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Asymptomatic bacteriuria in postmenopausal women with diabetes mellitus.

Kasyan G, Berketova TY, Rogozin AK, Pushkar DY - Cent European J Urol (2013)

Bottom Line: Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis.In group 2, there were no significant changes revealed.Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

View Article: PubMed Central - PubMed

Affiliation: Urology Department of Moscow State University of Medicine and Dentistry, Moscow, Russian Federation.

ABSTRACT

Introduction: An evaluation of efficacy of the management of urinary tract infections by using local forms of Estriol in postmenopausal women with type II diabetes and asymptomatic bacteriuria.

Material and methods: The study was conducted in two stages. The first stage: a prospective cross-sectional study to identify patients with asymptomatic bacteriuria. During this stage, 414 postmenopausal women with type II diabetes, but without clinical symptoms of urinary tract infection, were investigated. In the second stage, women with asymptomatic bacteriuria (87 women) were randomized to two groups: the first group was the main group receiving 0.5 mg of Estriol as a vaginal cream, the second group was the control group. The study lasted 12 months.

Results: After 12 months of the study, asymptomatic bacteriuria was revealed in 19.4% of women in the group 1 and 68.4% of women in the group 2 (p <0.001), and symptomatic urinary tract infection in 8.3% of women in the group 1 and 18.4% of women in the group 2 (p <0.001). There was no connection revealed between asymptomatic bacteriuria and HbA1с. Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis. In group 2, there were no significant changes revealed.

Conclusions: Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

No MeSH data available.


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The incidence of AB and UTI after 12 months from the start of the study.
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Figure 0001: The incidence of AB and UTI after 12 months from the start of the study.

Mentions: At the beginning of the study, all patients were diagnosed with AB, but clinical forms of UTI were excluded. After 12 months of the beginning of the treatment, a decrease of the frequency of AB to 19.4% and symptomatic UTI to 8.3% was detected in patients of the main group. In the control group, AB was detected in 68.4% of patients, and symptomatic UTI in 18.4% (p <0.001) (Figure 1). However, during the study we did not reveal any relations between level of HBA1C and frequency of AB. At the end of the study HBA1C was ≥7.5% in 13 (36.1%) of patients in main group, AB was revealed in 7 (19.4%) of patients, AB was diagnosed in 26 (68.4%) (p <0.001) of patients in control group in spite of the fact that HBA1C at the 9th months was ≥7.5% in 12 (31.6%) of patients (Table 3).


Asymptomatic bacteriuria in postmenopausal women with diabetes mellitus.

Kasyan G, Berketova TY, Rogozin AK, Pushkar DY - Cent European J Urol (2013)

The incidence of AB and UTI after 12 months from the start of the study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3974470&req=5

Figure 0001: The incidence of AB and UTI after 12 months from the start of the study.
Mentions: At the beginning of the study, all patients were diagnosed with AB, but clinical forms of UTI were excluded. After 12 months of the beginning of the treatment, a decrease of the frequency of AB to 19.4% and symptomatic UTI to 8.3% was detected in patients of the main group. In the control group, AB was detected in 68.4% of patients, and symptomatic UTI in 18.4% (p <0.001) (Figure 1). However, during the study we did not reveal any relations between level of HBA1C and frequency of AB. At the end of the study HBA1C was ≥7.5% in 13 (36.1%) of patients in main group, AB was revealed in 7 (19.4%) of patients, AB was diagnosed in 26 (68.4%) (p <0.001) of patients in control group in spite of the fact that HBA1C at the 9th months was ≥7.5% in 12 (31.6%) of patients (Table 3).

Bottom Line: Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis.In group 2, there were no significant changes revealed.Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

View Article: PubMed Central - PubMed

Affiliation: Urology Department of Moscow State University of Medicine and Dentistry, Moscow, Russian Federation.

ABSTRACT

Introduction: An evaluation of efficacy of the management of urinary tract infections by using local forms of Estriol in postmenopausal women with type II diabetes and asymptomatic bacteriuria.

Material and methods: The study was conducted in two stages. The first stage: a prospective cross-sectional study to identify patients with asymptomatic bacteriuria. During this stage, 414 postmenopausal women with type II diabetes, but without clinical symptoms of urinary tract infection, were investigated. In the second stage, women with asymptomatic bacteriuria (87 women) were randomized to two groups: the first group was the main group receiving 0.5 mg of Estriol as a vaginal cream, the second group was the control group. The study lasted 12 months.

Results: After 12 months of the study, asymptomatic bacteriuria was revealed in 19.4% of women in the group 1 and 68.4% of women in the group 2 (p <0.001), and symptomatic urinary tract infection in 8.3% of women in the group 1 and 18.4% of women in the group 2 (p <0.001). There was no connection revealed between asymptomatic bacteriuria and HbA1с. Using Estriol in group 1 led to an increase in VHI, the appearance of lactobacilli in the vaginal smear, and the decrease of symptom frequency in atrophic vaginitis. In group 2, there were no significant changes revealed.

Conclusions: Usage of local forms of Estriol effectively prevents and decreases the frequency of asymptomatic bacteriuria and urinary tract infection in postmenopausal women suffering with diabetes mellitus.

No MeSH data available.


Related in: MedlinePlus