Uterine cervix cancer treatment at Radiumhemmet: 90 years' experience. Time trends of age, stage, and histopathology distribution.
Bottom Line: Since the introduction of screening programs for cervical cancer (CC) the incidence has decreased and CC is discovered at an earlier stage.A reduction in squamous cell carcinoma (SCC) cases and a sixfold increase in the proportion of adenocarcinoma (AC) cases were observed.The changes in the distribution by age, stage, and histopathology during this 90-year period are probably associated with: improved social conditions and increased access to health care, the introduction of screening programs for CC in the 1960s, and a change in the risk factors for CC (changed sexual behavior, introduction of contraceptive pills, and changed smoking habits).
Affiliation: Department of Gynecological Oncology, Radiumhemmet, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.Show MeSH
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Mentions: The stage distribution shows a continuous shift toward earlier stages at diagnosis during the study period (Fig. 5). Starting as early as 1940, the percentage of stage I cases increased and this has been even more pronounced since 1960. The percentage of cases in stages III and IV decreased in 1930, but after 1960 the drop has leveled out. Stage II cases increased from 1920 to 1959 and thereafter decreased.
Affiliation: Department of Gynecological Oncology, Radiumhemmet, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.