Limits...
No increased risk of herpes zoster found in cirrhotic patients: a nationwide population-based study in Taiwan.

Wu PH, Lin YT, Kuo CN, Chang WC, Chang WP - PLoS ONE (2014)

Bottom Line: The study cohort included cirrhotic patients between 1998 and 2005 (n = 4667), and a ratio of 1:5 randomly sampled age- and gender-matched control patients (n = 23,335).No increased risk of herpes zoster was found in LC patients after stratification by age, gender, urbanization level, income, geographic region, and all comorbidities.This large nationwide population-based cohort study suggests that there is no increased risk for herpes zoster among people who have LC compared to a matching population.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

ABSTRACT

Background: The association between liver cirrhosis (LC) and herpes zoster has rarely been studied. We investigated the hypothesis that LC, known as an immunodeficiency disease, may increase the risk of herpes zoster using a national health insurance database in Taiwan.

Materials and methods: The study cohort included cirrhotic patients between 1998 and 2005 (n = 4667), and a ratio of 1:5 randomly sampled age- and gender-matched control patients (n = 23,335). All subjects were followed up for 5 years from the date of cohort entry to identify whether or not they had developed herpes zoster. Cox proportional-hazard regressions were performed to evaluate 5-year herpes zoster-free survival rates.

Results: Of all patients, 523 patients developed herpes zoster during the 5-year follow-up period, among whom 82 were LC patients and 441 were in the comparison cohort. The adjusted hazard ratio (AHR) of herpes zoster in patients with LC was not higher (AHR: 0.77, 95% confidence interval: 0.59-1.01, p = 0.06) than that of the controls during the 5-year follow-up. No increased risk of herpes zoster was found in LC patients after stratification by age, gender, urbanization level, income, geographic region, and all comorbidities.

Conclusions: This large nationwide population-based cohort study suggests that there is no increased risk for herpes zoster among people who have LC compared to a matching population.

Show MeSH

Related in: MedlinePlus

Herpes zoster-free survival rates for patient with liver cirrhosis and comparison groups in 1998–2005.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3974756&req=5

pone-0093443-g002: Herpes zoster-free survival rates for patient with liver cirrhosis and comparison groups in 1998–2005.

Mentions: There were 523 patients diagnosed with herpes zoster during the 5-year follow-up, including 82 LC patients (1.8%) and 441 patients in the comparison cohort (1.9%). The Kaplan-Meier survival curves are shown in Figure 2. The curves demonstrate no significant difference in herpes zoster-free survival rates between the LC and comparison cohorts (log-rank test p = 0.55).


No increased risk of herpes zoster found in cirrhotic patients: a nationwide population-based study in Taiwan.

Wu PH, Lin YT, Kuo CN, Chang WC, Chang WP - PLoS ONE (2014)

Herpes zoster-free survival rates for patient with liver cirrhosis and comparison groups in 1998–2005.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3974756&req=5

pone-0093443-g002: Herpes zoster-free survival rates for patient with liver cirrhosis and comparison groups in 1998–2005.
Mentions: There were 523 patients diagnosed with herpes zoster during the 5-year follow-up, including 82 LC patients (1.8%) and 441 patients in the comparison cohort (1.9%). The Kaplan-Meier survival curves are shown in Figure 2. The curves demonstrate no significant difference in herpes zoster-free survival rates between the LC and comparison cohorts (log-rank test p = 0.55).

Bottom Line: The study cohort included cirrhotic patients between 1998 and 2005 (n = 4667), and a ratio of 1:5 randomly sampled age- and gender-matched control patients (n = 23,335).No increased risk of herpes zoster was found in LC patients after stratification by age, gender, urbanization level, income, geographic region, and all comorbidities.This large nationwide population-based cohort study suggests that there is no increased risk for herpes zoster among people who have LC compared to a matching population.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

ABSTRACT

Background: The association between liver cirrhosis (LC) and herpes zoster has rarely been studied. We investigated the hypothesis that LC, known as an immunodeficiency disease, may increase the risk of herpes zoster using a national health insurance database in Taiwan.

Materials and methods: The study cohort included cirrhotic patients between 1998 and 2005 (n = 4667), and a ratio of 1:5 randomly sampled age- and gender-matched control patients (n = 23,335). All subjects were followed up for 5 years from the date of cohort entry to identify whether or not they had developed herpes zoster. Cox proportional-hazard regressions were performed to evaluate 5-year herpes zoster-free survival rates.

Results: Of all patients, 523 patients developed herpes zoster during the 5-year follow-up period, among whom 82 were LC patients and 441 were in the comparison cohort. The adjusted hazard ratio (AHR) of herpes zoster in patients with LC was not higher (AHR: 0.77, 95% confidence interval: 0.59-1.01, p = 0.06) than that of the controls during the 5-year follow-up. No increased risk of herpes zoster was found in LC patients after stratification by age, gender, urbanization level, income, geographic region, and all comorbidities.

Conclusions: This large nationwide population-based cohort study suggests that there is no increased risk for herpes zoster among people who have LC compared to a matching population.

Show MeSH
Related in: MedlinePlus