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The relationship of cancer stem cells in urological cancers.

Adamowicz J, Pokrywczyńska M, Tworkiewicz J, Wolski Z, Drewa T - Cent European J Urol (2013)

Bottom Line: Better understanding of their role in prostate, urothelial and kidney cancer origin, growth and progression opens new pathways in development of more effective treatment methods.However there are still many issues before advances in this field can be introduced for clinical application.This review addresses current achievements in cancer stem cells research in uro-oncology.

View Article: PubMed Central - PubMed

Affiliation: Nicolaus Copernicus University, Faculty of Medicine, Department of Tissue Engineering, Bydgoszcz, Poland ; Department of General, Oncologic and Pediatric Urology, University Hospital, Bydgoszcz, University of Nicolaus Copernicus, Poland.

ABSTRACT
Numerous studies are ongoing to identify and isolate cancer stem cells from cancers of genito-urinary tracts. Better understanding of their role in prostate, urothelial and kidney cancer origin, growth and progression opens new pathways in development of more effective treatment methods. However there are still many issues before advances in this field can be introduced for clinical application. This review addresses current achievements in cancer stem cells research in uro-oncology.

No MeSH data available.


Related in: MedlinePlus

The figure presents the model of cellular hierarchy of prostate including cancer origin pathway.
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Figure 0002: The figure presents the model of cellular hierarchy of prostate including cancer origin pathway.

Mentions: Prostate Cancer Stem Cells (PCSC) represent only a small fraction of all tumor cells. Collins et al estimated that 0.1% of prostate cancer tumor cells correspond to characteristics of stem cells [12]. Despite low numbers of stem cells, their successful identification were reported in several studies. The main strategy of CSC identification utilized the assumption that normal prostate stem cells share markers with PCSC. The following stem cell markers were used in different studies CD44, CD133, α2β1hi integrin, FAM65B, MFI2, and LEF1 in order to detect PCSCs [13]. The results of numerous studies which tried to answer the question about the cellular origin of PCSCs are inconclusive. According to the current state of research origin of PCSC comprise: Transient Proliferating/Amplifying (TP/A) intermediate stem cells, prostate stem cells, basal cells or luminal cells (Figure 2) [14]. There is approximately equally number of research reports informing that PCSC developed either from basal layer or luminal layer of prostatic epithelium (Figure 2A, B).


The relationship of cancer stem cells in urological cancers.

Adamowicz J, Pokrywczyńska M, Tworkiewicz J, Wolski Z, Drewa T - Cent European J Urol (2013)

The figure presents the model of cellular hierarchy of prostate including cancer origin pathway.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3974476&req=5

Figure 0002: The figure presents the model of cellular hierarchy of prostate including cancer origin pathway.
Mentions: Prostate Cancer Stem Cells (PCSC) represent only a small fraction of all tumor cells. Collins et al estimated that 0.1% of prostate cancer tumor cells correspond to characteristics of stem cells [12]. Despite low numbers of stem cells, their successful identification were reported in several studies. The main strategy of CSC identification utilized the assumption that normal prostate stem cells share markers with PCSC. The following stem cell markers were used in different studies CD44, CD133, α2β1hi integrin, FAM65B, MFI2, and LEF1 in order to detect PCSCs [13]. The results of numerous studies which tried to answer the question about the cellular origin of PCSCs are inconclusive. According to the current state of research origin of PCSC comprise: Transient Proliferating/Amplifying (TP/A) intermediate stem cells, prostate stem cells, basal cells or luminal cells (Figure 2) [14]. There is approximately equally number of research reports informing that PCSC developed either from basal layer or luminal layer of prostatic epithelium (Figure 2A, B).

Bottom Line: Better understanding of their role in prostate, urothelial and kidney cancer origin, growth and progression opens new pathways in development of more effective treatment methods.However there are still many issues before advances in this field can be introduced for clinical application.This review addresses current achievements in cancer stem cells research in uro-oncology.

View Article: PubMed Central - PubMed

Affiliation: Nicolaus Copernicus University, Faculty of Medicine, Department of Tissue Engineering, Bydgoszcz, Poland ; Department of General, Oncologic and Pediatric Urology, University Hospital, Bydgoszcz, University of Nicolaus Copernicus, Poland.

ABSTRACT
Numerous studies are ongoing to identify and isolate cancer stem cells from cancers of genito-urinary tracts. Better understanding of their role in prostate, urothelial and kidney cancer origin, growth and progression opens new pathways in development of more effective treatment methods. However there are still many issues before advances in this field can be introduced for clinical application. This review addresses current achievements in cancer stem cells research in uro-oncology.

No MeSH data available.


Related in: MedlinePlus