions: As shown in Figure 2, the presence of obesityincreased the weight of the left ventricle and as well as LV/tibia length ratio in theOb15 group as compared to the C15 group. However, the LV/tibialength ratio was similar in the Ob30 and C30 groups, suggestingthat exposure to obesity did not have any effect on this variable.


Influence of term of exposure to high-fat diet-induced obesity on myocardial collagen type I and III.

Silva DC, Lima-Leopoldo AP, Leopoldo AS, Campos DH, Nascimento AF, Oliveira Junior SA, Padovani CR, Cicogna AC - Arq. Bras. Cardiol. (2013)

Left ventricle dimensions. Left ventricle (LV) weight (A), and left ventricleweight/tíbia ratio (B) in control (white bars) and obese rats (black bars) after15 and 30 weeks of treatment. Data are mean ± SD; two-way ANOVA and Bonferronipost hoc test. *p < 0.05 vs control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987330&req=5

f02: Left ventricle dimensions. Left ventricle (LV) weight (A), and left ventricleweight/tíbia ratio (B) in control (white bars) and obese rats (black bars) after15 and 30 weeks of treatment. Data are mean ± SD; two-way ANOVA and Bonferronipost hoc test. *p < 0.05 vs control group.
Mentions: As shown in Figure 2, the presence of obesityincreased the weight of the left ventricle and as well as LV/tibia length ratio in theOb15 group as compared to the C15 group. However, the LV/tibialength ratio was similar in the Ob30 and C30 groups, suggestingthat exposure to obesity did not have any effect on this variable.

Bottom Line: The time of exposure to obesity was associated with a reduction in collagen type I in Ob30 when compared with Ob15.Obesity did not affect collagen type III expression.However, no effect was seen on myocardial collagen type III expression.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Clinica Medica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil.

ABSTRACT

Background: Obesity is a risk factor for many medical complications; medical research has shown that hemodynamic, morphological and functional abnormalities are correlated with the duration and severity of obesity.

Objective: Present study determined the influence of term of exposure to high-fat diet-induced obesity on myocardial collagen type I and III.

Methods: Thirty-day-old male Wistar rats were randomly distributed into two groups: a control (C) group fed a standard rat chow and an obese (Ob) group alternately fed one of four palatable high-fat diets. Each diet was changed daily, and the rats were maintained on their respective diets for 15 (C15 and Ob15) and 30 (C30 and Ob30) consecutive weeks. Obesity was determined by adiposity index.

Results: The Ob15 group was similar to the C15 group regarding the expression of myocardial collagen type I; however, expression in the Ob30 group was less than C30 group. The time of exposure to obesity was associated with a reduction in collagen type I in Ob30 when compared with Ob15. Obesity did not affect collagen type III expression.

Conclusion: This study showed that the time of exposure to obesity for 30 weeks induced by unsaturated high-fat diet caused a reduction in myocardial collagen type I expression in the obese rats. However, no effect was seen on myocardial collagen type III expression.

Show MeSH
Related in: MedlinePlus