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Age-related bone turnover markers and osteoporotic risk in native Chinese women.

Wu XY, Li HL, Xie H, Luo XH, Peng YQ, Yuan LQ, Sheng ZF, Dai RC, Wu XP, Liao EY - BMC Endocr Disord (2014)

Bottom Line: Pearson's correlation coefficient found significant negative correlation between bone turnover marker and BMD T-score at different skeletal sites (r = -0.08 to -0.52, all P = 0.038-0.000).Bone turnover marker levels were found to be important determinants of BMD T-scores.Furthermore, osteoporotic risk significantly increased with increase in the levels of bone turnover markers.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, No,139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China. wuxp39@sohu.com.

ABSTRACT

Background: The rate of bone turnover is closely related to osteoporosis risk. We investigated the correlation between bone turnover markers and BMD at various skeletal sites in healthy native Chinese women, and to study the effect of changes in the levels of bone turnover markers on the risk of osteoporosis.

Methods: A cross-section study of 891 healthy Chinese women aged 20-80 years was conducted. The levels of serum osteocalcin (OC), bone-specific alkaline phosphatase (BAP), serum cross-linked N-terminal telopeptides of type I collagen (sNTX), cross-linked C-terminal telopeptides of type I collagen (sCTX), urinary NTX (uNTX), urinary CTX (uCTX) and total urinary deoxypyridinoline (uDPD) were determined. BMD at the posteroanterior spine and the hip was measured using DXA.

Results: Pearson's correlation coefficient found significant negative correlation between bone turnover marker and BMD T-score at different skeletal sites (r = -0.08 to -0.52, all P = 0.038-0.000). After adjustments for age and body mass index, the partial correlation coefficients between the OC, BAP, sNTX, sCTX and uCTX, and the T-scores at various skeletal sites were still significant. After adjustment of height and weight, the correlation coefficients between most BTMs and PA lumbar spine BMD were also significant. Multiple linear regression analysis showed that bone turnover markers were negative determinants of T-scores. BAP and OC accounted for 33.1% and 7.8% of the variations in the T-scores of the PA spine, respectively. Serum OC, BAP, uDPD, and sNTX accounted for 0.4-21.9% of the variations in the femoral neck and total hip T-scores. The bone turnover marker levels were grouped as per quartile intervals, and the T-scores, osteoporosis prevalence and risk were found to markedly and increase with increase in bone turnover marker levels.

Conclusions: This study clarified the relationship between bone turnover markers and osteoporosis risk in native Chinese women. Bone turnover marker levels were found to be important determinants of BMD T-scores. Furthermore, osteoporotic risk significantly increased with increase in the levels of bone turnover markers.

No MeSH data available.


Related in: MedlinePlus

BMD T-scores (mean and SE) at different skeletal sites for native Chinese women, by quartiles of bone turnover markers. Abbreviations: BAP-bone-specific alkaline phosphatase, OC-osteocalcin, sCTX-serum cross-linked C-terminal telopeptides of type I collagen (CTX), sNTX-serum cross-linked N-terminal telopeptides of type I collagen, uCTX-urinary CTX, uNTX-urinary NTX, uDPD-urinary deoxypyridinoline, PA-posteroanterior spine, FN-femoral neck, Q1-first quartile, Q2-second quartile, Q3-third quartile, Q4-fourth quartile. *P = 0.045–0.000 compared with Q2, Q3 and Q4. ▲P = 0.029–0.000 compared with Q3 and Q4. #P = 0.013–0.000 compared with Q4.
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Figure 1: BMD T-scores (mean and SE) at different skeletal sites for native Chinese women, by quartiles of bone turnover markers. Abbreviations: BAP-bone-specific alkaline phosphatase, OC-osteocalcin, sCTX-serum cross-linked C-terminal telopeptides of type I collagen (CTX), sNTX-serum cross-linked N-terminal telopeptides of type I collagen, uCTX-urinary CTX, uNTX-urinary NTX, uDPD-urinary deoxypyridinoline, PA-posteroanterior spine, FN-femoral neck, Q1-first quartile, Q2-second quartile, Q3-third quartile, Q4-fourth quartile. *P = 0.045–0.000 compared with Q2, Q3 and Q4. ▲P = 0.029–0.000 compared with Q3 and Q4. #P = 0.013–0.000 compared with Q4.

Mentions: Figure 1 shows the grouping of the levels of bone turnover markers according to quartile intervals, and a comparison of the BMD T-scores in the different study groups. A marked, progressive decrease of T-scores at various skeletal sites was observed with increase in bone turnover marker levels. Apart from sNTX, sCTX and uDPD, the remaining bone turnover markers were associated with an decreasing tendency of T-scores at various skeletal sites in the order of Q1 > Q2 > Q3 > Q4. By using bone turnover markers as independent variables and T-scores as dependent variables, we performed a multiple linear regression stepwise analysis (Table 3). The results showed that serum BAP and OC were significant negative determinants of the T-score of the PA spine, and accounted for approximately 33.1% and 7.8% of the changes in T-scores of the PA spine. Serum OC, BAP and sNTX were significant negative determinants of T-scores at femoral neck and total hip.


Age-related bone turnover markers and osteoporotic risk in native Chinese women.

Wu XY, Li HL, Xie H, Luo XH, Peng YQ, Yuan LQ, Sheng ZF, Dai RC, Wu XP, Liao EY - BMC Endocr Disord (2014)

BMD T-scores (mean and SE) at different skeletal sites for native Chinese women, by quartiles of bone turnover markers. Abbreviations: BAP-bone-specific alkaline phosphatase, OC-osteocalcin, sCTX-serum cross-linked C-terminal telopeptides of type I collagen (CTX), sNTX-serum cross-linked N-terminal telopeptides of type I collagen, uCTX-urinary CTX, uNTX-urinary NTX, uDPD-urinary deoxypyridinoline, PA-posteroanterior spine, FN-femoral neck, Q1-first quartile, Q2-second quartile, Q3-third quartile, Q4-fourth quartile. *P = 0.045–0.000 compared with Q2, Q3 and Q4. ▲P = 0.029–0.000 compared with Q3 and Q4. #P = 0.013–0.000 compared with Q4.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3974151&req=5

Figure 1: BMD T-scores (mean and SE) at different skeletal sites for native Chinese women, by quartiles of bone turnover markers. Abbreviations: BAP-bone-specific alkaline phosphatase, OC-osteocalcin, sCTX-serum cross-linked C-terminal telopeptides of type I collagen (CTX), sNTX-serum cross-linked N-terminal telopeptides of type I collagen, uCTX-urinary CTX, uNTX-urinary NTX, uDPD-urinary deoxypyridinoline, PA-posteroanterior spine, FN-femoral neck, Q1-first quartile, Q2-second quartile, Q3-third quartile, Q4-fourth quartile. *P = 0.045–0.000 compared with Q2, Q3 and Q4. ▲P = 0.029–0.000 compared with Q3 and Q4. #P = 0.013–0.000 compared with Q4.
Mentions: Figure 1 shows the grouping of the levels of bone turnover markers according to quartile intervals, and a comparison of the BMD T-scores in the different study groups. A marked, progressive decrease of T-scores at various skeletal sites was observed with increase in bone turnover marker levels. Apart from sNTX, sCTX and uDPD, the remaining bone turnover markers were associated with an decreasing tendency of T-scores at various skeletal sites in the order of Q1 > Q2 > Q3 > Q4. By using bone turnover markers as independent variables and T-scores as dependent variables, we performed a multiple linear regression stepwise analysis (Table 3). The results showed that serum BAP and OC were significant negative determinants of the T-score of the PA spine, and accounted for approximately 33.1% and 7.8% of the changes in T-scores of the PA spine. Serum OC, BAP and sNTX were significant negative determinants of T-scores at femoral neck and total hip.

Bottom Line: Pearson's correlation coefficient found significant negative correlation between bone turnover marker and BMD T-score at different skeletal sites (r = -0.08 to -0.52, all P = 0.038-0.000).Bone turnover marker levels were found to be important determinants of BMD T-scores.Furthermore, osteoporotic risk significantly increased with increase in the levels of bone turnover markers.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, No,139 Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China. wuxp39@sohu.com.

ABSTRACT

Background: The rate of bone turnover is closely related to osteoporosis risk. We investigated the correlation between bone turnover markers and BMD at various skeletal sites in healthy native Chinese women, and to study the effect of changes in the levels of bone turnover markers on the risk of osteoporosis.

Methods: A cross-section study of 891 healthy Chinese women aged 20-80 years was conducted. The levels of serum osteocalcin (OC), bone-specific alkaline phosphatase (BAP), serum cross-linked N-terminal telopeptides of type I collagen (sNTX), cross-linked C-terminal telopeptides of type I collagen (sCTX), urinary NTX (uNTX), urinary CTX (uCTX) and total urinary deoxypyridinoline (uDPD) were determined. BMD at the posteroanterior spine and the hip was measured using DXA.

Results: Pearson's correlation coefficient found significant negative correlation between bone turnover marker and BMD T-score at different skeletal sites (r = -0.08 to -0.52, all P = 0.038-0.000). After adjustments for age and body mass index, the partial correlation coefficients between the OC, BAP, sNTX, sCTX and uCTX, and the T-scores at various skeletal sites were still significant. After adjustment of height and weight, the correlation coefficients between most BTMs and PA lumbar spine BMD were also significant. Multiple linear regression analysis showed that bone turnover markers were negative determinants of T-scores. BAP and OC accounted for 33.1% and 7.8% of the variations in the T-scores of the PA spine, respectively. Serum OC, BAP, uDPD, and sNTX accounted for 0.4-21.9% of the variations in the femoral neck and total hip T-scores. The bone turnover marker levels were grouped as per quartile intervals, and the T-scores, osteoporosis prevalence and risk were found to markedly and increase with increase in bone turnover marker levels.

Conclusions: This study clarified the relationship between bone turnover markers and osteoporosis risk in native Chinese women. Bone turnover marker levels were found to be important determinants of BMD T-scores. Furthermore, osteoporotic risk significantly increased with increase in the levels of bone turnover markers.

No MeSH data available.


Related in: MedlinePlus