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Asymptomatic bacteriuria in postmenopausal women with diabetes mellitus.

Kasyan G, Berketova TY, Rogozin AK, Pushkar DY - Cent European J Urol (2013)

Bottom Line: Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis.In group 2, there were no significant changes revealed.Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

View Article: PubMed Central - PubMed

Affiliation: Urology Department of Moscow State University of Medicine and Dentistry, Moscow, Russian Federation.

ABSTRACT

Introduction: An evaluation of efficacy of the management of urinary tract infections by using local forms of Estriol in postmenopausal women with type II diabetes and asymptomatic bacteriuria.

Material and methods: The study was conducted in two stages. The first stage: a prospective cross-sectional study to identify patients with asymptomatic bacteriuria. During this stage, 414 postmenopausal women with type II diabetes, but without clinical symptoms of urinary tract infection, were investigated. In the second stage, women with asymptomatic bacteriuria (87 women) were randomized to two groups: the first group was the main group receiving 0.5 mg of Estriol as a vaginal cream, the second group was the control group. The study lasted 12 months.

Results: After 12 months of the study, asymptomatic bacteriuria was revealed in 19.4% of women in the group 1 and 68.4% of women in the group 2 (p <0.001), and symptomatic urinary tract infection in 8.3% of women in the group 1 and 18.4% of women in the group 2 (p <0.001). There was no connection revealed between asymptomatic bacteriuria and HbA1с. Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis. In group 2, there were no significant changes revealed.

Conclusions: Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

No MeSH data available.


Related in: MedlinePlus

Prevalence of symptoms of atrophic vaginitis at baseline and after 12 months.
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Figure 0003: Prevalence of symptoms of atrophic vaginitis at baseline and after 12 months.

Mentions: During the study the nature of the complaints and their severity were analyzed. At the beginning and the end of the study patients were asked to answer the question, whether they notice any unpleasant, disturbing sensation in the vagina. Thus, at the beginning of the study, vaginal dryness was noted in 22 (51.2%), itching of the vulva in 14 (38.6%), dyspareunia in 21 (48.8%) patients of the main group and in 20 (45.5%), 17 (32.6%) and 24 (54.5%) patients of the control group, respectively. After 12 months, in patients of the first group, the frequency of detected signs of atrophic vaginitis decreased: thus, vaginal dryness persisted in two (5.7%) (p <0.001), itching of the vulva in four (11.1%) (p <0, 05), and dyspareunia in six (16.7%) (p >0.05) patients, whereas in patients of the second group, significant changes were not noted: vaginal dryness was found in 19 (50.0%) (p >0.05), itching of the vulva in 18 (47.4%) (p >0.05), and dyspareunia in 17 (44.7%) (p >0.05) patients (Figure 3).


Asymptomatic bacteriuria in postmenopausal women with diabetes mellitus.

Kasyan G, Berketova TY, Rogozin AK, Pushkar DY - Cent European J Urol (2013)

Prevalence of symptoms of atrophic vaginitis at baseline and after 12 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3974470&req=5

Figure 0003: Prevalence of symptoms of atrophic vaginitis at baseline and after 12 months.
Mentions: During the study the nature of the complaints and their severity were analyzed. At the beginning and the end of the study patients were asked to answer the question, whether they notice any unpleasant, disturbing sensation in the vagina. Thus, at the beginning of the study, vaginal dryness was noted in 22 (51.2%), itching of the vulva in 14 (38.6%), dyspareunia in 21 (48.8%) patients of the main group and in 20 (45.5%), 17 (32.6%) and 24 (54.5%) patients of the control group, respectively. After 12 months, in patients of the first group, the frequency of detected signs of atrophic vaginitis decreased: thus, vaginal dryness persisted in two (5.7%) (p <0.001), itching of the vulva in four (11.1%) (p <0, 05), and dyspareunia in six (16.7%) (p >0.05) patients, whereas in patients of the second group, significant changes were not noted: vaginal dryness was found in 19 (50.0%) (p >0.05), itching of the vulva in 18 (47.4%) (p >0.05), and dyspareunia in 17 (44.7%) (p >0.05) patients (Figure 3).

Bottom Line: Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis.In group 2, there were no significant changes revealed.Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

View Article: PubMed Central - PubMed

Affiliation: Urology Department of Moscow State University of Medicine and Dentistry, Moscow, Russian Federation.

ABSTRACT

Introduction: An evaluation of efficacy of the management of urinary tract infections by using local forms of Estriol in postmenopausal women with type II diabetes and asymptomatic bacteriuria.

Material and methods: The study was conducted in two stages. The first stage: a prospective cross-sectional study to identify patients with asymptomatic bacteriuria. During this stage, 414 postmenopausal women with type II diabetes, but without clinical symptoms of urinary tract infection, were investigated. In the second stage, women with asymptomatic bacteriuria (87 women) were randomized to two groups: the first group was the main group receiving 0.5 mg of Estriol as a vaginal cream, the second group was the control group. The study lasted 12 months.

Results: After 12 months of the study, asymptomatic bacteriuria was revealed in 19.4% of women in the group 1 and 68.4% of women in the group 2 (p <0.001), and symptomatic urinary tract infection in 8.3% of women in the group 1 and 18.4% of women in the group 2 (p <0.001). There was no connection revealed between asymptomatic bacteriuria and HbA1с. Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis. In group 2, there were no significant changes revealed.

Conclusions: Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

No MeSH data available.


Related in: MedlinePlus