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Mentha piperita in nephrotoxicity--a possible intervention to ameliorate renal derangements associated with gentamicin.

Ullah N, Khan MA, Khan T, Asif AH, Ahmad W - Indian J Pharmacol (2014 Mar-Apr)

Bottom Line: Free radical generation has a strong role in the pathogenesis of renal damage associated with the use of gentamicin.Further the plant did not influence the efficacy of gentamicin with respect to its antimicrobial properties.Co-therapy of M. piperita with gentamicin successfully attenuated biochemical kidney functioning derangements and morphological changes associated with gentamicin.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, University of Swabi, Swabi, Pakistan.

ABSTRACT

Objective: Free radical generation has a strong role in the pathogenesis of renal damage associated with the use of gentamicin. Therefore, the present study was carried out to evaluate the renoprotective effect of Mentha piperita against gentamicin induced nephrotoxicity.

Materials and methods: A total of 24 male rabbits were divided into 4 groups receiving normal saline, gentamicin, M. piperita extract and co-therapy of extract and gentamicin respectively. Gentamicin was provided as 80 mg/kg/day intramuscularly and extract was given 200 mg/kg/day orally for a period of 21 days. Serum and urinary biochemical parameters and histological changes were studied for each group. The impact of the extract on the antibacterial action of gentamicin was also evaluated.

Results: Animals treated with gentamicin showed derangements in serum and urinary biochemical parameters. These alterations were reversed by treatment with M. piperita extract. The histological changes showed in gentamicin group were also reverted by treatment with the extract. Further the plant did not influence the efficacy of gentamicin with respect to its antimicrobial properties.

Conclusion: Co-therapy of M. piperita with gentamicin successfully attenuated biochemical kidney functioning derangements and morphological changes associated with gentamicin.

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Related in: MedlinePlus

Photomicrograph showing histopatological examination of renal cortex (a) Group C, presenting no common abnormality (b) Group G, presenting glomerular atropy with hydropic changes and proximal tubular cell necrosis with loss of cellular pattern (c) Group GM-pi, presenting normal glomeruli with no evidence of necrosis or ruptured tubules (d) Group M-pi, also presenting normal structures
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Figure 1: Photomicrograph showing histopatological examination of renal cortex (a) Group C, presenting no common abnormality (b) Group G, presenting glomerular atropy with hydropic changes and proximal tubular cell necrosis with loss of cellular pattern (c) Group GM-pi, presenting normal glomeruli with no evidence of necrosis or ruptured tubules (d) Group M-pi, also presenting normal structures

Mentions: Histological examination of the kidneys of Group G showed proximal tubular necrosis with loss of cellular pattern. Glomerular atrophy and ruptured tubules with hydropic changes were also observed [Figure 1b]. While in case of Group C animals’ normal tubules with no evidence of necrosis and normal glomeruli or hydropic changes were observed [Figure 1a]. Groups GM-pi and M-pi also showed normal histology with no common abnormality or significant toxicity [Figure 1c and d].


Mentha piperita in nephrotoxicity--a possible intervention to ameliorate renal derangements associated with gentamicin.

Ullah N, Khan MA, Khan T, Asif AH, Ahmad W - Indian J Pharmacol (2014 Mar-Apr)

Photomicrograph showing histopatological examination of renal cortex (a) Group C, presenting no common abnormality (b) Group G, presenting glomerular atropy with hydropic changes and proximal tubular cell necrosis with loss of cellular pattern (c) Group GM-pi, presenting normal glomeruli with no evidence of necrosis or ruptured tubules (d) Group M-pi, also presenting normal structures
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3987184&req=5

Figure 1: Photomicrograph showing histopatological examination of renal cortex (a) Group C, presenting no common abnormality (b) Group G, presenting glomerular atropy with hydropic changes and proximal tubular cell necrosis with loss of cellular pattern (c) Group GM-pi, presenting normal glomeruli with no evidence of necrosis or ruptured tubules (d) Group M-pi, also presenting normal structures
Mentions: Histological examination of the kidneys of Group G showed proximal tubular necrosis with loss of cellular pattern. Glomerular atrophy and ruptured tubules with hydropic changes were also observed [Figure 1b]. While in case of Group C animals’ normal tubules with no evidence of necrosis and normal glomeruli or hydropic changes were observed [Figure 1a]. Groups GM-pi and M-pi also showed normal histology with no common abnormality or significant toxicity [Figure 1c and d].

Bottom Line: Free radical generation has a strong role in the pathogenesis of renal damage associated with the use of gentamicin.Further the plant did not influence the efficacy of gentamicin with respect to its antimicrobial properties.Co-therapy of M. piperita with gentamicin successfully attenuated biochemical kidney functioning derangements and morphological changes associated with gentamicin.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, University of Swabi, Swabi, Pakistan.

ABSTRACT

Objective: Free radical generation has a strong role in the pathogenesis of renal damage associated with the use of gentamicin. Therefore, the present study was carried out to evaluate the renoprotective effect of Mentha piperita against gentamicin induced nephrotoxicity.

Materials and methods: A total of 24 male rabbits were divided into 4 groups receiving normal saline, gentamicin, M. piperita extract and co-therapy of extract and gentamicin respectively. Gentamicin was provided as 80 mg/kg/day intramuscularly and extract was given 200 mg/kg/day orally for a period of 21 days. Serum and urinary biochemical parameters and histological changes were studied for each group. The impact of the extract on the antibacterial action of gentamicin was also evaluated.

Results: Animals treated with gentamicin showed derangements in serum and urinary biochemical parameters. These alterations were reversed by treatment with M. piperita extract. The histological changes showed in gentamicin group were also reverted by treatment with the extract. Further the plant did not influence the efficacy of gentamicin with respect to its antimicrobial properties.

Conclusion: Co-therapy of M. piperita with gentamicin successfully attenuated biochemical kidney functioning derangements and morphological changes associated with gentamicin.

Show MeSH
Related in: MedlinePlus