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Echocardiographic parameters and survival in Chagas heart disease with severe systolic dysfunction.

Rassi Ddo C, Vieira ML, Arruda AL, Hotta VT, Furtado RG, Rassi DT, Rassi S - Arq. Bras. Cardiol. (2014)

Bottom Line: Echocardiography provides important information on the cardiac evaluation of patients with heart failure.The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis.To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%.

View Article: PubMed Central - PubMed

Affiliation: Faculdade de Medicina, Hospital das Clínicas, Universidade Federal de Goiás, Goiânia, GO, Brasil.

ABSTRACT

Background: Echocardiography provides important information on the cardiac evaluation of patients with heart failure. The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis.

Objective: To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%.

Methods: Study with retrospective analysis of pre-specified echocardiographic parameters prospectively collected from 60 patients included in the Multicenter Randomized Trial of Cell Therapy in Patients with Heart Diseases (Estudo Multicêntrico Randomizado de Terapia Celular em Cardiopatias) - Chagas heart disease arm. The following parameters were collected: left ventricular systolic and diastolic diameters and volumes; ejection fraction; left atrial diameter; left atrial volume; indexed left atrial volume; systolic pulmonary artery pressure; integral of the aortic flow velocity; myocardial performance index; rate of increase of left ventricular pressure; isovolumic relaxation time; E, A, Em, Am and Sm wave velocities; E wave deceleration time; E/A and E/Em ratios; and mitral regurgitation.

Results: In the mean 24.18-month follow-up, 27 patients died. The mean ejection fraction was 26.6 ± 5.34%. In the multivariate analysis, the parameters ejection fraction (HR = 1.114; p = 0.3704), indexed left atrial volume (HR = 1.033; p < 0.0001) and E/Em ratio (HR = 0.95; p = 0.1261) were excluded. The indexed left atrial volume was an independent predictor in relation to the endpoint, and values > 70.71 mL/m2 were associated with a significant increase in mortality (log rank p < 0.0001).

Conclusion: The indexed left atrial volume was the only independent predictor of mortality in this population of Chagasic patients with severe systolic dysfunction.

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Related in: MedlinePlus

Kapplan-Meier curve with analysis of overall survival in the study population
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f01: Kapplan-Meier curve with analysis of overall survival in the study population

Mentions: Cardiovascular deaths occurred in 27 (45%) of the 60 patients in a mean follow-up of 24months (Figure 1). All remained with optimizeddrug therapy and did not receive resynchronization therapy or implantablecardio-defibrillator during the follow-up.


Echocardiographic parameters and survival in Chagas heart disease with severe systolic dysfunction.

Rassi Ddo C, Vieira ML, Arruda AL, Hotta VT, Furtado RG, Rassi DT, Rassi S - Arq. Bras. Cardiol. (2014)

Kapplan-Meier curve with analysis of overall survival in the study population
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987318&req=5

f01: Kapplan-Meier curve with analysis of overall survival in the study population
Mentions: Cardiovascular deaths occurred in 27 (45%) of the 60 patients in a mean follow-up of 24months (Figure 1). All remained with optimizeddrug therapy and did not receive resynchronization therapy or implantablecardio-defibrillator during the follow-up.

Bottom Line: Echocardiography provides important information on the cardiac evaluation of patients with heart failure.The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis.To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%.

View Article: PubMed Central - PubMed

Affiliation: Faculdade de Medicina, Hospital das Clínicas, Universidade Federal de Goiás, Goiânia, GO, Brasil.

ABSTRACT

Background: Echocardiography provides important information on the cardiac evaluation of patients with heart failure. The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis.

Objective: To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%.

Methods: Study with retrospective analysis of pre-specified echocardiographic parameters prospectively collected from 60 patients included in the Multicenter Randomized Trial of Cell Therapy in Patients with Heart Diseases (Estudo Multicêntrico Randomizado de Terapia Celular em Cardiopatias) - Chagas heart disease arm. The following parameters were collected: left ventricular systolic and diastolic diameters and volumes; ejection fraction; left atrial diameter; left atrial volume; indexed left atrial volume; systolic pulmonary artery pressure; integral of the aortic flow velocity; myocardial performance index; rate of increase of left ventricular pressure; isovolumic relaxation time; E, A, Em, Am and Sm wave velocities; E wave deceleration time; E/A and E/Em ratios; and mitral regurgitation.

Results: In the mean 24.18-month follow-up, 27 patients died. The mean ejection fraction was 26.6 ± 5.34%. In the multivariate analysis, the parameters ejection fraction (HR = 1.114; p = 0.3704), indexed left atrial volume (HR = 1.033; p < 0.0001) and E/Em ratio (HR = 0.95; p = 0.1261) were excluded. The indexed left atrial volume was an independent predictor in relation to the endpoint, and values > 70.71 mL/m2 were associated with a significant increase in mortality (log rank p < 0.0001).

Conclusion: The indexed left atrial volume was the only independent predictor of mortality in this population of Chagasic patients with severe systolic dysfunction.

Show MeSH
Related in: MedlinePlus