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Correlation between serum adiponectin and clinical characteristics, biochemical parameters in Indian women with polycystic ovary syndrome.

Ramanand SJ, Ramanand JB, Ghongane BB, Patwardhan MH, Patwardhan VM, Ghanghas R, Halasawadekar NR, Patil P - Indian J Endocrinol Metab (2014)

Bottom Line: It was significantly lower in patients with acanthosis nigricans (AN) as compared with those without AN (8.4 ± 5.9 vs 15 ± 11, P = 0.038).Adiponectin levels decrease as age advances.Low levels of adiponectin possibly contributes to the development of dermal manifestation (AN) of insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India.

ABSTRACT

Background: Polycystic ovary syndrome (PCOS) is a common disorder. PCOS women are at a high risk for insulin resistance and metabolic syndrome (MS). Adiponectin is positively related to insulin sensitivity. It has a preventive role in atherogenesis and MS. The present work was conducted to study the correlation between serum adiponectin levels and clinical characteristics and biochemical parameters in PCOS patients.

Materials and methods: A prospective study in 49 newly diagnosed (as per Rotterdam criteria) Indian PCOS women was conducted. PCOS women were clinically examined and investigated for biochemical parameters.

Results: The mean serum adiponectin was 12 ± 9.4 μg/mL (range 0.47-45). Hypoadiponectinemia (serum adiponectin <4 μg/mL) was present in 22% patients. Age and adiponectin correlated significantly and inversely (r = -0.42, P = 0.027). Overweight/obese patients had lower mean adiponectin levels than normal weight (11.62 ± 9.5 vs 13.58 ± 9.5, P = 0.56). It was significantly lower in patients with acanthosis nigricans (AN) as compared with those without AN (8.4 ± 5.9 vs 15 ± 11, P = 0.038). Hirsute patients showed lower mean adiponectin levels than nonhirsute (10 ± 7.3 vs 13 ± 10, P = 0.57). A positive, insignificant correlation was observed between serum adiponectin and cholesterol, low-density lipoprotein, follicle stimulating hormone (FSH), thyroid stimulating hormone, levels. A negative insignificant correlation existed between serum adiponectin and luteinizing hormone (LH), LH: FSH ratio, prolactin, dehydroepiandrosterone, testosterone, triglyceride, high-density lipoprotein, fasting blood glucose, fasting insulin, and Homeostasis Model Assessment.

Conclusion: Hypoadiponectinemia is present in one-fifth of women with PCOS. Adiponectin levels decrease as age advances. Low levels of adiponectin possibly contributes to the development of dermal manifestation (AN) of insulin resistance.

No MeSH data available.


Related in: MedlinePlus

Correlation between adiponectin and age in women with polycystic ovary syndrome (r = −0.42, P = 0.0027**)
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Figure 1: Correlation between adiponectin and age in women with polycystic ovary syndrome (r = −0.42, P = 0.0027**)

Mentions: The mean age of PCOS patients was 22 ± 5.0 years (range, 14-35). Hypoadiponectinemia (serum adiponectin < 4 μg/mL) was observed in 22% of the patients (normal weight 1/11, overweight/obese 10/38) and was independent of obesity Figure 1 shows distribution of adiponectin values and inverse correlation between adiponectin and age. The relation is highly significant with correlation coefficient of −0.42** (P value, −0.027).


Correlation between serum adiponectin and clinical characteristics, biochemical parameters in Indian women with polycystic ovary syndrome.

Ramanand SJ, Ramanand JB, Ghongane BB, Patwardhan MH, Patwardhan VM, Ghanghas R, Halasawadekar NR, Patil P - Indian J Endocrinol Metab (2014)

Correlation between adiponectin and age in women with polycystic ovary syndrome (r = −0.42, P = 0.0027**)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987275&req=5

Figure 1: Correlation between adiponectin and age in women with polycystic ovary syndrome (r = −0.42, P = 0.0027**)
Mentions: The mean age of PCOS patients was 22 ± 5.0 years (range, 14-35). Hypoadiponectinemia (serum adiponectin < 4 μg/mL) was observed in 22% of the patients (normal weight 1/11, overweight/obese 10/38) and was independent of obesity Figure 1 shows distribution of adiponectin values and inverse correlation between adiponectin and age. The relation is highly significant with correlation coefficient of −0.42** (P value, −0.027).

Bottom Line: It was significantly lower in patients with acanthosis nigricans (AN) as compared with those without AN (8.4 ± 5.9 vs 15 ± 11, P = 0.038).Adiponectin levels decrease as age advances.Low levels of adiponectin possibly contributes to the development of dermal manifestation (AN) of insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India.

ABSTRACT

Background: Polycystic ovary syndrome (PCOS) is a common disorder. PCOS women are at a high risk for insulin resistance and metabolic syndrome (MS). Adiponectin is positively related to insulin sensitivity. It has a preventive role in atherogenesis and MS. The present work was conducted to study the correlation between serum adiponectin levels and clinical characteristics and biochemical parameters in PCOS patients.

Materials and methods: A prospective study in 49 newly diagnosed (as per Rotterdam criteria) Indian PCOS women was conducted. PCOS women were clinically examined and investigated for biochemical parameters.

Results: The mean serum adiponectin was 12 ± 9.4 μg/mL (range 0.47-45). Hypoadiponectinemia (serum adiponectin <4 μg/mL) was present in 22% patients. Age and adiponectin correlated significantly and inversely (r = -0.42, P = 0.027). Overweight/obese patients had lower mean adiponectin levels than normal weight (11.62 ± 9.5 vs 13.58 ± 9.5, P = 0.56). It was significantly lower in patients with acanthosis nigricans (AN) as compared with those without AN (8.4 ± 5.9 vs 15 ± 11, P = 0.038). Hirsute patients showed lower mean adiponectin levels than nonhirsute (10 ± 7.3 vs 13 ± 10, P = 0.57). A positive, insignificant correlation was observed between serum adiponectin and cholesterol, low-density lipoprotein, follicle stimulating hormone (FSH), thyroid stimulating hormone, levels. A negative insignificant correlation existed between serum adiponectin and luteinizing hormone (LH), LH: FSH ratio, prolactin, dehydroepiandrosterone, testosterone, triglyceride, high-density lipoprotein, fasting blood glucose, fasting insulin, and Homeostasis Model Assessment.

Conclusion: Hypoadiponectinemia is present in one-fifth of women with PCOS. Adiponectin levels decrease as age advances. Low levels of adiponectin possibly contributes to the development of dermal manifestation (AN) of insulin resistance.

No MeSH data available.


Related in: MedlinePlus