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Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil.

Baio PV, Mota HF, Freitas AD, Gomes DL, Ramos JN, Sant'Anna LO, Souza MC, Camello TC, Hirata Junior R, Vieira VV, Mattos-Guaraldi AL - Mem. Inst. Oswaldo Cruz (2013)

Bottom Line: C. striatum identification was confirmed by 16S rRNA and rpoB gene sequencing.Fifteen C. striatum strains were isolated from adults (half of whom were 50 years of age and older).C. striatum was mostly isolated in pure culture from tracheal aspirates of patients undergoing endotracheal intubation procedures.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Difteria e Corinebactérias de Importância Clínica, Departamento de Microbiologia, Imunologia e Patologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

ABSTRACT
Corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. Here, we document a nosocomial outbreak caused by multidrug-resistant (MDR) C. striatum in Rio de Janeiro, Brazil. C. striatum identification was confirmed by 16S rRNA and rpoB gene sequencing. Fifteen C. striatum strains were isolated from adults (half of whom were 50 years of age and older). C. striatum was mostly isolated in pure culture from tracheal aspirates of patients undergoing endotracheal intubation procedures. The analysis by pulsed-field gel electrophoresis (PFGE) indicated the presence of four PFGE profiles, including two related clones of MDR strains (PFGE I and II). The data demonstrated the predominance of PFGE type I, comprising 11 MDR isolates that were mostly isolated from intensive care units and surgical wards. A potential causal link between death and MDR C. striatum (PFGE types I and II) infection was observed in five cases.

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epidemic curve for Corynebacterium striatum over time.
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f01: epidemic curve for Corynebacterium striatum over time.

Mentions: Fig. 1 presents the epidemic curve of the infections caused by C. striatum, suggestive of a nosocomial outbreak. Most of the C. striatum strains (n = 6) were isolated in December 2009 from patients from various hospital wards. The pathogen was found circulating mostly among inpatients admitted to the ICU and surgical wards (n = 10) from August 2009-April 2010 (Table). C. striatum infections were observed in the general ICU (n = 4), cardiac ICU (n = 1), ICU II (n = 2), thoracic surgery (n = 3), nursery 18 (n = 2), infectious diseases (n = 2) and urology (n = 1) wards.


Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil.

Baio PV, Mota HF, Freitas AD, Gomes DL, Ramos JN, Sant'Anna LO, Souza MC, Camello TC, Hirata Junior R, Vieira VV, Mattos-Guaraldi AL - Mem. Inst. Oswaldo Cruz (2013)

epidemic curve for Corynebacterium striatum over time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3974316&req=5

f01: epidemic curve for Corynebacterium striatum over time.
Mentions: Fig. 1 presents the epidemic curve of the infections caused by C. striatum, suggestive of a nosocomial outbreak. Most of the C. striatum strains (n = 6) were isolated in December 2009 from patients from various hospital wards. The pathogen was found circulating mostly among inpatients admitted to the ICU and surgical wards (n = 10) from August 2009-April 2010 (Table). C. striatum infections were observed in the general ICU (n = 4), cardiac ICU (n = 1), ICU II (n = 2), thoracic surgery (n = 3), nursery 18 (n = 2), infectious diseases (n = 2) and urology (n = 1) wards.

Bottom Line: C. striatum identification was confirmed by 16S rRNA and rpoB gene sequencing.Fifteen C. striatum strains were isolated from adults (half of whom were 50 years of age and older).C. striatum was mostly isolated in pure culture from tracheal aspirates of patients undergoing endotracheal intubation procedures.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Difteria e Corinebactérias de Importância Clínica, Departamento de Microbiologia, Imunologia e Patologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

ABSTRACT
Corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. Here, we document a nosocomial outbreak caused by multidrug-resistant (MDR) C. striatum in Rio de Janeiro, Brazil. C. striatum identification was confirmed by 16S rRNA and rpoB gene sequencing. Fifteen C. striatum strains were isolated from adults (half of whom were 50 years of age and older). C. striatum was mostly isolated in pure culture from tracheal aspirates of patients undergoing endotracheal intubation procedures. The analysis by pulsed-field gel electrophoresis (PFGE) indicated the presence of four PFGE profiles, including two related clones of MDR strains (PFGE I and II). The data demonstrated the predominance of PFGE type I, comprising 11 MDR isolates that were mostly isolated from intensive care units and surgical wards. A potential causal link between death and MDR C. striatum (PFGE types I and II) infection was observed in five cases.

Show MeSH
Related in: MedlinePlus