Limits...
Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical centre, Mwanza, Tanzania.

Mashuda F, Zuechner A, Chalya PL, Kidenya BR, Manyama M - BMC Res Notes (2014)

Bottom Line: Echocardiography, X-ray, cranial as well as abdominal ultrasonographies were performed when indicated.In this study, the proportion of women taking folic acid supplements during early pregnancy was very low.Efforts should be made to ensure that more women use folic acid during the peri-conceptional period, as the use of folic acid supplement has been linked by several authors to a reduced occurrence of some congenital anomalies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Anatomy and Cell Biology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania. manyama73@yahoo.com.

ABSTRACT

Background: Congenital anomalies or birth defects are among the leading causes of infant mortality and morbidity around the world. The impact of congenital anomalies is particularly severe in middle- and low-income countries where health care resources are limited. The prevalence of congenital anomalies varies in different parts of the world, which could reflect different aetiological factors in different geographical regions.

Methods: Between October 2012 and January 2013, a cross-sectional study was conducted involving young infants below 2 months of age, admitted at a university teaching hospital in Tanzania. Face-to-face interviews with parents/caretakers of young infants were carried out to collect socio-demographic and clinical information. Physical examinations were performed on all young infants. Echocardiography, X-ray, cranial as well as abdominal ultrasonographies were performed when indicated.

Results: Analysis of the data showed that among 445 young infants enrolled in the study, the prevalence of congenital anomalies was 29%, with the Central Nervous System (CNS) as the most commonly affected organ system. Maternal factors that were significantly associated with congenital anomalies included the lack of peri-conceptional use of folic acid (OR = 3.1; 95% CI = 1.4-6.7; p = 0.005), a maternal age of above 35 years (OR = 2.2; 95% CI = 1.1-4.3; p = 0.024) and an inadequate attendance to antenatal clinic (OR = 2.1; 95% CI = 1.4-3.3; p < 0.001). Infant factors that were significantly associated with congenital anomalies were female sex, a birth weight of 2.5 kg or more, singleton pregnancy and a birth order above 4.

Conclusions: Due to the high prevalence of congenital anomalies observed in this particular context, the hospital should mobilize additional resources for an optimal and timely management of the patients with congenital anomalies. In this study, the proportion of women taking folic acid supplements during early pregnancy was very low. Efforts should be made to ensure that more women use folic acid during the peri-conceptional period, as the use of folic acid supplement has been linked by several authors to a reduced occurrence of some congenital anomalies.

Show MeSH

Related in: MedlinePlus

Distribution of congenital anomalies according to ICD 10 among young infants admitted at Bugando Medical Centre from October 2012 to Jan 2013. Key: CNS: central nervous system, MSS: musculoskeletal system, GIT: gastrointestinal tract, MCA: multiple congenital anomalies involving at least 3 systems, CVS: cardiovascular system, US: urinary system, GS: genital system. Others: CNS + GIT, CVS + GIT, GIT + GS, GIT + MSS, MSS + CVS, Pierre Robbin’s syndrome, Skin, Skin + MSS.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC3974194&req=5

Figure 1: Distribution of congenital anomalies according to ICD 10 among young infants admitted at Bugando Medical Centre from October 2012 to Jan 2013. Key: CNS: central nervous system, MSS: musculoskeletal system, GIT: gastrointestinal tract, MCA: multiple congenital anomalies involving at least 3 systems, CVS: cardiovascular system, US: urinary system, GS: genital system. Others: CNS + GIT, CVS + GIT, GIT + GS, GIT + MSS, MSS + CVS, Pierre Robbin’s syndrome, Skin, Skin + MSS.

Mentions: During the study period, 131 infants among the 445 examined were found with congenital anomalies. This gives a prevalence rate of 29%. The most affected body system was the central nervous system which accounted for 39 of the cases (29.8%), followed by the musculoskeletal and gastrointestinal systems for 30 (22.9%) and 12 (9.2%) cases respectively (Figure 1). Among the infants with CNS malformations, spina bifida was the most common, followed closely by hydrocephalus, with 16 (38.5%) and 14 (35.9%) cases respectively (Table 1). Other CNS congenital anomalies are shown in Table 1.


Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical centre, Mwanza, Tanzania.

Mashuda F, Zuechner A, Chalya PL, Kidenya BR, Manyama M - BMC Res Notes (2014)

Distribution of congenital anomalies according to ICD 10 among young infants admitted at Bugando Medical Centre from October 2012 to Jan 2013. Key: CNS: central nervous system, MSS: musculoskeletal system, GIT: gastrointestinal tract, MCA: multiple congenital anomalies involving at least 3 systems, CVS: cardiovascular system, US: urinary system, GS: genital system. Others: CNS + GIT, CVS + GIT, GIT + GS, GIT + MSS, MSS + CVS, Pierre Robbin’s syndrome, Skin, Skin + MSS.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3974194&req=5

Figure 1: Distribution of congenital anomalies according to ICD 10 among young infants admitted at Bugando Medical Centre from October 2012 to Jan 2013. Key: CNS: central nervous system, MSS: musculoskeletal system, GIT: gastrointestinal tract, MCA: multiple congenital anomalies involving at least 3 systems, CVS: cardiovascular system, US: urinary system, GS: genital system. Others: CNS + GIT, CVS + GIT, GIT + GS, GIT + MSS, MSS + CVS, Pierre Robbin’s syndrome, Skin, Skin + MSS.
Mentions: During the study period, 131 infants among the 445 examined were found with congenital anomalies. This gives a prevalence rate of 29%. The most affected body system was the central nervous system which accounted for 39 of the cases (29.8%), followed by the musculoskeletal and gastrointestinal systems for 30 (22.9%) and 12 (9.2%) cases respectively (Figure 1). Among the infants with CNS malformations, spina bifida was the most common, followed closely by hydrocephalus, with 16 (38.5%) and 14 (35.9%) cases respectively (Table 1). Other CNS congenital anomalies are shown in Table 1.

Bottom Line: Echocardiography, X-ray, cranial as well as abdominal ultrasonographies were performed when indicated.In this study, the proportion of women taking folic acid supplements during early pregnancy was very low.Efforts should be made to ensure that more women use folic acid during the peri-conceptional period, as the use of folic acid supplement has been linked by several authors to a reduced occurrence of some congenital anomalies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Anatomy and Cell Biology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania. manyama73@yahoo.com.

ABSTRACT

Background: Congenital anomalies or birth defects are among the leading causes of infant mortality and morbidity around the world. The impact of congenital anomalies is particularly severe in middle- and low-income countries where health care resources are limited. The prevalence of congenital anomalies varies in different parts of the world, which could reflect different aetiological factors in different geographical regions.

Methods: Between October 2012 and January 2013, a cross-sectional study was conducted involving young infants below 2 months of age, admitted at a university teaching hospital in Tanzania. Face-to-face interviews with parents/caretakers of young infants were carried out to collect socio-demographic and clinical information. Physical examinations were performed on all young infants. Echocardiography, X-ray, cranial as well as abdominal ultrasonographies were performed when indicated.

Results: Analysis of the data showed that among 445 young infants enrolled in the study, the prevalence of congenital anomalies was 29%, with the Central Nervous System (CNS) as the most commonly affected organ system. Maternal factors that were significantly associated with congenital anomalies included the lack of peri-conceptional use of folic acid (OR = 3.1; 95% CI = 1.4-6.7; p = 0.005), a maternal age of above 35 years (OR = 2.2; 95% CI = 1.1-4.3; p = 0.024) and an inadequate attendance to antenatal clinic (OR = 2.1; 95% CI = 1.4-3.3; p < 0.001). Infant factors that were significantly associated with congenital anomalies were female sex, a birth weight of 2.5 kg or more, singleton pregnancy and a birth order above 4.

Conclusions: Due to the high prevalence of congenital anomalies observed in this particular context, the hospital should mobilize additional resources for an optimal and timely management of the patients with congenital anomalies. In this study, the proportion of women taking folic acid supplements during early pregnancy was very low. Efforts should be made to ensure that more women use folic acid during the peri-conceptional period, as the use of folic acid supplement has been linked by several authors to a reduced occurrence of some congenital anomalies.

Show MeSH
Related in: MedlinePlus