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Evaluation of endothelial function on atherosclerosis using perfusion index from pulse oximeter.

Menezes IA, Santos MR, Cunha CL - Arq. Bras. Cardiol. (2014)

Bottom Line: The results of IPP were discussed using the literature and estimating their diagnostic and prognostic potential.The endothelium-dependent vasodilatory response measured by IPP was significantly lower in patients with atherosclerosis compared to control group, since 45 seconds after reactive hyperemia.Also, the values of IPP90-120 were significantly lower in patients with atherosclerosis [35% (4 - 53%) vs 73% (55 - 169%); p<0,001].

View Article: PubMed Central - PubMed

Affiliation: Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.

ABSTRACT

Background: Endothelial dysfunction is vascular phenomenon that plays an important role in atherosclerosis development. With the purpose of improving the prevention and treatment of atherosclerotic diseases, the searching for accurate, practical and cheaper methods for evaluating endothelial function have become of interest.

Objectives: Verify the potential of Peripheral Perfusion Index from pulse oximetry (IPP) as a method of endothelial dysfunction evaluation in patients with atherosclerotic diseases.

Methods: There were recruited 18 control patients and 24 patients with atherosclerotic diseases under optimized treatment, in basic health units. The values of IPP were evaluated before and after an endothelial-dependent stimulus, the reactive hyperemia. The values of IPP were also evaluated in period which the major contribution of Nitric Oxide (NO) for the vasodilation occurs (IPP90-120). The results of IPP were discussed using the literature and estimating their diagnostic and prognostic potential.

Results: The endothelium-dependent vasodilatory response measured by IPP was significantly lower in patients with atherosclerosis compared to control group, since 45 seconds after reactive hyperemia. Also, the values of IPP90-120 were significantly lower in patients with atherosclerosis [35% (4 - 53%) vs 73% (55 - 169%); p<0,001]. Similarly, the IPP values were lower in atherosclerosis group when it was separated by gender.

Conclusion: The results of this study, in association with the low cost of pulse oximeter, suggest a good potential for IPP as an endothelial dysfunction evaluation method. New studies must be done in order to clarify this potential and possibly contribute with the prevention and treatment of atherosclerotic diseases.

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Related in: MedlinePlus

Box and whiskers graph showing variations in the peripheral perfusion index inthe 90–120-second interval (ΔPPI90–120) after cuff deflation in menand women in the control and atherosclerosis groups. The graph expressesmedians, interquartile ranges, and maximum and minimum values. * p < 0.05vs. men (controls), ††p < 0.01 vs. women (controls).
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f02: Box and whiskers graph showing variations in the peripheral perfusion index inthe 90–120-second interval (ΔPPI90–120) after cuff deflation in menand women in the control and atherosclerosis groups. The graph expressesmedians, interquartile ranges, and maximum and minimum values. * p < 0.05vs. men (controls), ††p < 0.01 vs. women (controls).

Mentions: In addition, Figures 1 and 2 show that the mean values measured in the 90-120-second(ΔPPI90-120) interval were lower in the atherosclerosis group than inthe control group. These statistically significant differences were observed in bothmen and women.


Evaluation of endothelial function on atherosclerosis using perfusion index from pulse oximeter.

Menezes IA, Santos MR, Cunha CL - Arq. Bras. Cardiol. (2014)

Box and whiskers graph showing variations in the peripheral perfusion index inthe 90–120-second interval (ΔPPI90–120) after cuff deflation in menand women in the control and atherosclerosis groups. The graph expressesmedians, interquartile ranges, and maximum and minimum values. * p < 0.05vs. men (controls), ††p < 0.01 vs. women (controls).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987324&req=5

f02: Box and whiskers graph showing variations in the peripheral perfusion index inthe 90–120-second interval (ΔPPI90–120) after cuff deflation in menand women in the control and atherosclerosis groups. The graph expressesmedians, interquartile ranges, and maximum and minimum values. * p < 0.05vs. men (controls), ††p < 0.01 vs. women (controls).
Mentions: In addition, Figures 1 and 2 show that the mean values measured in the 90-120-second(ΔPPI90-120) interval were lower in the atherosclerosis group than inthe control group. These statistically significant differences were observed in bothmen and women.

Bottom Line: The results of IPP were discussed using the literature and estimating their diagnostic and prognostic potential.The endothelium-dependent vasodilatory response measured by IPP was significantly lower in patients with atherosclerosis compared to control group, since 45 seconds after reactive hyperemia.Also, the values of IPP90-120 were significantly lower in patients with atherosclerosis [35% (4 - 53%) vs 73% (55 - 169%); p<0,001].

View Article: PubMed Central - PubMed

Affiliation: Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.

ABSTRACT

Background: Endothelial dysfunction is vascular phenomenon that plays an important role in atherosclerosis development. With the purpose of improving the prevention and treatment of atherosclerotic diseases, the searching for accurate, practical and cheaper methods for evaluating endothelial function have become of interest.

Objectives: Verify the potential of Peripheral Perfusion Index from pulse oximetry (IPP) as a method of endothelial dysfunction evaluation in patients with atherosclerotic diseases.

Methods: There were recruited 18 control patients and 24 patients with atherosclerotic diseases under optimized treatment, in basic health units. The values of IPP were evaluated before and after an endothelial-dependent stimulus, the reactive hyperemia. The values of IPP were also evaluated in period which the major contribution of Nitric Oxide (NO) for the vasodilation occurs (IPP90-120). The results of IPP were discussed using the literature and estimating their diagnostic and prognostic potential.

Results: The endothelium-dependent vasodilatory response measured by IPP was significantly lower in patients with atherosclerosis compared to control group, since 45 seconds after reactive hyperemia. Also, the values of IPP90-120 were significantly lower in patients with atherosclerosis [35% (4 - 53%) vs 73% (55 - 169%); p<0,001]. Similarly, the IPP values were lower in atherosclerosis group when it was separated by gender.

Conclusion: The results of this study, in association with the low cost of pulse oximeter, suggest a good potential for IPP as an endothelial dysfunction evaluation method. New studies must be done in order to clarify this potential and possibly contribute with the prevention and treatment of atherosclerotic diseases.

Show MeSH
Related in: MedlinePlus